LOCUS AY282416 20684 bp DNA linear PRI 12-MAY-2003 DEFINITION Homo sapiens Toll-interleukin 1 receptor (TIR) domain-containing adapter protein (TIRAP) gene, complete cds. ACCESSION AY282416 VERSION AY282416.1 GI:30526339 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 20684) AUTHORS Rieder,M.J., Carrington,D.P., da Ponte,S.H., Hastings,N.C., Ahearn,M.O., Kuldanek,S.A., Rajkumar,N., Toth,E.J., Yi,Q. and Nickerson,D.A. TITLE Direct Submission JOURNAL Submitted (23-APR-2003) Genome Sciences, University of Washington, 1705 NE Pacific, Seattle, WA 98195, USA COMMENT To cite this work please use: SeattleSNPs. NHLBI HL66682 Program for Genomic Applications, UW-FHCRC, Seattle, WA (URL: http://pga.gs.washington.edu). FEATURES Location/Qualifiers source 1..20684 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" variation 154 /frequency="0.35" /replace="c" repeat_region 169..603 /rpt_family="L2" /rpt_type=dispersed variation 423 /frequency="0.13" /replace="t" variation 508 /frequency="0.01" /replace="t" repeat_region 694..1003 /rpt_family="Alu" /rpt_type=dispersed variation 700 /frequency="0.01" /replace="t" repeat_region 1384..1660 /rpt_family="Alu" /rpt_type=dispersed variation 1576 /frequency="0.17" /replace="t" variation 1745 /frequency="0.15" /replace="c" variation 1750 /frequency="0.17" /replace="g" variation 1751 /frequency="0.04" /replace="g" variation 1925 /frequency="0.15" /replace="g" variation 2018 /frequency="0.09" /replace="a" variation 2021 /frequency="0.01" /replace="g" variation 2028 /frequency="0.01" /replace="a" variation 2040 /frequency="0.02" /replace="" variation 2048 /frequency="0.04" /replace="a" variation 2275..2284 /frequency="0.58" /replace="" repeat_region 2309..2483 /rpt_family="MIR" /rpt_type=dispersed repeat_region 3045..3161 /rpt_family="MIR" /rpt_type=dispersed misc_feature 3101..3393 /note="Region not scanned for variation" gene 3505..17994 /gene="TIRAP" mRNA join(3505..3551,10063..10231,10860..10983,11201..11359, 12875..13453,14066..14090,14355..14694,17314..17994) /gene="TIRAP" /product="Toll-interleukin 1 receptor (TIR) domain-containing adapter protein" variation 3682 /gene="TIRAP" /frequency="0.41" /replace="t" variation 3846 /gene="TIRAP" /frequency="0.06" /replace="a" variation 3903 /gene="TIRAP" /frequency="0.01" /replace="a" variation 3906 /gene="TIRAP" /frequency="0.01" /replace="g" variation 4346 /gene="TIRAP" /frequency="0.14" /replace="g" variation 4378 /gene="TIRAP" /frequency="0.12" /replace="g" repeat_region 4379..4428 /rpt_family="L1" /rpt_type=dispersed repeat_region 4429..4731 /rpt_family="Alu" /rpt_type=dispersed misc_feature 4448..4794 /gene="TIRAP" /note="Region not scanned for variation" repeat_region 4732..4971 /rpt_family="L1" /rpt_type=dispersed variation 4888 /gene="TIRAP" /frequency="0.12" /replace="" repeat_region 4972..5268 /rpt_family="Alu" /rpt_type=dispersed variation 5035 /gene="TIRAP" /frequency="0.16" /replace="t" variation 5080 /gene="TIRAP" /frequency="0.05" /replace="t" repeat_region 5269..5564 /rpt_family="L1" /rpt_type=dispersed repeat_region 5667..5957 /rpt_family="Alu" /rpt_type=dispersed variation 5843 /gene="TIRAP" /frequency="0.09" /replace="g" variation 5883 /gene="TIRAP" /frequency="0.01" /replace="t" repeat_region 5961..6125 /rpt_family="L1" /rpt_type=dispersed repeat_region 6154..6476 /rpt_family="Alu" /rpt_type=dispersed variation 6227 /gene="TIRAP" /frequency="0.01" /replace="t" variation 6420 /gene="TIRAP" /frequency="0.11" /replace="t" repeat_region 6477..6773 /rpt_family="Alu" /rpt_type=dispersed variation 7001 /gene="TIRAP" /frequency="0.01" /replace="t" repeat_region 7160..7572 /rpt_family="MaLR" /rpt_type=dispersed variation 7370 /gene="TIRAP" /frequency="0.01" /replace="a" variation 7482 /gene="TIRAP" /frequency="0.19" /replace="t" repeat_region 7717..8016 /rpt_family="Alu" /rpt_type=dispersed variation 7865 /gene="TIRAP" /frequency="0.01" /replace="t" variation 7880..7885 /gene="TIRAP" /frequency="0.02" /replace="" repeat_region 8149..8451 /rpt_family="Alu" /rpt_type=dispersed variation 8397 /gene="TIRAP" /frequency="0.01" /replace="t" variation 8413 /gene="TIRAP" /frequency="0.03" /replace="g" repeat_region 8452..8574 /rpt_family="Alu" /rpt_type=dispersed variation 8764 /gene="TIRAP" /frequency="0.04" /replace="a" variation 9537 /gene="TIRAP" /frequency="0.45" /replace="c" repeat_region 9675..9975 /rpt_family="Alu" /rpt_type=dispersed repeat_region 10252..10441 /rpt_family="L1" /rpt_type=dispersed variation 10363 /gene="TIRAP" /frequency="0.15" /replace="t" variation 10374 /gene="TIRAP" /frequency="0.01" /replace="a" variation 10378 /gene="TIRAP" /frequency="0.01" /replace="t" repeat_region 10448..10663 /rpt_family="MIR" /rpt_type=dispersed variation 10509 /gene="TIRAP" /frequency="0.09" /replace="c" variation 10969 /gene="TIRAP" /frequency="0.01" /replace="t" variation 11190 /gene="TIRAP" /frequency="0.11" /replace="g" CDS join(11293..11359,12875..13453,14066..14085) /gene="TIRAP" /codon_start=1 /product="Toll-interleukin 1 receptor (TIR) domain-containing adapter protein" /protein_id="AAP31973.1" /db_xref="GI:30526340" /translation="MASSTSLPAPGSRPKKPLGKMADWFRQTLLKKPKKRPNSPESTS SDASQPTSQDSPLPPSLSSVTSPSLPPTHASDSGSSRWSKDYDVCVCHSEEDLVAAQD LVSYLEGSTASLRCFLQLRDATPGGAIVSELCQALSSSHCRVLLITPGFLQDPWCKYQ MLQALTEAPGAEGCTIPLLSGLSRAAYPPELRFMYYVDGRGPDGGFRQVKEAVMRYLQ TLS" variation 11317 /gene="TIRAP" /frequency="0.01" /replace="c" variation 11329 /gene="TIRAP" /frequency="0.01" /replace="t" variation 11530..11533 /gene="TIRAP" /frequency="0.91" /replace="" variation 11877 /gene="TIRAP" /frequency="0.11" /replace="t" variation 11967 /gene="TIRAP" /frequency="0.01" /replace="g" variation 11983 /gene="TIRAP" /frequency="0.01" /replace="t" variation 11993 /gene="TIRAP" /frequency="0.38" /replace="t" repeat_region 12423..12717 /rpt_family="Alu" /rpt_type=dispersed variation 12724 /gene="TIRAP" /frequency="0.20" /replace="c" variation 13093 /gene="TIRAP" /frequency="0.01" /replace="a" variation 13110 /gene="TIRAP" /frequency="0.09" /replace="a" variation 13346 /gene="TIRAP" /frequency="0.09" /replace="t" variation 13365 /gene="TIRAP" /frequency="0.17" /replace="t" repeat_region 13533..13738 /rpt_family="MIR" /rpt_type=dispersed variation 13567 /gene="TIRAP" /frequency="0.08" /replace="g" variation 13627 /gene="TIRAP" /frequency="0.36" /replace="c" variation 14115 /gene="TIRAP" /frequency="0.15" /replace="g" variation 14193 /gene="TIRAP" /frequency="0.02" /replace="t" variation 14194 /gene="TIRAP" /frequency="0.36" /replace="a" variation 14852 /gene="TIRAP" /frequency="0.19" /replace="t" repeat_region 15213..15506 /rpt_family="Alu" /rpt_type=dispersed variation 15309 /gene="TIRAP" /frequency="0.08" /replace="c" repeat_region 15507..15804 /rpt_family="Alu" /rpt_type=dispersed variation 15792 /gene="TIRAP" /frequency="0.04" /replace="g" repeat_region 15845..16331 /rpt_family="L1" /rpt_type=dispersed variation 15935 /gene="TIRAP" /frequency="0.10" /replace="t" variation 15996 /gene="TIRAP" /frequency="0.02" /replace="t" variation 16003 /gene="TIRAP" /frequency="0.08" /replace="c" variation 16069 /gene="TIRAP" /frequency="0.14" /replace="a" variation 16228 /gene="TIRAP" /frequency="0.01" /replace="c" variation 16260 /gene="TIRAP" /frequency="0.19" /replace="c" repeat_region 16332..16635 /rpt_family="Alu" /rpt_type=dispersed variation 16385 /gene="TIRAP" /frequency="0.03" /replace="a" repeat_region 16636..16841 /rpt_family="L1" /rpt_type=dispersed repeat_region 16827..17039 /rpt_family="L1" /rpt_type=dispersed variation 16971 /gene="TIRAP" /frequency="0.10" /replace="a" repeat_region 17050..17349 /rpt_family="Alu" /rpt_type=dispersed variation 17080 /gene="TIRAP" /frequency="0.36" /replace="a" variation 17277 /gene="TIRAP" /frequency="0.02" /replace="c" repeat_region 17394..18051 /rpt_family="L1" /rpt_type=dispersed variation 17460 /gene="TIRAP" /frequency="0.01" /replace="g" variation 17644..17648 /gene="TIRAP" /frequency="0.64" /replace="" variation 17687 /gene="TIRAP" /frequency="0.08" /replace="a" variation 17937 /gene="TIRAP" /frequency="0.01" /replace="g" variation 17977 /gene="TIRAP" /frequency="0.11" /replace="t" repeat_region 18163..18440 /rpt_family="Alu" /rpt_type=dispersed variation 18199 /frequency="0.18" /replace="t" variation 18223 /frequency="0.14" /replace="t" repeat_region 18534..18622 /rpt_family="L1" /rpt_type=dispersed repeat_region 18631..18927 /rpt_family="Alu" /rpt_type=dispersed variation 18690 /frequency="0.02" /replace="a" variation 