LOCUS AY248754 19810 bp DNA linear PRI 12-MAR-2003 DEFINITION Homo sapiens tumor necrosis factor, alpha-induced protein 3 (TNFAIP3) gene, complete cds. ACCESSION AY248754 VERSION AY248754.1 GI:28932977 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 19810) AUTHORS Rieder,M.J., Carrington,D.P., da Ponte,S.H., Hastings,N.C., Ahearn,M.O., Kuldanek,S.A., Rajkumar,N., Toth,E.J., Yi,Q. and Nickerson,D.A. TITLE Direct Submission JOURNAL Submitted (04-MAR-2003) Genome Sciences, University of Washington, 1705 NE Pacific, Seattle, WA 98195, USA COMMENT To cite this work please use: SeattleSNPs. NHLBI HL66682 Program for Genomic Applications, UW-FHCRC, Seattle, WA (URL: http://pga.gs.washington.edu). FEATURES Location/Qualifiers source 1..19810 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" variation 104 /frequency="0.01" /replace="g" repeat_region 146..240 /rpt_family="MIR" /rpt_type=dispersed variation 548 /frequency="0.02" /replace="t" variation 868 /frequency="0.16" /replace="t" variation 1099 /frequency="0.01" /replace="a" variation 1610 /frequency="0.02" /replace="a" misc_feature 1747..1980 /note="Region not scanned for variation" gene 1951..17831 /gene="TNFAIP3" mRNA join(1951..2001,5721..6030,9353..9543,10197..10344, 10505..10675,11585..11765,12941..13860,14580..14761, 15540..17831) /gene="TNFAIP3" /product="tumor necrosis factor, alpha-induced protein 3" variation 2523 /gene="TNFAIP3" /frequency="0.95" /replace="" variation 2886 /gene="TNFAIP3" /frequency="0.21" /replace="g" variation 3101 /gene="TNFAIP3" /frequency="0.02" /replace="g" variation 3233 /gene="TNFAIP3" /frequency="0.01" /replace="g" variation 3255 /gene="TNFAIP3" /frequency="0.39" /replace="c" variation 3313 /gene="TNFAIP3" /frequency="0.28" /replace="t" variation 3492..3493 /gene="TNFAIP3" /frequency="0.33" /replace="" variation 3525 /gene="TNFAIP3" /frequency="0.28" /replace="g" repeat_region 3609..3721 /rpt_family="MIR" /rpt_type=dispersed variation 4008 /gene="TNFAIP3" /frequency="0.01" /replace="t" variation 4055 /gene="TNFAIP3" /frequency="0.22" /replace="c" variation 4187 /gene="TNFAIP3" /frequency="0.07" /replace="g" repeat_region 4800..4929 /rpt_family="Alu" /rpt_type=dispersed variation 5014 /gene="TNFAIP3" /frequency="0.01" /replace="t" variation 5433 /gene="TNFAIP3" /frequency="0.09" /replace="g" CDS join(5736..6030,9353..9543,10197..10344,10505..10675, 11585..11765,12941..13860,14580..14761,15540..15824) /gene="TNFAIP3" /codon_start=1 /product="tumor necrosis factor, alpha-induced protein 3" /protein_id="AAO61093.1" /db_xref="GI:28932978" /translation="MAEQVLPQALYLSNMRKAVKIRERTPEDIFKPTNGIIHHFKTMH RYTLEMFRTCQFCPQFREIIHKALIDRNIQATLESQKKLNWCREVRKLVALKTNGDGN CLMHATSQYMWGVQDTDLVLRKALFSTLKETDTRNFKFRWQLESLKSQEFVETGLCYD TRNWNDEWDNLIKMASTDTPMARSGLQYNSLEEIHIFVLCNILRRPIIVISDKMLRSL ESGSNFAPLKVGGIYLPLHWPAQECYRYPIVLGYDSHHFVPLVTLKDSGPEIRAVPLV NRDRGRFEDLKVHFLTDPENEMKEKLLKEYLMVIEIPVQGWDHGTTHLINAAKLDEAN LPKEINLVDDYFELVQHEYKKWQENSEQGRREGHAQNPMEPSVPQLSLMDVKCETPNC PFFMSVNTQPLCHECSERRQKNQNKLPKLNSKPGPEGLPGMALGASRGEAYEPLAWNP EESTGGPHSAPPTAPSPFLFSETTAMKCRSPGCPFTLNVQHNGFCERCHNARQLHASH APDHTRHLDPGKCQACLQDVTRTFNGICSTCFKRTTAEASSSLSTSLPPSCHQRSKSD PSRLVRSPSPHSCHRAGNDAPAGCLSQAARTPGDRTGTSKCRKAGCVYFGTPENKGFC TLCFIEYRENKHFAAASGKVSPTASRFQNTIPCLGRECGTLGSTMFEGYCQKCFIEAQ NQRFHEAKRTEEQLRSSQRRDVPRTTQSTSRPKCARASCKNILACRSEELCMECQHPN QRMGPGAHRGEPAPEDPPKQRCRAPACDHFGNAKCNGYCNECFQFKQMYG" variation 6116 /gene="TNFAIP3" /frequency="0.29" /replace="a" variation 6132 /gene="TNFAIP3" /frequency="0.29" /replace="g" variation 6880 /gene="TNFAIP3" /frequency="0.01" /replace="t" variation 8114 /gene="TNFAIP3" /frequency="0.01" /replace="g" variation 8143 /gene="TNFAIP3" /frequency="0.01" /replace="g" variation 8308 /gene="TNFAIP3" /frequency="0.09" /replace="a" variation 8412 /gene="TNFAIP3" /frequency="0.34" /replace="g" variation 8522 /gene="TNFAIP3" /frequency="0.18" /replace="t" variation 8773 /gene="TNFAIP3" /frequency="0.39" /replace="t" repeat_region 8966..9136 /rpt_family="MIR" /rpt_type=dispersed variation 9004 /gene="TNFAIP3" /frequency="0.08" /replace="t" variation 9064 /gene="TNFAIP3" /frequency="0.38" /replace="t" variation 9094 /gene="TNFAIP3" /frequency="0.18" /replace="g" variation 9335..9337 /gene="TNFAIP3" /frequency="0.32" /replace="" variation 9431 /gene="TNFAIP3" /frequency="0.02" /replace="t" variation 9437 /gene="TNFAIP3" /frequency="0.20" /replace="g" variation 9959 /gene="TNFAIP3" /frequency="0.91" /replace="" variation 9972 /gene="TNFAIP3" /frequency="0.01" /replace="a" variation 9980 /gene="TNFAIP3" /frequency="0.02" /replace="a" variation 10034 /gene="TNFAIP3" /frequency="0.01" /replace="a" variation 10189 /gene="TNFAIP3" /frequency="0.02" /replace="g" variation 10701 /gene="TNFAIP3" /frequency="0.11" /replace="t" variation 10703 /gene="TNFAIP3" /frequency="0.32" /replace="c" variation 10713 /gene="TNFAIP3" /frequency="0.01" /replace="g" variation 10878 /gene="TNFAIP3" /frequency="0.12" /replace="g" repeat_region 10960..11109 /rpt_family="Alu" /rpt_type=dispersed repeat_region 11145..11356 /rpt_family="MIR" /rpt_type=dispersed variation 11152 /gene="TNFAIP3" /frequency="0.01" /replace="a" variation 11196 /gene="TNFAIP3" /frequency="0.36" /replace="c" variation 12354 /gene="TNFAIP3" /frequency="0.01" /replace="t" variation 12428 /gene="TNFAIP3" /frequency="0.11" /replace="" variation 12480 /gene="TNFAIP3" /frequency="0.01" /replace="g" variation 12789 /gene="TNFAIP3" /frequency="0.43" /replace="t" variation 14132 /gene="TNFAIP3" /frequency="0.04" /replace="a" variation 14224 /gene="TNFAIP3" /frequency="0.02" /replace="a" variation 14939 /gene="TNFAIP3" /frequency="0.01" /replace="a" variation 15208 /gene="TNFAIP3" /frequency="0.01" /replace="a" variation 15746 /gene="TNFAIP3" /frequency="0.01" /replace="t" variation 15747 /gene="TNFAIP3" /frequency="0.01" /replace="c" variation 16657 /gene="TNFAIP3" /frequency="0.01" /replace="t" variation 16904 /gene="TNFAIP3" /frequency="0.01" /replace="g" variation 17031 /gene="TNFAIP3" /frequency="0.01" /replace="t" variation 17677 /gene="TNFAIP3" /frequency="0.03" /replace="c" variation 18009 /frequency="0.03" /replace="" repeat_region 18329..18425 /rpt_family="MER1_type" /rpt_type=dispersed repeat_region 18436..18768 /rpt_family="L1" /rpt_type=dispersed repeat_region 18827..18898 /rpt_family="L1" /rpt_type=dispersed repeat_region 18907..19103 /rpt_family="L1" /rpt_type=dispersed repeat_region 19107..19174 /rpt_family="Alu" /rpt_type=dispersed repeat_region 19223..19809 /rpt_family="L1" /rpt_type=dispersed variation 19256 /frequency="0.02" /replace="t" variation 19384 /frequency="0.09" /replace="a" misc_feature 19657..19810 /note="Region not scanned for variation" ORIGIN 1 aaaccaagac ccttctacct ctgaagccgc attctgtcta aggtccgtgt ttggctgttt 61 tgagaggctg ggagacagga caccaaaaga gtacctgtct cacaggatct ttcctgagag 121 gaatggtcta gtaagactgg tcattatggg ctttggagta acacaggctt aatgccactg 181 gcgactctgc cccttttggt tgtggaaact gggcaaatgc ctcaagcttc ttaaccttca 241 tataaaaagc atatataagc atatagcaag tacttgataa atgtcatttt agaccctgtc 301 atttctgcta gccctggact ccagcaaggt ccatttacaa tggatagctg actatccatt 361 gtttgaatgt tgatagcaca tttgtgaaca agaagagagg acaaataaca agaggtttgg 421 aactggaaga aattccagcc atcggtttta aaagacgagg accagtcttc agagaggcca 481 ctagtgacac tctgctccaa acttcttttt gccaaaaaag tgccaccctc catccagccc 541 ccacccccat ctctgcaagt ccttactggc gagaggagga tacttttcta attaaaaacc 601 tgtgatatat ggcctgacaa gtattcttaa atgtaattaa ggggaccata gtacagaata 661 tttccatccg gttctagttt agccaatcta gtaaatgatc caaagggtcc cgtgcttaga 721 gggcagtaag acagtaaaaa cgccctaaga ctcctccctg cacagcacct gcacccccac 781 tgcccagggg gctgcatcca tctccacatg actcaccctc cctgtgcaac gcatgggggt 841 agggagggaa gcgccagtat tatcagccat cagcaccctg gggtgaactg attatcagga 901 caactaaaaa cacacctaat aaagccttgg agacacatgg caagcaccgt gatggactag 961 aagcgatttc taagctgaaa tgctgctttg aatgcaatgt cagctggatg cttggtgagc 1021 agaaatagac aaggggaaat ggagcaagcg cggcataggg gtgagtgttg ttctgattcc 1081 taagtttacc taagactggg gccacggggt cgggtgtccc ctgggaccta cgtctcatgc 1141 agcctggggt ccagagctgg caggaacaat ggagatgggg accaaaggct gtcaccgctg 1201 ctttttctcg aaatgcccgc ccgggtcctg tctggggctc ccgcctacgc gctcatcacg 1261 tgcacagccc aaacttttca gagccggccc gaggcctgcg ggcccgggcg ccagggtggt 1321 ttttagggtt ttctttcttt cttatttccc ttcttcttct ccacagttga tgattttctg 1381 cagaaaaaca actgcgaaaa agaacctatt tcatttccag ttcccatcac cgcgatttcc 1441 acatggatgt gacgtgaccc cagcttccga aatgcccagg tgactcacgc ggggacaccc 1501 cggggcgggg cgagggagtt tctccgggcg cctgcaggga ccgggcgggg cggggcagcg 1561 gggcggggca gggaaagggg gcggggcggg gcccgcaggc ccggtcgggc ggaggccgcg 1621 cgcgcccctc gccccctgcg ccctctggcg gccggctgga cgcacttcgc agcccgaccc 1681 agagagtcac gtgactttgg aaagtcccgt ggaaatcccc gggcctacaa cccgcataca 1741 actgaaacgg ggcaaagcag actgcgcagt ctgcagtctt cgtggcgggc caagcgagct 1801 tggagcccgc gggggcggag cggtgagagc ggccgccaag agagatcaca cccccagccg 1861 accctgccag cgagcgagcc cgaccccagg cgtccatgga gcgtcgcctc cgcccggtcc 1921 ctgccccgac ccccgcctgc ggcgcgctcc tgccttgacc aggacttggg actttgcgaa 1981 aggatcgcgg ggcccggaga ggtaaccgcc gcgcctcccg gagaggtaac cgccgcgcct 2041 cccggagagg taaccgccgc gcctccccgt gccgtctgcc tcgggctcac cgcagtcaag 2101 ggctgcgggt gcatgttggg cagcgacccc cgggctggca ccgtctacct ggcgttggtt 2161 ttgcagcgct cctggactgg gagtttgttg gacgtttctg tctgggtttt gaagtgctgg 2221 gagttgaggt cactgctgca gaggttggag tgacagccct ggatacctcc agccagctgt 2281 tcctttcaga taatgcacgg aacttaagct gcagctgact ggtgaagagg cgcccctcgg 2341 gccctccgat cgggtggtcg ttggcgcttt gctcctttcg tgtctttttt ggagccaagc 2401 gttgcatgct catggccacg tagaccttgc agaagcgctg cggctttttc ccaaattgtg 2461 caggaccagc ccgacggggc gtagggtacc gcagtggccg ccagcccggc ggaggtgggg 2521 gggcttcagt cccagagaca gcttcccaga cgctcacggg tccttgcagg gggctggggt 2581 cctggcgcgg ggttcagctt ttccagtagc agcagtgtaa gagaagtatg catgtagacg 2641 tgggtcgctg gcccctgctc cagcccctac cccacggtta gactgtcttt gtcagctgga 2701 gtcgtcccac atcctgccac ctggcctctc agaaaagcag tggcattaag taaggaagga 2761 gcttaactct ttttgagccc gctttgtttt cggttctcct cgcctcagat cttcttgcct 2821 tggaaagcca gtctggtcaa gtgtctcagg gtagcatttt ggcagaacca ttgttaatta 2881 aagggacttc tggaccgcaa ccttaatgta ccagattatt gagcagccaa tgaatgcttc 2941 attctcattg tttaaggtgc tgctttgatt tttttttcaa ttctttgtac tatttttgat 3001 tttttggaga ggcacatccc caaatttgga tgaggtattt gttgataaat aattcatcaa 3061 tttccacaat gcagacaaaa atgtctgccc agagtggaaa aataaaacaa gggggagaag 3121 agtttgagta acggagaagt tctgtggaat cctagtgaca aaagttgaga aactaccttt 3181 aaataagaca gtgaggtaac aaatgttaaa aaaaaaaaag ttaagggtaa tattgcattg 3241 tttgccactt ataatgtatc tgaaacattt gttctttaat cttaagcgta gagtggtcca 3301 agacctggaa atctgggcag tgggttttga tttctaagga ggcagtttta caggctgtgc 3361 aaggctaacc ctaccaatga gatcacactg gcgtatccga tattgacatt tgcatgtctt 3421 gcctatggtt tacagctctc actattttag atctttggtg aaaaatcttt agattcagaa 3481 gagaaaaata aaagagtcag gcaagcaaaa agagataaca cctcatttgt ttaaaatctt 3541 cctactgccc atctctttcc atctgattgt ggcaggcact gtagccacag gtttggtgtt 3601 gtgggattgc aaggggcagg tattgaaaga cctggctcct aggcaaaact ttgcccctga 3661 atggctgtgg gatctgagca gtacctgtaa ctccattgcc ttagctgcag actaaggtgg 3721 tagtgtaatt tcagggaagg gaataaggtc atctttgact tttagtccca tcatcaagca 3781 tggtgattgg ccttcagtag gtggtcaggt agtgcttgtt gggtggatgg gtggatggat 3841 ggatagatgg atggatggat ggatggatgg atggatggat ggatggacgg acggacggac 3901 ggacggatag atgatattgt gaaagagact tttgctgtgc cacaaaggaa aggtatatgt 