18865 /frequency="0.34" /replace="t" repeat_region 18938..19026 /rpt_family="L1" /rpt_type=dispersed repeat_region 19029..19094 /rpt_family="Alu" /rpt_type=dispersed variation 19085 /frequency="0.11" /replace="t" repeat_region 19230..19353 /rpt_family="L1" /rpt_type=dispersed repeat_region 19446..19754 /rpt_family="Alu" /rpt_type=dispersed variation 19495 /frequency="0.13" /replace="g" variation 19512 /frequency="0.33" /replace="a" variation 19527 /frequency="0.09" /replace="t" variation 19724 /frequency="0.09" /replace="t" repeat_region 19885..20103 /rpt_family="L1" /rpt_type=dispersed repeat_region 20155..20451 /rpt_family="Alu" /rpt_type=dispersed variation 20338 /frequency="0.02" /replace="g" variation 20353 /frequency="0.14" /replace="t" repeat_region 20524..20647 /rpt_family="MER1_type" /rpt_type=dispersed ORIGIN 1 agagcagatg aggatgtcaa ggcaggcagc aaggaggcca gatggaggct gtggttgcag 61 tctgtgtggc agggacaggg agtgcctgaa ccatcatggc aagaatcaga tggatcccag 121 ggtgacgcca gcaacaagaa gtgggttaag tcggatggcc aggtttctgg atggaggttc 181 tacccctccc agagatgagg agcaccaggg aggagcggag tgagggacag agtgaatggt 241 gcagtctggg atgtggtgaa tgagggtacc tgtaggacat ccctcaaata gggggttggg 301 ctgattggca tggtccttgg gggatgatct gggctgtaga tagtgatgtg gacatcatgg 361 aacaggatgg catcacccca gagggtagag tagggggcca aggagggaag ctggagggac 421 cccaccaaca tttaagggac agaccagaga aggggacact gaagaggtgc ccacagagac 481 aggagaaaag ccaggagagt gtggtgtcgt gaagctaagg aggaagtgat cacggtgcct 541 gctggattcg gtcccaagta ggtcagtggt ggcctcactc gagaagagca gtttcagtgg 601 aatttaaggt ctggacactt gcacaggaga agtgaatggg aatagaaaca gctggtaaac 661 tgcccactcc gccttgaaag tggcctttgg gatcgggcgc ggtggctcac agttgtaatc 721 ccaggactct gggaggccga ggtgggaaga tcgcttgagc ctacgagttc gagaccagct 781 tgggcaacat ggcaaaatcc tgtctctaca aaaaatacaa aaattagcca agcgtggtgg 841 catgcacctg tagtcccagc tattaatacg tgggaggctg aggcaggagg atcacttgag 901 ccttggaggt tgaggctgca gtgagctgtg aggcaccact gcactccagc ctgggtgaag 961 gagtaagacc ctatctcaaa aacaaaaaac gacaacagaa aaagtggcct ttgtggagaa 1021 ggatgaaagg gagggaagaa atgatggagg tgggctttac taatggcagg ggaggagatg 1081 tgctaccagt gaggtaacag cagaagcccc tgaggttggg gtgagggggc caggcctaag 1141 gcggaagcca gaagaggaag aaggcggtgc tgaaagacag gaaggaactt gccagggata 1201 cgcaggaggg acaagctgac atccgggttg accctgtgaa gttcccctag gtgccagcca 1261 gttgctccct tcagcacgga cattccaatc tcagggcaaa agggaaaagg ccttcaagtg 1321 tttctcaccc agaagctgct cccttccaca cactgagtac tatgtttatt aagaagcact 1381 gaggcctgta atcccagcac tttgggaggc ggaggtgggc agatcacctc aggtcaggag 1441 ttcgagacca gcctgaccaa cacggagaac tcctgtctct agtaaaaata caaaattagc 1501 cgggcatggt ggcgtgtgcc tgtaattcca gctactcagg aggcagaggc aggagaattg 1561 cttgaaccct ggaggcggag gttgcagtga gctgagattg cgccattgca ctccagcctg 1621 ggcaacaaga gtgaaactcc atctcaaaaa aaaaaaaaaa gcactgagca actctcctgt 1681 cctcccacag ggctgtactt caagctgtgg gcaagccctt accatcgcct ccgtgcatct 1741 gtcttccccc ctgagctgtg cagagctggg accaagcctt cttcatcctt gcctgacact 1801 cagctgcccc aacacttggc ccatacttgg cgccgtcaag gcctgtttat ctgagtgttc 1861 ctcgagtgtc cttctgctct ggctggagcc tgaagaacca tccctggcct cggggaattt 1921 ttactctaaa gtgggagata agcagcagag cacaggctct ttacaatgaa aagcactatg 1981 gcctttgagg gatggaggtg ggaagggctg ggttaagcaa agctttcctg aataagctgc 2041 aaaaatgggc cttgatccct ttgtagctca taagcaagat gactgggtgt tcacgcacat 2101 gtgtgaggtg tgcctccctt aaaccttgtt aagggttgtt acccgtgtga tgggaaaaaa 2161 aagaaaaagg aaacaaaaaa accccaaaaa taggccttgc tagaagaagg gcgttttgca 2221 gagcggagct ggggaaaagg agggccctgg gcggaggtgt acttggtaga gtcaggtaga 2281 gtcaaagcaa actgggcatt tgggtgcagt gccaagtgcc tgatctactt tatgtagact 2341 aatccttgca agaacaccag caaccagata ccataatgtg atgaaggaag caagcctaga 2401 aaagttgcgt gacttcacca aggccacaca actagtaagc gatgagcgct ggttgtgaac 2461 ccaggcagtt gactccagag ccctcccagg atgggcagct catccgcttt ggcgggctgg 2521 tgagaaaagg aggaaatcaa attggagggg gagatcatga atcttacatg gcctaattaa 2581 actacctcca ctctccagca tttcgtgcac atagttttag gatagggttt cccaaactgg 2641 catggcctgg agcaagacgc tcaggaagac attcacattt cttgtagagt gaaacaagtg 2701 tggggaatgc tccgttccct tctccccaag gtgcttcaca gcgctcacga acatctgaag 2761 agctctcaga agtgggaggc aaaggcatct ctttcaccca ggacttccag catcttgcct 2821 acaccacgct gtttgcagcg gctctgcagc atactgcagc gctgttcata acgcccatgt 2881 gggatcaccg cttagagaag