3961 gttattttta tcctgctatg attttgccca attccacctg tagaggacgt ctgacatcaa 4021 aagagagcac catctgatcc agagaatgac tcccactatg cctttcccag caatcagatt 4081 aagaatccca atctaaaact atcaccagaa aactcctcag gagaaaccat gggtcatcta 4141 gtccaacctc tctcctttga gtgggccaca agaattatct caacacctta tcaatggtgt 4201 tgagagtcta gacccacaca gaagtagcta ccctaaaatc taggtttctt ctcctccctc 4261 ttccataggt ttaacatttt tattaactgg aaagttgccc tggcaaataa gatgttgcag 4321 gaatggaatt aacaatcact gtgaaatttc ctagggaatg tctttgtgct ctgaaaactt 4381 cttcatcttc ttggaaatta ggaagtgtgg ccagacaccc tactaagggc tagtaaatca 4441 cagctggctt tttacagtgt tccacactgg agagatccta catcatgtta atttgcatca 4501 tcctgcgctg ttggcatggg ttgtagatgc tggtctttgc cacctttcct ccttcatttg 4561 ccagagtggc ctcctggtgg aaacttcttt ccttgtctac ttctagattt tcattccttc 4621 tactagttga ttatgcttaa agatttcagg gtgaaaagcc aggcagactt gcctctgtgt 4681 tggtacctgg agggtgatga taaaatttca ttggcagttg agttaaaatg attgagctcc 4741 aatatctgtt cttagaagta tagaatttat tgttctatta ttattttgcg gtttttcatt 4801 ttttgttttc gtagagacct aggtctcacc gtgttgccca ggctagtctc aaactcctga 4861 gcttaagtga tcctcctccc tcgacctccc aaagtgccag gattaaaggc atgagccacc 4921 atgcctagcc tattgttagt ctgtttctta ttctgatatg aagtccggtg cggaggttct 4981 gaaggaatgc tgactgctct taaaattgca aagcatcttg ctggaaatgg acttttttat 5041 tgattagaaa acattcggtt ttaactcttt ataaacatca gaataaactt catgattaaa 5101 cactttataa atacttctct ttggggctaa agaggaaaca ccaaccagca gcctaagtga 5161 cagcataaaa ttgcaagatt tttcataaag tattttactg tccttccagc atagggaggg 5221 agtgataact caagagtttg cccaagagca ggagtgcttg gtggtggtct gaggggagga 5281 gctacagact tgtcagggct actttgagcc cttaactggc atccagtact ccccaaatcc 5341 agtgctgttc agggtggcct cagaatgaaa cgggagctta agttggtttt gaggagcagt 5401 acctgttgct gacagacagg gttggctccc tgacaaacat tactgaaaac acgggttatt 5461 cccctcctcc tcagtaccca ctctctgcct tccttctctt gtttaggcta atcttttaaa 5521 gtgatgtaac ttaaaacagt ccagtgtgag ttaatctctg gggccagcta gtatcccggg 5581 agtagaggtg ctaagatctt ttgcctacag atcagggtaa tgacaagatc aaacactggg 5641 gtttcctgca ggcagctata gaggagtcgt attaaagtca ggctaataga atggcttttt 5701 ttttttcctt tccttttcag gtgttggaga gcacaatggc tgaacaagtc cttcctcagg 5761 ctttgtattt gagcaatatg cggaaagctg tgaagatacg ggagagaact ccagaagaca 5821 tttttaaacc tactaatggg atcattcatc attttaaaac catgcaccga tacacactgg 5881 aaatgttcag aacttgccag ttttgtcctc agtttcggga gatcatccac aaagccctca 5941 tcgacagaaa catccaggcc accctggaaa gccagaagaa actcaactgg tgtcgagaag 6001 tccggaagct tgtggcgctg aaaacgaacg gtaagacttg ttctgttgtg tttcttttgc 6061 ctgggtgata gctcccgcct gctggatccc cattcatgaa gctttaatag gacaagccca 6121 aactcaaatc aatcttgaga tttagtattg agacctttat atagaatctc tattcggggt 6181 atgtgataat agcagacttg ttttgtgaat ctatttatta aggatatttt ctgattgtgt 6241 atattgcaga gcacattgag gcttggagaa tgcatttgta aacaccatac ctccattagg 6301 tgatttcttt ctaattcttg caaatgtcta atcatctgta aaataccctt ctctggcccg 6361 taatggaaat gttaaaagcc tttaagttca aaaggaaaga atggtgtgaa aactggtagt 6421 acatttgttt cccactgtca ttagaaaatg cttgtgatgt tcttacactt cttgaattgg 6481 tagcatttta tgggttaacc agtgaatggc tgttgaagac atgaagaact tcttttgtct 6541 cctcctcctc tctgacctag gttctattgc ctatgccctg caaggtgaaa tagacagata 6601 gctgagattt ttagcatgaa ttttagactt caccttcatt atttttaggg gttcttagtc 6661 actgaattcc ttcctgtctg tgctgttctg ccaatggcct ttaccactag tagctatttc 6721 ctattccaag ctttactgtt ttgtttttta atcatttccc ttgggtaaga atatgtgcat 6781 caacaggaat gtcagagcat actgtttcat gcaggcacaa aattctgctc tatggatgtg 6841 cataattatg acaataagga agttgactgt acaagctcaa ttaaatgctc atagtctaca 6901 taagagcagg aatctcaggt ccttatatct gtgacagtcc caaaccatcc taatagaaat 6961 aatatgtcca agggcagaaa atccttgttg acaaggatta cgataagaac actaacttaa 7021 ttaacttcat tcaaaagcca agtacattaa ctttggcttt ttttgacttg ggtaacttag 7081 agtgattggt ggacatgggt ttttaaattt tgattctggg ggctcttgta cattacccca 7141 acgtcttgcc tagatttatg aaacactgat tcttagaaac atagatagaa agaaaactgg 7201 ggatagctac tatctgcatt gttcttggca ttaaattaag tgatacttag aggtaggtaa 7261 ttatgtgaag tcatcatcac ggggtttatg tgcctgacaa tttgtggttt taatcatctc 7321 ccatttgtta ccaaaaagag atggagtcaa ctttggggga gttggaaaca aagattctgc 7381 tgaattaaaa atgtggtaga aagaggaaca ccttattaag agaattaact gacttttagc 7441 tttatttcct taagaaagga aatgctctat ttccactaga aaaaaaaaag gaatataaat 7501 aggaaacact tattttgtaa acatgtcatt taaatcaaca aggagccaca ctacaaataa 7561 aactacaaaa gcaggtgcat tttggtaaca ttttctggga aatcattttt agactcagag 7621 tccttttgtt tcttcacttt caagaaaact ccttaagatt ctaaaaaagg aagaaaagat 7681 atttagggag ggaggaaaac aaatgacttt ttctttgatt ttaattagca ccttttaaaa 7741 aaaaattaat ccttcccctg ataggagggt tcttcaaagg caatatctgt ttggggaggg 7801 ggtgattcac aagtttgcat ttgaggatat gagactgcgg tgaatgagga agggagtagg 7861 tggcataaaa ttgaaacttc atgtgaaaaa ttccagcgtc tattggctgc agcgatttca 7921 cttgtataat gagtagccct attccagctc accctgacca cacccacttg gaaagtccag 7981 ggtgcacttc gcagtttaaa tgtctacaca ccagaacaaa aagtacaata gctgttgctc 8041 aattgctagt caaataactt agcactgggg aattccagat gttacttagg gaattttata 8101 ctggtgcatc tcaataaaga actgaaagta agcacaagaa gaaaaaaagc cttatctttg 8161 ctctagattt tgcaaagggg aaatttcaac agaacgcaat cattgctaca cgtctgccaa 8221 gacacaaggc ttgggcgatc ttttttgttc atttgtttga atacttagct agtttttcta 8281 aatgtataca ttgaaggaat actggctgtg gaagtatatt tgagggtttt ttggtttctt 8341 tacagtttga ctgtaattac aatttgataa aatttcaaat agctctattg ccctacttat 8401 agagtaatgt aagaaacaat gtaacttttc attataaaaa ttattttgca cttgccaaag 8461 gagattaagg agttaacttt ttttgtttta aacattcccc caaaatattt atcgtttggg 8521 ggttgaaaaa aatgcagccc attgaattgt gagttttaaa ctggaaaggt cacagattaa 8581 tggcatacaa ttaaacctgt ttttttgttt gtttttcttc tcaaaatgtt agccctaaac 8641 actgaattat tttcaaattt agacacccag gtgcttttta acttttgtac tttacagtta 8701 ctaacaagca ggtttgcata aggcattttt gagagccgga ctagcaggcc ataggtaatt 8761 ccgtgttgtc aacacgactt tccacaccag gagaggaaac tcccagggcc caaaggctaa 8821 agtggaatgg tcaagtcatt tgccattgag tcatagccag accatcccta tctagcaagc 8881 catgcctgct tcctggtttg tgcatgttgc cctgtgtgct cctccttaga actagagagc 8941 agcaatgcca gtgccttcac cagcaaatca agggatggta ggaagggata gggctttaga 9001 gatcatcact tactgccctc atttcacaag aggaaaaatg cccagtgaac ttaaggaatt 9061 tcccccaggt cacctaaact agttaggagc agacttaagc tagaaccaag gtcccctggc 9121 tcctttgcag ttggtgtcat tcattaaaaa gaagaataaa aagaactctt tttttcttaa 9181 agctgtcatc atcttgtgaa atatcagttt gcccttgact aggaaattac atcaaattaa 9241 accattcagt cccctagaat agcagtaggg ctggtttatt ctgaaaacct ttgctgggtc 9301 ttacatgcag ataacttgac tttccttctc ttctcctcct ttctgtcctc aggtgacggc 9361 aattgcctca tgcatgccac ttctcagtac atgtggggcg ttcaggacac agacttggta 9421 ctgaggaagg cgctgttcag cacgctcaag gaaacagaca cacgcaactt taaattccgc 9481 tggcaactgg agtctctcaa atctcaggaa tttgttgaaa cggggctttg ctatgatact 9541 cgggtaggtt tttcccccta attatctact aacagagctc catggtgggc atagggtacc 9601 cctgggcgag tccctgccct ctggtagcat ctgatggact aggtcacatg aatttggcta 9661 agcgaagcat actcaatgga aaacaccaga aacctccagt gggactcacc caaggctttt 9721 gccctgcttt tggttagcag attcccagct gtggatccgt tcctgtagca gcgagtcttt 9781 tgatcatggc cttttccact ggtgttttgt tgtttttcag tttgattgcc cttagctttg 9841 ctgagccagc cagtaagatt aagacacgtg cctcaccatc ctcagtcaca agtttggaat 9901 ttttgtgaac atttggataa ggggctgcaa tatgatacct catcagggat ttttttttaa 9961 aagcaggtgc tgtccccgtc ctccccaact tttgagtttg ccttgtagtg gaaaaaagta 10021 aaggaagaaa accgaaatgg ggaaaaaagg gtgatcattt gaatgatggt ttcatgaaag 10081 gggaaaaaat aagctgagtt atataaatga ataattgtag agtgatgtca gaatgacttt 10141 ttagtacagg gagtacagga tacattcaag cttttttttc accccgctcc ccttagaact 10201 ggaatgatga atgggacaat cttatcaaaa tggcttccac agacacaccc atggcccgaa 10261 gtggacttca gtacaactca ctggaagaaa tacacatatt tgtcctttgc aacatcctca 10321 gaaggccaat cattgtcatt tcaggtgaga