caaagaaagc actttggcag aagacggggt ttccaccctc 2941 ctcggcatca accagtgtct gggacgggaa ctggcggccg ctgcggcctg gcttcccagc 3001 tgccgcccgg gtctgcccct cccacactgc agccccgtac acccctcgct gtgtgtgacc 3061 tttggaaaag ttccatctct ccaagcttca tgtttctcat ttgtataaaa ggaaaaaggt 3121 atgaacaccc cccttgcagg gtgttaggaa gattaaatgg gcggaatagg gtgttttttt 3181 ttccttctcc cccgcctaga acaaaaccca ggtttcaggt tgtcacggtg ggcgccgggg 3241 gaccctggcc acgggctcct ctccgagttg ctgcggaccg ccccaacgca agcggagagg 3301 acgggagccc ggagtcatgc agaagccagg ctggcagggg ctcgggccgc agtggacaca 3361 ggggctgccc cgtcccgcgt ctcccgcagc cggattgtgc ccgagagtct cccgggtctg 3421 gactgggcct ggcggcgtgg gaggggcagt gcggcgggcg gcgcttccgg agagcggggc 3481 ctgcgcgctg ctcttccccg cggagcccgc gcagtccgcg cagccctcat cgcaactggg 3541 cccgcgcgca ggtgagcccg gggcggggtc gcgggggacc gggaggcgcg gcggggctcc 3601 gtggggtggg cgacggagcg cggccggcct gggccccaga gtcccggccc caccgagagc 3661 cgcaggggtg cgcgccgcct ccggtccggc cttgccctgc tggcggcaca tccgcttccc 3721 ttcttcacct ttctggcacc cgcaacacgc aagcggcatg aaagggccct ccgaggagaa 3781 tgtcaccttt tctgtcgcaa agaagctcgc gcggggcggc tcccctttcg cttgcctcgc 3841 tggaagagcc tggcgctcag tgcgttgtgg atatcgtttc tcctcacgtt cttctctgct 3901 ccggtcacag cctcttcctc tgctcttcgg gttgtcattg tggcagtgat tcagcaagtg 3961 cataacatta gttagggtca gggacctatc gaggcattac accacagtca tgggcagcta 4021 cacacgggct gggcagccac tgtgccaacg actagggtga ccgcggtgga ccagacagat 4081 ccagtcttct ggtccccagg ggacagacag gtacgctaga atcacagcat accctagaag 4141 tgcaacagag agggggaagt gtggagaact cccgttgaaa caccaaacct aggggacacc 4201 aggatcagga atgactcaga gggaaccaca tctagttagt ttttagattt aaaagagttg 4261 atacgtaggc acacaaatcc taagtgtaca gctcaaccat tttccacaac acgcacattt 4321 cctgattcag agcaatcaat aaaacatgac tacatccctg gcttctaacg ccataaaata 4381 ggtttgcctg ttttggattt tccatccatg gaatcatata tcatgtactt cttttttttt 4441 tttttttttt tgagatggag tttcgccttt gtcctctggg ctggagtgca gtggcgcaat 4501 ctcggttcac tgcagcctcc gccttgtggg ttcaagcgat tctcctgcct cctcccgagt 4561 agctgggatt acaggcgcct gccaccacgc ccggctaatt gttgcatttt cagtagcgac 4621 ggggtttcgc catattggcc agggtggtct cgaactcctg aactcaggtg atccgcctgc 4681 ctcagccttc cagagtgctg ggattacagg cgtgaaccac tgcgcccagc ccttcatgta 4741 ctcttacgtg tgtgacgtct gacattcagt atgttttgtg atattcaccc atgtttagtt 4801 agcagtttat tcttgttggt atataatatt ccattgtatg gctagaccac aatttattta 4861 tccattctac tggacacggg ttgatggaca gtcgtttcca ctgtggggtt attttgtatc 4921 ttgctgctac agacattctt gtgaatgtct tttggtaaac atctgtaagc aggcggggaa 4981 cagtggctca cacctgtaat cccagcactt tgggaggctg aggcaggcag attacgaggt 5041 caggagttcg agaccagcct agtcaatatg gtgaaacccc gtctctacta aaaatacaaa 5101 aatcagccag gcgtgatggc gggtgtcggt agtcccagct atttgggagg ttgaggcagg 5161 agaatcgctt gaacgtggga ggcagaggtt gcagggagcc gagattatgc cactgcactc 5221 cagcccgggc gacagaggga gactccgtct caaaaaaaaa aaaaaaaata tgtaagcact 5281 gctgtttgag tatattcgta ggactgaaat tgctgatgtg tgtatgctca tcttagtcta 5341 tggccaaaca cttctccacc ggcagtgttc gagttcccat ccctgcacac tcttaccact 5401 acttgatagt ctttttctct gtagccattt ggctgagtgc ccagcagtga tgcattgagg 5461 ttttagtttg catttctctg atgactaatg aactgttttg atgtctattg ctcatttgaa 5521 tattcctttt gtgaagtgcc tgctcaattc ttctgctcat ttttctgtcg tcttactagt 5581 tccattgagt ccttgaaata tttgtgatat aagacattta ttggatatat gtgtgtgtgt 5641 gtatatatat atatatataa tatatatttt atttgatttt tgagacggag tctctgtcac 5701 ccaggctgca gtgcaatggc gcagtctcag ctcactgcaa cctccgtctc ccaggttcaa 5761 gcgattctcc tgctttagcc tcccgagtag ctgggattac aggcacctgc caccacaccc 5821 agctaatttt tgtattttta gtagagatgg ggtttcacca tgttggccag gctgatcttg 5881 aactcctgac ctagttatcc gcccgcctcg gcctcccaaa gtgccgggat tacaggtgtg 5941 agccactgtg cccagccctg gatatatatt tttaaacatt ttaaccctcg ggagattgcc 6001 ttttcactct cctatttatg tcttttgatg aacagaagtt cttcattcta atgtttttta 6061 ttttatcatt ttttcccctt atagttgtat tatttgagtc tggtttttaa aaaatcttcc 6121 ctagcaagaa gactcagata aaagtaaaat taaagctggg catggtggct catgcctgta 6181 atcccagcac tttgggaggc tgaggtgggc ggatcacttg aggccacgag ttaggagacc 6241 agcttggcca acaaagcaag atcctgtctg taccaagaaa aattaaaaaa tgaaaaaaat 6301 aaattaggta ggtgtggtgg ctcacgtctt taattccagc tactctagag gttgagatgg 6361 aagactgctt gagccttgga ggttgaggct gcagtgagct gtaatcacaa cactgcactc 6421 cagcctgggt gacagagcaa gaccctctct ggaaaaaaaa aaaaaaaaaa aaaaaaggtc 6481 gggtgtggtg gctcatgcct gtatgtaatc ccagcacttt gggaggttga ggtgggccaa 6541 tcacttgagg tcatgagttc cagaccagcc tggtcaacat ggtaaaacct cgtgtctact 6601 aaaaatacaa aaattagctg gatgtggtgg cgagcacctg tagtcccagc tactcaggag 6661 gctgaggcac aagaatcact tgaacccagg aggcagaggt tgcagtgagc tgagattgtg 6721 ccactgcact ccagcctggg taatggaatg agtctgtctg aaaaaaaaag aaagtcatgg 6781 gtccttctca cagtcccagg tgtgaacaca gggggccacc ctaggtctgc accatagtct 6841 acaaacctct ttgagaacac tgtgttgtgt ctatcaagct ataaatgaat tatattcagg 6901 actttaagtg acattgtcct gcaaaccata attaatccta cccaaacgtt ttagcaagtg 6961 tttgagaaca aaacagcctt tgaaaccaaa attcttttaa atgtaaagtc aaagtcaggt 7021 gaagtataga tggtaattta tttatttaaa gatgtaaaaa ctgtttcaaa caatttgaac 7081 ctttaaacag accaggtttt agcactcaac tgaaatccaa tactttctcc attcattggc 7141 ctgatctaat cagacacagt gtagtagttt cctattgctg ctgtaacaaa ttgccacaaa 7201 cttagtggcc tcaaacaaca cacattgatt atcctgccgt tctaagatgg gtcagcaagg 7261 ccgtgctcct tctgaaggct ccaggaaaga acccatggac ttgccttttc cagcttctag 7321 aggccacctg catcccactg ccgcctgctt cccttggcac agctctttcg tctgcctcag 7381 accttcctgc ctccctcttg aaaggatctt tgtggttaca ttaaactcac ctgggtaatc 7441 caggaatccc tccccatcac aaggttctta atcacagctg ccgaatcccc ttttgccacg 7501 gaaggtaaca tattctcagt tccggggatt aggatgtggg cctctttgtg ggccactatt 7561 ctgtctaccc cagatagtga ttcctgctta acagaaatcg aatatgaact ctaagagata 7621 catattctaa ttatatgcct tcacaggctc cagtacattc cctatataat agaaattgga 7681 gaccagtttg atattggata ctaaatacac tttggatttt ttttttttta tttttgagac 7741 ttgagtcttg ctctgttgcc caggctggag tgcagtggca tgatctcggc tcactgcaac 7801 ctccacctcc cgggttcaag tgattctcct gcctcagcct cctgagcagc tgggattaca 7861 ggcacgcacc accacgctta gctaattttt gtatttttag tagagacagg gtttcaccat 7921 gttggccagg ctgatctcaa attcctgacc tcatgatccg cccacctcgg cctcccaaag 7981 tgctgggatt acaggcatga gccactgtgc ccagcccact ttggatttta tacagcaaaa 8041 ctccataatg tttcctttac atcagtttct gcacataata ttggaaaagc attctagaaa 8101 gcactaaagg tattgtgcta cttcttttct gaagaaattc tttactaatt ttcttttctt 8161 tatttttttg agatcgagtc tcgctctgtc acccaggctg gagcacagtg gtgcaatctc 8221 ggctcactgc aacctctgcc tcccaggttc aagggattat ccagcctcag ccacccaagt 8281 agctaggatt acaggtgtgc gacaccatgc ctggctaatt tttgtatttt tagtagagac 8341 agggtttcga cctgtcggcc aggctggtct tgaactcctg agctcacatg atctgcccac 8401 ctcggcctcc caaagtgctg ggattacagg ggagcaccag cacacccggc taaattttgt 8461 atttttagta gagaaggggt tttgacaggc tggtctggaa ctcctgagct cacatgatct 8521 gcccacctcg gcctcccaaa gtgctgggat tacaggcatg agccactgag cccgttccct 8581 ttactaattt tctatcaagt catagttctt acaaagtggg tatttttggt atgattctac 8641 tttatgaatt ttttcaaagc acaaagaaag cgactgcgta ttagaccaca cagcaaatca 8701 gagaataggc agagctagtg agtagagctt ccagttggag atttgggttc attaccttac 8761 ctacttgtca accacatctc aagatatgat gacagttacc aggtcttgga aagattaaca 8821 cgtgtttgaa tatgtgacag ttccacagct ccagctacaa aagaactgaa aaggaacagg 8881 gaaggtgcat ggcgtcttgg attccaggaa gtaggcagtg tgtatggtta ctggaattta 8941 cctgccatct tgctcaatta tcctgtcaaa ggtgctgtta tttttctctt taaaacgttt 9001 ccatgtttct catgagggct tataccaccg cacttctggt ggcatatact gctggacaac 9061 tggatttctt cttaaccaag caatggaaaa gcaatttccc ccaattagca tgcgttgcca 9121 aaagggcaag tcatttcata aaatgagaaa ctgaaacttt aaaatctaca tatattaagt 9181 agattaacat attatgttaa tttttaacct ttagaatatt tacaaatcaa atgatgctct 9241 agtttacaag tgcaccaagg ccaaataatt aatattaaaa ttaaaacaga attgaaaaaa 9301 tatttaaaaa atgcaaaaac caagtgacat catgtttact actgggggca aaaaggcatc 9361 ctgaacggcc ctagctgcag cctaccactt aggctgtctg aaatcccaag catattagga 9421 aagaaaagaa actcatatac atactcatag tcaacgtcca gtgccgtttt ggtggcttca 9481 catttagctg tgttgctttt tcagatgtct tctctggttc ctgtacccat tccaactctt 9541 tgctctgcct cctttgctgc tatggtttaa gttctacttc ttttttgaac tttgatatat 9601 gatcacaaat cctcagcatc ccttgtcttc tacgcatcag tgaacaaagc attaatgtgc 9661 agcatagaat gacattcttt aatttttttt attgagatgg agtttcgctc ttgttgccca 9721 ggctggagtg cagtggtata atctcagctc actgcaacct ccgcctccag gttcaagaga 9781 ttcttctgcc tcagcctccc aagtagctgg gattataggc gcctgccacc atgcccagct 9841 aatttttgta ttttcagtag agacaggggt tttaccatgt tggccaggct aggcttgaac 9901 tcctgacttc aggtgatccg ccgccttggc ctcccaaaat gctaggatta caggcgtgag 9961 ccattgtgcc tggccacatt ctttaaattt tgaaaccttt tattttagtg tgtctaataa 10021 tacttgcttc catgagttct caggtttgtt ttgatctcac agatccacca aagagaaagc 