tgcctgcaga tcacggatct gtacttaaat 10381 gctttcagcc ttatgccttg gctcctggag aaaaccacac tgccaaagtt caggtaacag 10441 agttcaatgg aatttgatga aagtcaccta agggcctcat tttcctttct ctttctttga 10501 acagacaaaa tgctaagaag tttggaatca ggttccaatt tcgccccttt gaaagtgggt 10561 ggaatttact tgcctctcca ctggcctgcc caggaatgct acagataccc cattgttctc 10621 ggctatgaca gccatcattt tgtacccttg gtgaccctga aggacagtgg gcctggtgag 10681 aaaactgcat taattcacat ctataactag acactgaaac atcagggttt tcctttttgc 10741 ttcttattaa aacagtctta tttaagtata ttatttttat ttaaatatat tgttctgtga 10801 cttgcttggt tagtaagagt aatgcagtag cagtaatcat aataccctca tatctttttg 10861 aatatgactt ggaaagtact ttcatacatg ataaattaag gcgcacagtg ctcttaatac 10921 agtgcctggt atggagcaag taaacgcctg tcaggttagt ttttttcttt ttgagacagg 10981 gtttccctcc attgtccagg ctggagtgca gtggcacaat catggctcat tgcagcctcc 11041 accccctggg ctcaagcagt ctctcgcttt ggcctctcaa atttacaggc acgagccacc 11101 atgcctggcc tgttagctgt tattttaata gcctcatgtg gaataagcac tgtgctttgg 11161 aaatattatt ttactgcatt tttatccttt tagcattctt gtgagatgta ggccttggta 11221 gccttatttt acatattaga cagttaaagc tcagagaggt caactaacct gcctaatgcc 11281 acacagcttg atagtgacaa agccaggatt caaactcagg tcagtctgat tctaaagcct 11341 gggactttaa ccaataagat ccaccacctc caggctggtt aatgttatgt gagtttcctg 11401 gaaacagtgc atttttatat tagattgtag cacattttgt tttcccattt gggtttaact 11461 gtggctaaga atacttttct attctgtaag ttatatcttt tatacatttt caaaatgaga 11521 tctacttacc tatggccttg tttagtagaa tactgtttta cttatgtatt atttttttcc 11581 ttagaaatcc gagctgttcc acttgttaac agagaccggg gaagatttga agacttaaaa 11641 gttcactttt tgacagatcc tgaaaatgag atgaaggaga agctcttaaa agagtactta 11701 atggtgatag aaatccccgt ccaaggctgg gaccatggca caactcatct catcaatgcc 11761 gcaaagtaag cagtttatgt tcagctctct cctgtgtcat ctgtaactgt ctttaacctc 11821 agccacctga gttgctgcca ccctgaagct caacagtaga gtgatttgcg gccagtttct 11881 gccaatggga aacaaattca gagtcttgtg catggttaga gaggattatg taaggcagta 11941 ctaacttggg tttcaaatca aaacatgtca tttatccata atgattttcc tggatatctg 12001 gatcccaaaa gtcagaattg cagaattatg ggttttcaaa gtgcatttac atcaaggata 12061 gttgttgttt cttgtttttg tattttaatt actctggtac atattaaaaa gactagtgaa 12121 aacacttgga aacaaaagcc tttctctctt ggcttcttgg taagaacagg cacatcagac 12181 atagatggag ctgtagaatt gtttatgttg cagctcatga ttctgccaca tggaaatggg 12241 aggaaagccc cagaataccc attgtgcagg tatccggtct ttaaacattg gctttatgtt 12301 aaagagatgc ctgtttctga gcacttgaaa cgcacaacag atgacaagga agccgtaaga 12361 gaatctgtct ctcaatgtgg agattagcaa attacagagt caacagtaaa tagacaagcg 12421 cctttgagtg tgtctgcgtc ttagttactc atggctgcta atgctggtgg agactagaca 12481 caagtttaaa gttagtaaca gcaaaatacc caacctgagg ttccaaagta gtttgtacta 12541 taaagtagac tagtcccaaa ccaatggcct cagtaatatt ttactcagaa tttgatctct 12601 gagaaattgg aaagtcaact gatttttctt agcccttgtt ttagaactat ctataatttt 12661 tggatggacc aagattgatt aaatgaaact gtgattttaa aaataaggaa gtcttagcaa 12721 actaactgac atcattcttg actcgaacat gttgggaaat gtgtcagatc atgttgcgtg 12781 aaaagtgtga gctcttcatc acaggcctgc atttcagtga atggttctac aattcttgcc 12841 ataatccaca ttctaaaact ttgttctatg agctaatgat gtaaaatctt gtgtgtgatt 12901 ttgtgtattc tcatacatat tttttccttt tggtcttcag gttggatgaa gctaacttac 12961 caaaagaaat caatctggta gatgattact ttgaacttgt tcagcatgag tacaagaaat 13021 ggcaggaaaa cagcgagcag gggaggagag aggggcacgc ccagaatccc atggaacctt 13081 ccgtgcccca gctttctctc atggatgtaa aatgtgaaac gcccaactgc cccttcttca 13141 tgtctgtgaa cacccagcct ttatgccatg agtgctcaga gaggcggcaa aagaatcaaa 13201 acaaactccc aaagctgaac tccaagccgg gccctgaggg gctccctggc atggcgctcg 13261 gggcctctcg gggagaagcc tatgagccct tggcgtggaa ccctgaggag tccactgggg 13321 ggcctcattc ggccccaccg acagcaccca gcccttttct gttcagtgag accactgcca 13381 tgaagtgcag gagccccggc tgccccttca cactgaatgt gcagcacaac ggattttgtg 13441 aacgttgcca caacgcccgg caacttcacg ccagccacgc cccagaccac acaaggcact 13501 tggatcccgg gaagtgccaa gcctgcctcc aggatgttac caggacattt aatgggatct 13561 gcagtacttg cttcaaaagg actacagcag aggcctcctc cagcctcagc accagcctcc 13621 ctccttcctg tcaccagcgt tccaagtcag atccctcgcg gctcgtccgg agcccctccc 13681 cgcattcttg ccacagagct ggaaacgacg cccctgctgg ctgcctgtct caagctgcac 13741 ggactcctgg ggacaggacg gggacgagca agtgcagaaa agccggctgc gtgtattttg 13801 ggactccaga aaacaagggc ttttgcacac tgtgtttcat cgagtacaga gaaaacaaac 13861 gtgagtgaag tggttgactt cctaacacag cggctgctgt ccagaagggg ttttgttcct 13921 gacctttaag aaaaaaagcc catgtaggca gtcaggcaga actgtcagga cctaccgtgc 13981 ttttctacca gcttgtgcag gggacagtca cggtggccct gccagccgcc catggaggca 14041 aaaggcactg cgtgattaca gcagctccta atatcacatt ccaaaaacca gagtgccctg 14101 tagacagagc tcatgggatg tgcttttact agaccattca ggtctggcat atctaagaga 14161 gtctaagttt aaactagact tattttgcaa cttagatata acagaacaat cttaaaatct 14221 gaagagtagt aactggagag aaggaagtct ctgttgacac tgtaaggaaa cagatgtggt 14281 ttggaaatct ctcattggaa agaagggtga tcaggtaatg cctgctcctt gcctgttcct 14341 gtgagcaatc agtgcttcaa gttcaaaatg agagattggt aaagccaaag atgtttccat 14401 aatagggatg ttatttcttt tgctgaattt atagacttaa acatatacat atatatattt 14461 ctatacattt aaggctggcc taatctgtat ttggaaccca tttatttctc tactgtcagc 14521 atctctgtat cggtggggtg acccctatgt ggtactaact agcatccatt ctcatgtaga 14581 ttttgctgct gcctcaggga aagtcagtcc cacagcgtcc aggttccaga acaccattcc 14641 gtgcctgggg agggaatgcg gcacccttgg aagcaccatg tttgaaggat actgccagaa 14701 gtgtttcatt gaagctcaga atcagagatt tcatgaggcc aaaaggacag aagagcaact 14761 ggtgagacac ttggaggagc tttccctccc tcccgtgtgt tcgatgcttt ttgctggagc 14821 gttttctacc gacagtgaca agcaggcttt cctctctgcc aggttctgtc tcctcatgat 14881 aaaggattaa ttcagaacct gaaggggaat gtccatgtca ctgtggctcc ccaggtccga 14941 aatgctacct ccaattttca tgctccaagt atgctttcaa atttatttta aaaacaaaga 15001 aacacagcca ttgcataaaa cttcttcaag cctccaaaaa gccagatggt gatcagaggc 15061 ttctttgatt tgtaagagaa gcacagacat ctaaaaagca gcccttctta aataatcctt 15121 tatcataagg agcgaacaga cagagcttcc caggggcctc cacctaatgg cgcgtcagaa 15181 aagccagctt tgacagatag gtgtgtcgcc tgttgctcac agaatggtag ggaagctatg 15241 taagaacagt ggtttttggt cccaacagaa gagagccagg gaaagtttgc aggccaactt 15301 aggcttggcg gttttcctca gcctccctgg gggccaagtc agctttcctt gagactggaa 15361 agaaacatcc ttcgagagct ctggctcata gactgcaatg ctctcctgtt cccttgctca 15421 ggcaggtaaa gctctttgta gactccacac tctccaatga gatttcattg tgctctccct 15481 aagaaatgtg agcaatagtt tcctgacttt ttaatgatct gcctgttctt tccactcaga 15541 gatcgagcca gcgcagagat gtgcctcgaa ccacacaaag cacctcaagg cccaagtgcg 15601 cccgggcctc ctgcaagaac atcctggcct gccgcagcga ggagctctgc atggagtgtc 15661 agcatcccaa ccagaggatg ggccctgggg cccaccgggg tgagcctgcc cccgaagacc 15721 cccccaagca gcgttgccgg gcccccgcct gtgatcattt tggcaatgcc aagtgcaacg 15781 gctactgcaa cgaatgcttt cagttcaagc agatgtatgg ctaaccggaa acaggtgggt 15841 cacctcctgc aagaagtggg gcctcgagct gtcagtcatc atggtgctat cctctgaacc 15901 cctcagctgc cactgcaaca gtgggcttaa gggtgtctga gcaggagagg aaagataagc 15961 tcttcgtggt gcccacgatg ctcaggtttg gtaacccggg agtgttccca ggtggcctta 16021 gaaagcaaag cttgtaactg gcaagggatg atgtcagatt cagcccaagg ttcctcctct 16081 cctaccaagc aggaggccag gaacttcttt ggacttggaa ggtgtgcggg gactggccga 16141 ggcccctgca ccctgcgcat caggactgct tcatcgtctt ggctgagaaa gggaaaagac 16201 acacaagtcg cgtgggttgg agaagccaga gccattccac ctcccctccc ccagcatctc 16261 tcagagatgt gaagccagat cctcatggca gcgaggccct ctgcaagaag ctcaaggaag 16321 ctcagggaaa atggacgtat tcagagagtg tttgtagttc atggtttttc cctacctgcc 16381 cggttccttt cctgaggacc cggcagaaat gcagaaccat ccatggactg tgattctgag 16441 gctgctgaga ctgaacatgt tcacattgac agaaaaacaa gctgctcttt ataatatgca 16501 ccttttaaaa aattagaata ttttactggg aagacgtgta actctttggg ttattactgt 16561 ctttacttct aaagaagtta gcttgaactg aggagtaaaa gtgtgtacat atataatata 16621 cccttacatt atgtatgagg gattttttta aattatattg