10081 agccctgtgc cagttgctct gccagccttt cacaggagaa gtgtcactag aatactacag 10141 cccccacagg ctctgctcca cagaaactta aggctgaaag agtgtccgcc atcagggaca 10201 tcctctgtca ctacggtggg aaaagaacat ggcaggttgc ctttctaagg gattcttggg 10261 cctttgtatt tccatataaa tttagaagca gtctgacaac ctccccacca aaaaacctaa 10321 aaaacaaaaa tcttctagac tttggaacag cactgaatta atgatcagtt tgggaaacgt 10381 taacattaca agtttaataa accatgaaca taatataccc ctccaatatc tagattattt 10441 tatatacata gtagcccaca ttttctaagc atttattaca tgccaggcac cattaggact 10501 ttacataaat gatttcattt aatcttcaca ataatgctga gaaggaggct ctagtacttc 10561 catttcacgg atggagaaac gagtttagca aggtggccaa aggtcacggt taaccagaga 10621 tgagaatcag gcactctacc tgcagtctgc agtctgtacc actttttgac atgaccttcc 10681 tgagctgacg gctgcagggg cgatgggtct atggatggag ttattcaggg ggaggcagac 10741 ttggaggaaa agtctcccaa gatttcctgc atgtgctctc tctctactgt tcagcttctg 10801 tctatctgga tacataatta tttgtccaaa tagcaactgt ccttcttctg ccatttcagg 10861 ccttacatag gaagtccttc taaagagctg cctgccagct gcccttcccc agatcccgaa 10921 tatcctcctg gccaggtgga gcagagaaca gttcctcagc tggtcatgct gagctcatac 10981 cctgtaagtc tgaccacact acacagcttt ggctttatct agaatccagc tccaatcaca 11041 gtcgtgtctg gccctaatct catgaggaat gaaagaccca tttagagaag aagcctctgt 11101 caggcattag gagagaaaca gaacttcgca gagctcatcc atggggaatg agagcagggt 11161 aagtgcagcc tttgtgattc tctctctcta ccctctgtag gatggctgct ccatgaggtc 11221 aagactgggt ctcctccctc ctcccccttc accaatgcct ggtctcacgg ggctagtttt 11281 gacccccacg ctatggcatc atcgacctcc ctcccagctc ctggctctcg gcctaagaag 11341 cctctaggca agatggctgg tgagtggaac cggactcgcg actctgctgt gttcctgagt 11401 gtagtgctca gcctccatag ggcgcggtgg gaggcctgcc tggtccaaac tcagagagac 11461 gcaggaaggc tgacgtgggg aactcctgac ctgaattcag ggcctggatg ctttgtggag 11521 agtgaggagg ggaggcctgc gtcagctcag ccagatcttt atccttttgg ctcaaaggtt 11581 ttccaggcct gctcagctag ctttcctagc ctggaaacca ctgtgctgag tgcttaacac 11641 tgtctcttgt cgtccaaatc tttgttccag aaccatttag aggagaagcc aagcagagag 11701 agaaaatgaa tcaatcccca ccacaactat ctgtccttat caaaggctgg ggaagctgtt 11761 ttcatctcct tatggagtcc catactccaa acacagacct gagcagtgtt tctcccccac 11821 agactggttc aggcagaccc tgctgaagaa gcccaagaag aggcccggct ccctgacata 11881 cctgacactg cattatctca gttaactttc agcaactaag acaggtccac aagtccacag 11941 tcaaagccgt gtccctgact ccagagtgtg ggttctgaat cacgaagctc tccgctcctc 12001 agcaactctg agcagtagcc tcttccccat ttagcgacaa tctaggattt cttggggcca 12061 aacagatgcc agtcctccgt accccttcct tcctgtatac gtagcccttc ctaatctaag 12121 tccacctccc ctcagtgctg aaagtgggct ttgggactga tggatccttg ctagcataac 12181 gtagctctgc ctgcagactc ccggtggttg actagtcagc tctagtggga agttctgctt 12241 aaggtgggct gggctggggg taccagatat caaagggcct ggagtagtgc aaggccattt 12301 ctcttaacca ggctggtgga acactctcac ataaggattc cagagttctg acacgtccaa 12361 aacctttacc tttagagggc acttttaggc aagtcccaaa agataaacaa aaatagcaga 12421 gtgctgggca cagtggctca cgcctgtaat cccagcactt tgggaggctg aggcgggcag 12481 atcatgaggt cagaagttca agaccagcct gaccaacatg gtgaaacccc gtctctacta 12541 aaaatacaaa aattagccag gtgtggtggt gcatgcctgt aatcccagct actcaggagg 12601 ctgaggcagg agaatcgctt gaacctggga ggcagaagtt gcagtgagcc aagatcgcac 12661 cactgtactc cagcctgggt gagagtgaga ctctgcctca aaaaaaaaaa aaaaaaatag 12721 tggagcaaca ggtctctgag aataagatgt ttcccagtgc agggaggtgg gctgcagtct 12781 gtctgtcctc cctgtgaggt ggggctcctc cctgtgtggg cagtgagagg gcacctggta 12841 acacacaggc ctgagcagtg tttctccccc acagactggt tcaggcagac cctgctgaag 12901 aagcccaaga agaggcccaa ctccccagaa agcacctcca gcgatgcttc acagcctacc 12961 tcacaggaca gcccactacc cccaagcctc agctcagtca cgtctcccag cctgccaccc 13021 acacatgcga gtgacagtgg cagtagtcgc tggagcaaag actatgacgt ctgcgtgtgc 13081 cacagtgagg aagacctggt ggccgcccag gacctggtct cctacttgga aggcagcact 13141 gccagcctgc gctgcttcct gcaactccgg gatgcaaccc caggcggcgc tatagtgtcc 13201 gagctgtgcc aggcactgag cagtagtcac tgccgggtgc tgctcatcac gccgggcttc 13261 cttcaggacc cctggtgcaa gtaccagatg ctgcaggccc tgaccgaggc tccaggggcc 13321 gagggctgca ccatccccct gctgtcgggc ctcagcagag ctgcctaccc acctgagctc 13381 cgattcatgt actacgtcga tggcaggggc cctgatggtg gctttcgtca agtcaaagaa 13441 gctgtcatgc gttgtaagct actacaggag ggagaagggg aacgggattc agctacagta 13501 tctgatctac tttgactttt aggagacagc cctgtagcct agtagttcaa agcgcagctt 13561 ctggaaaagg ctgtcggggt ttgtatcctg gctcctgcac ttattaaccc