aaatgctgcc ctagaagtac 16681 aataggaagg ctaaataata ataacctgtt ttctggttgt tgttggggca tgagcttgtg 16741 tatacactgc ttgcataaac tcaaccagct gcctttttaa agggagctct agtccttttt 16801 gtgtaattca ctttatttat tttattacaa acttcaagat tatttaagtg aagatatttc 16861 ttcagctctg gggaaaatgc cacagtgttc tcctgagaga acatccttgc tttgagtcag 16921 gctgtgggca agttcctgac cacagggagt aaattggcct ctttgataca cttttgcttg 16981 cctccccagg aaagaaggaa ttgcatccaa ggtatacata catattcatc gatgtttcgt 17041 gcttctcctt atgaaactcc agctatgtaa taaaaaacta tactctgtgt tctgttaatg 17101 cctctgagtg tcctacctcc ttggagatga gatagggaag gagcagggat gagactggca 17161 atggtcacag ggaaagatgt ggccttttgt gatggtttta ttttctgtta acactgtgtc 17221 ctgggggggc tgggaagtcc cctgcatccc atggtaccct ggtattggga cagcaaaagc 17281 cagtaaccat gagtatgagg aaatctcttt ctgttgctgg cttacagttt ctctgtgtgc 17341 tttgtggttg ctgtcatatt tgctctagaa gaaaaaaaaa aaaggagggg aaatgcattt 17401 tccccagaga taaaggctgc cattttgggg gtctgtactt atggcctgaa aatatttgtg 17461 atccataact ctacacagcc tttactcata ctattaggca cactttcccc ttagagcccc 17521 ctaagttttt cccagacgaa tctttataat ttctttccaa agataccaaa taaacttcag 17581 tgttttcatc taattctctt aaagttgata tcttaatatt ttgtgttgat cattatttcc 17641 attcttaatg tgaaaaaaag taattattta tacttattat aaaaagtatt tgaaatttgc 17701 acatttaatt gtccctaata gaaagccacc tattctttgt tggatttctt caagtttttc 17761 taaataaatg taacttttca caagagtcaa cattaaaaaa taaattattt aagaacagat 17821 tgtgatgttt tcaattgatg aatgctgaaa gaaaaagaaa ggcttggata ttaagactgt 17881 gcttcctaag cagctttatt ttgaggtgca cctgagcaat gcacacatct ctcatccatg 17941 gtagcaaggc agcttttcat aaataataac tgtatgaggt ccaggcccag tcctcaagca 18001 caagcccccg cttgacaatg aagacactct tcctctgatg ggaagaggaa agggatgcta 18061 ggaccctgtg gcccttttaa gcttcctgcc ctaaactttt ataaagtgaa gaaagagaaa 18121 acaagaggga ggaggaggga aagacaggaa agagagaagt aggcaggcag gaaggaagac 18181 tgatgtaaga tctcctgggt cagacaaagc agaggaggca gcgtggctgt gctggctgcc 18241 agaaccagga aattaaaaaa taacacattc ctccatgcgc aagccttcat ccccacctcc 18301 catccagtac aaatggactc acagacgact gattcagcag gactgcgcag ctcccagaat 18361 ctactttttt aagctcctcg ggtgatctgg atgatcagcc agattttaga atcacacttt 18421 aaaaaatata tttataattt ttttttaact ttttaaaagt agaaaacttt aataagaaag 18481 tgacaagtac tataaagagc cactctatag ccatcctcca gtttcaataa ttaccaacgt 18541 tctgcccaat ttgtttcatc tatcacatcc tcttttttgt ttttcctgga ctacttgaaa 18601 gcaaatccca gatattgtgt cttcataccc ataaatattt cagtgtgcac ctctaattga 18661 atagaatatg tccttttaac ataaccacca ttatcagagc cagctaaatt attttattct 18721 ttaatatcca aattccaagt atgtattcta atttctcagt ttatccacca tacaagacaa 18781 agtcttattg ctttcgttta gtaaggatct tttctttttt ttttaatgtt tagcaatatt 18841 tattaggacg tatacctacc ttatgatcca aaaattccaa tcctaggtat acactcaatg 18901 gtatacactc tactcctagc tatacaccca taaaacagaa atgcatgcat atgttcacca 18961 aaatatggta ctaaaatgtt catctcagca gtattcataa tagctccaaa ctacaaacga 19021 tccaaatgtt cattaacagg agaaaagaga aatatattgt ggtatattca tataatggat 19081 tatcatatag cagtaagagt gaataggcac ctgtagttcc agctactcag gaggctgagg 19141 tgggagaact gcttaaggct acagtgagtt ataaggctct atttatttat ttatttattt 19201 ttgagacaga gtctttttta aatttttttt tattatactt taagttctgg gatacatgtg 19261 tagaacgttc aggtttgtta cataggtata catgtgccat agtggtttgc tgcacccatc 19321 aacccatcat ctacattagg tatttctact aatgctgtgc ctctcctagc ccccctaccc 19381 cgtgacaggc cccagtgtgt gatgttccct tccctgtgtc catgtgttct cattgttcaa 19441 ctcccactta taagtgagaa catgcagtgt ctggttttct gttcctgtgt tagtttgctg 19501 agaatgatgg tttccagctt catccatggc tttgcaaagg acatgaactc atcctttttt 19561 atggctgcat agtattccat ggtgtatatg tgccacattt tctttatcca gtctatcatt 19621 gatgggcatt tggttggttc caagtctttg ctattgtgaa tagtgcccca ataaacatac 19681 atcatacatg tgcatgtgtc tttatagtag catgatttat aatcctttgg gtatataccc 19741 agtaatggga ttactgggtc aagtcgtatt tctggttcta gatccttgag gaattgccac 19801 actgtcttct //