ataaaaagta 13621 acttggtcaa gttactcacc cgctctgtgc cttggtttcc tcactgacca acaggtttcc 13681 attgctatga aatgagaaca gtatatacac gaagggctca gaacatggcc tagcacatgt 13741 attcataaca ggcagcgcct agcacaaatc aggtcctcaa gttaatagct agtagtagta 13801 acagtaatag cattaggttt ctctgagatc aggctggaga tgtccatcaa gagctgggaa 13861 ggtgccagga gggacattgg tttagtaagg caaaatgatg caaaataata ggaaagaagt 13921 gcatataagt gtatctgggg agggccatgc tattgcagta ggtttggaag tgtaatagat 13981 aaaaagatag aagaggcagg acctgttggg gaaaacagat gctgggtttg ggaggtgtga 14041 caacgctgtg attggtctct ttcagatctg cagacactca gttgacactt gttatatcat 14101 gggaccccgg aaattggagt gaagctagaa acagaaaacc catgcagggc ctcggattcc 14161 cacaaatgtg acaagaggta tagggagtga gtcgcagcgc tttgctcgtg accctgggat 14221 cagagcaccc atcaggcttc cattactgtg ggctccctaa gaagaccatg gagagcttgg 14281 ggactccccc aggaaggccg tgaagctggg gattccccct aggaaagcca tgaggaagct 14341 ggggactccc caagaaggcc atgaggaagc cagaaattgg aggtggtagg aagtggtact 14401 gatcaatgat ggccagcagg actcatctcc tgcctaactg gacaggaagc ctggcaccca 14461 cttctgtctt cccctggaac tgggcactgg cgtacactgg tatccctcct aaagaagtga 14521 ctcacctgac tgatcagcaa gaagcctaga ttgcaggcct caccatggat ggtcttccta 14581 gttgcctggg gaaaccctgg aatgggcatc aggagaaagc aacaagaatc cagtccttca 14641 cactcacact actctgttcc tcttcccaga gacatcgatt cacttcaaag agctgtaggg 14701 aagatgcagt cagcactgca ctgtattttt tatttattgc ctaggtgcca ttaaagacac 14761 aaacctagaa gcctagaggc cattctgaat atgggggtgg ggtggtggag ggagcaagtg 14821 aagagatggg aatccagggc tcagggttca acgccttcac ctgagatcac aagcccatgg 14881 atgctgtgac atctgggagc ttcatcagtg gtctggctaa agctgatact ttcacagtca 14941 ccatcttcac ctttggactg ggaagaatca ccatttttct tctggcagat gactgtattc 15001 cttataggac aggcaaggtt tcattcatct gttctcagta agtttgttgt tgaactgaaa 15061 tgaatttcat tatttcctcc aatgtgtact tttgtgcccc cctctcactt ctccctatca 15121 tgacccctct tttgctgaaa aaaattttta ttattttttc tatctctagt tctagaaaga 15181 gaaaatttat tttttaaatt ataaactatt ttgccaggcg ccatggctca cacctgtaat 15241 ctcagcactt tgggaggccg aggcaggtgg atcacctgag gtcaggagtt caagactagc 15301 ctggccaata tggtgaaacc ctgtctctac taaaaaaaca aaaaaaatca gctgggtgtg 15361 gtggcggggg cctgtagtct caactactcg ggaggttgag gcaggagaat tgcttgaacc 15421 tgggaggtgg agattgcagt gagctgaaat cacgccactg cactcgagcc tgggcaactg 15481 agcgagactc tgtctcaaaa aaaaaaggcc aggcatggtg gctcatgcct gtaatcctag 15541 tactttggga ggctgaggtg ggcagaatac aaggtcaaga gatcaagacc atcctggcca 15601 acatggtgaa accccatctc tactaaaaat acaaaaatta gctgggtgtg gtggcgtggg 15661 cctgtagtcc cagctactcg ggaggctgag gcaggagaat tgcttgaacc tgggaggcag 15721 aagttgcagt gagccgatat tgcaccaccg cactccagcc tgggtgacag agtgagactc 15781 catctcaaaa aaaagaaaaa aaaattattt tattatgcac aaaaggatta acaaataata 15841 tgtccactca tgtgcctacc acccagttta agaagcaaaa ccttatcatc ccttatagtg 15901 gtccctttgt gccctgaatt gcagtctccc cttcccccac cagaaataac cagcattttg 15961 aattttgaac ttcttgcttt tagcttttct ctatacattt actacatatg tatgcacctc 16021 caccagcata ctgtgtagtt ttacatggtt ttatatttta tgtaaacagc gttacagcgt 16081 ttgtattctg cagattcctt tccttgttca ccaaatgtga gatttatcca tgcggatgga 16141 tgacatgcca gttattaata atacactttc atcccacgat gtaaatatgc caccatttag 16201 ttacacattc ttctccaaat gggtatttgg tgttcctagg tttttgctat taaaaacaat 16261 gagcctctga acttttttgt acattttcac aagcaagatt ttctaggatt tagcctagaa 16321 aatcctgctg gggctgggtg tggtggctca tgcctgtaat cctaacactt tgggaggccg 16381 aggcgagcgc atcacttgag gccaggagtt tgagaccagc ctggccaaca tagtgaaacc 16441 ctgtctttac taaaaataca aaaattagcc aggcatggtg gtgcacgcct gtaatcccag 16501 ctacttggga ggctgaggca ggagaattgc ttgagcctgg gaggcagagg ttgcagtgag 16561 ctgagatatc gcaccactgc actctagcct gggtgacaga gcgagactcc atctcaaaaa 16621 aaaaaaaaaa aagaatatac atactatttt tctagaagat gccacagttt cttccaaatt 16681 ggctgtacca atttaagttc ctacaatttg tgtttaagag ttcccacttt ttcatgttct 16741 tgctaacgtt cagagttatc atatttttaa atgtttgcta atctggtgga tgaaaactgg 16801 taaactattg ttattttttt tccttttcat catttttatg aaaaaaaaaa tcaagcatat 16861 actgaaagga agaagtttga tgaatcccta tgtgcctgtc agctagcttc aacaattacc 16921 aactctgagc tactctttta tcaataatac cctactcata tctctcactc cccacaagat 16981 catttgaagc aaacctcaga aatcacttta ttcctaaata tttaagtatg catctctaac 17041 ttattaaaat ttttttggtt ttgttttttg tttttctgag acggaatttc actcttgttg 17101 cccaggctgg agtgcaatgg cgcaatcttg gctcactgca acctctgtct cccaggttca 17161 agtgattctc ctgcctaagt ctgggattac aggcatgcac caccacaccc ggctaatttt 17221 tgtattttta gtagagatgg ggtttcacca tattggccag gctagtcttg aacttctgac 17281 ttcaggtgat ccacctgcct cggcctccca aagtgctggg attacaggcg tgaagcacca 17341 cgcccagcct gaaataatat tttacctttt actttgtgct ttttgtgttt tactcaggaa 17401 gtcctcccct acatctgttt tcttctgtat ttcttttcat atttaggtct ttaatccacc 17461 tggatttttt gtttgggttt ttgttgttct ttagtcaaag atccaattct tttttctatt 17521 taaataacca tcattgactg actagtccat ccttacccca cccctactga ttatgatgtc 17581 actgctgtca catattgtca tacgtggggg gctgttactg ggttctccag tctcctccct 17641 ttactttatc tgtttgtgta tccctgtgct ggtgccacac tgcctcgttc actgatgttt 17701 ttaataagcc tgcaccattt gtatgtcaat tcttcctgct cttcttatcc atcaaaaatc 17761 actttaactt ttcttgttcc tttactcttc catataaatt gtttattcaa ccatcaggtt 17821 ccaggaaaaa gcctgttagt attttcattg gacttacatg gaatttgtag attttgaaaa 17881 aacagatatt tttatgagtc ttcctattca taaaaatagt atgtctccat ttacttatgt 17941 ctttaagtgt atttcagtaa agctttctat cttttccaca ttggtcagct cctcttttta 18001 ttagaattat tccctagcat ttcatatttt ctgttgctgt tgtaaagggt aattttacat 18061 ttttatctat tactgatata aagaattgta atttatttca catattgatc tagtattaag 18121 cagcatgctg aattacttaa ttctatatga ctataaactt tgcagggact tgctgttgcc 18181 caggctggag tgcagtggcg tgatcatggc tcaccactgc ctcgacctcc tgggcccaag 18241 caatgattct cctatctcag ccctctgagt agctgggacc acaggcctgt gccaccactc 18301 ctgactaatt tttctgtact ttttgtagag atggggtttt gccatgttgc ccaggctagt 18361 cttgaactct tgggttcaag ccatctgcct gcctggtctt cccaaagagc tgggatgaca 18421 ggtgtgagcc accacacctg tcttgttgaa ttttctataa acagtcatac aatttgcaaa 18481 agaaaacaaa aactttagtt ccttgtgtgg ttcctaaggc ctccaataaa acaaagtgac 18541 aatagcagcc atccttgtct cattccttag aaggaatgct tcacacattt ctccactaaa 18601 tgtgtgcgtt gtaggttttc tgatacataa ttttttcttt tttttttttt tttagtcttg 18661 ctctgtcgcc caggctggag tgcagtggcg caaccttggc tcactgcaac ctttgcctcc 18721 caggttcaag cgattctcct gcctcagcct cccaagtagc tgggactaca ggtgcgtgtc 18781 accacaccca gataattttt tgtattttta gtagcgatag ggtttcaccg tgttagccag 18841 gagggtctcg atctcctgac ctcacgatcc acccacctcg ggctcccaaa gtgctggaat 18901 tacaggcatg agccactgca cccagccttt ttttaattat tatttgaaga atttaagatt 18961 ggaattaatt gctccttgaa tgtttggtag actcatctgt aataccattt gagcctagaa 19021 tattctggtt tttttgagac ggagtcttgc cctattgccc aggccggagt gcagtgggat 19081 tacacgcgtg agccaccatg cctggccaga atattcttta ttgtaaaatt taaagctgta 19141 atttcaatgt cttgaagagt tatagatcta attagatttt ccatttctcc tggagtcaat 19201 ttggtacaaa cagtcaataa agactacaag accagtttaa gtagattttt cagtttgagt 19261 gtcctggatc atgtacacaa tcatgaatgt gaagtctgtc tgcatgaaga atcatctgtg 19321 gttataaatt cttaggaggt tttttccttc ttccctctgg aacaacggtt gaagcaggca 19381 agtttcctaa tcaccttctc tcctttagta gggcagcatt tttctttttt ataaatagtt 19441 ggcctggcca ggcatggtgg ctcacgccta taatcctagc actttgggag gccaaggcga 19501 gcagatcacc cgaggtcagg agttcgagac cagcctgacc aacgtggcga aactccgtct 19561 ctactaaaaa tacaaaaaaa ttagctatgc gtggtggtgg gtgcctgtaa tcccagctac 19621 tcaggaggct gatgcatgag aatcgcttga atccaggcag cggaggttgc agtgagctga 19681 gatcgcgcca ctgtactcca gcctgggcga cagagtgaga ctccgtatcc aaaaaaaaaa 19741 aaaaaaaaaa aaaattgttg gccccttcat tgagctagtg gaccttcagg gttcttagct 19801 ctatagaaag ttctgtatct taattcctct ttacataagc tcaggtcttg tctcttgtcc 19861 cttgaatcgg gtcctagacg tctagagatc agcaatggcc cttaaaatag cttccacctt 19921 aaaaatcccc ttaccactct atagattcaa actcccacat catttttggt tcctgcaaat 19981 tttacttttt tgagagctca gcaacgtaac taaaagaatg ttttaaattt tacatccaga 20041 atgttcgggt attttgtagc tgacttgttt tcagtttagt ctgttataat ccctgaaatg 20101 gaactgggaa gtatccaatc cttctttaga ctaaaaaaga aaagatttgg gaggtttttt 20161 tttttttttt tttttgagac agagtctcgc tctgtcactc aggctggagc acagtggtgc 20221 aatcttggct cattacaacc tccgcctcca ggttcaagcc attctcctgc ctcagcctcc 20281 cgagtagctg gaattatagg tgcctgctgc cacactcagc taatttttgt atttttaata 20341 gagatggggt ttcgccatgt tagccaggct agtctcaaac tcctgacctc aagtgatcca 20401 cccgccttgg cctcccaaag tgctgggatt acaggcgtga gccaccgcac cttgcgtggg 20461 agaaatttta agatttctga aaaacaattg aacagggctt tataataaat gagtaagcta 20521 atacagcatt gtctagtaga acttcctttg ataatgaaaa tgttctccat ctgtgctcat 20581 acgatagcca caagtggata tcaagcactt gcaaagtggc tagtgtaact gaggaaatga 20641 attttaacta ctaccataaa gattcctttc acactgaggt ctgg //