LOCUS AF386492 14544 bp DNA linear PRI 17-OCT-2003 DEFINITION Homo sapiens serine-cysteine proteinase inhibitor clade E member 1 (SERPINE1) gene, complete cds. ACCESSION AF386492 VERSION AF386492.2 GI:14488407 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 14544) AUTHORS Rieder,M.J., Carrington,D.P., Chung,M.-W., Lee,K.L., Poel,C.L., Yi,Q. and Nickerson,D.A. TITLE Direct Submission JOURNAL Submitted (29-MAY-2001) Molecular Biotechnology, University of Washington, 1705 NE Pacific, Seattle, WA 98195, USA REFERENCE 2 (bases 1 to 14544) AUTHORS Rieder,M.J., Carrington,D.P., Chung,M.-W., Lee,K.L., Poel,C.L., Yi,Q. and Nickerson,D.A. TITLE Direct Submission JOURNAL Submitted (19-JUN-2001) Molecular Biotechnology, University of Washington, 1705 NE Pacific, Seattle, WA 98195, USA REMARK Sequence update by submitter COMMENT On Jun 19, 2001 this sequence version replaced gi:14326587. To cite this work please use: SeattleSNPs. NHLBI Program for Genomic Applications, UW-FHCRC, Seattle, WA (URL: http://pga.mbt.washington.edu). FEATURES Location/Qualifiers source 1..14544 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" repeat_region 2..492 /rpt_family="MER1A" /rpt_type=dispersed variation 100 /frequency="0.01" /replace="T" variation 186 /frequency="0.03" /replace="T" variation 412 /frequency="0.02" /replace="T" variation 664 /frequency="0.37" /replace="A" variation 837 /frequency="0.35" /replace="-" variation 1002 /frequency="0.01" /replace="A" variation 1337..1338 /frequency="0.97" /replace="-" variation 1502 /frequency="0.01" /replace="T" gene 1581..13451 /gene="SERPINE1" mRNA join(1581..1654,2803..3074,4831..5064,6291..6485, 8115..8313,9912..10012,10133..10219,11418..11501, 11821..13451) /gene="SERPINE1" /product="serine-cysteine proteinase inhibitor clade E member 1" variation 1587 /gene="SERPINE1" /frequency="0.01" /replace="T" variation 1746 /gene="SERPINE1" /frequency="0.04" /replace="A" variation 1872 /gene="SERPINE1" /frequency="0.01" /replace="T" repeat_region 1975..2384 /rpt_family="AluJb" /rpt_type=dispersed variation 2035 /gene="SERPINE1" /frequency="0.01" /replace="C" variation 2037 /gene="SERPINE1" /frequency="0.06" /replace="T" variation 2188 /gene="SERPINE1" /frequency="0.01" /replace="A" variation 2262 /gene="SERPINE1" /frequency="0.01" /replace="A" variation 2362 /gene="SERPINE1" /frequency="0.06" /replace="-" variation 2380 /gene="SERPINE1" /frequency="0.01" /replace="T" variation 2627 /gene="SERPINE1" /frequency="0.01" /replace="A" variation 2714..2716 /gene="SERPINE1" /frequency="0.03" /replace="-" variation 2753 /gene="SERPINE1" /frequency="0.01" /replace="A" CDS join(2804..3074,4831..5064,6291..6485,8115..8313, 9912..10012,10133..10219,11418..11501,11821..11858) /gene="SERPINE1" /note="serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1" /codon_start=1 /product="serine-cysteine proteinase inhibitor clade E member 1" /protein_id="AAK60338.1" /db_xref="GI:14326588" /translation="MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQ QVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLY KELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIIN DWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGS TVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNI LSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSD QEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGT VLFMGQVMEP" variation 2846 /gene="SERPINE1" /frequency="0.05" /replace="A" variation 2852 /gene="SERPINE1" /frequency="0.07" /replace="A" variation 2877 /gene="SERPINE1" /frequency="0.01" /replace="C" variation 3268 /gene="SERPINE1" /frequency="0.02" /replace="T" variation 3302 /gene="SERPINE1" /frequency="0.02" /replace="T" repeat_region 3354..3658 /rpt_family="AluY" /rpt_type=dispersed variation 3373..3374 /gene="SERPINE1" /frequency="0.03" /replace="-" variation 3404 /gene="SERPINE1" /frequency="0.02" /replace="C" variation 3404 /gene="SERPINE1" /frequency="0.02" /replace="G" variation 3408 /gene="SERPINE1" /frequency="0.01" /replace="A" variation 3433 /gene="SERPINE1" /frequency="0.03" /replace="T" variation 3434 /gene="SERPINE1" /frequency="0.03" /replace="G" variation 3448 /gene="SERPINE1" /frequency="0.02" /replace="C" variation 3451..3452 /gene="SERPINE1" /frequency="0.05" /replace="-" variation 3508 /gene="SERPINE1" /frequency="0.02" /replace="G" variation 3512 /gene="SERPINE1" /frequency="0.01" /replace="A" variation 3567 /gene="SERPINE1" /frequency="0.01" /replace="C" misc_feature 3630..4544 /gene="SERPINE1" /note="Region not scanned for variation" repeat_region 3719..4024 /rpt_family="AluSx" /rpt_type=dispersed repeat_region 4129..4440 /rpt_family="AluJo" /rpt_type=dispersed repeat_region 4459..4568 /rpt_family="AluSp" /rpt_type=dispersed variation 4588 /gene="SERPINE1" /frequency="0.17" /replace="T" variation 5137 /gene="SERPINE1" /frequency="0.02" /replace="A" repeat_region 5145..5444 /rpt_family="AluJo" /rpt_type=dispersed variation 5262 /gene="SERPINE1" /frequency="0.02" /replace="C" variation 5278 /gene="SERPINE1" /frequency="0.04" /replace="-" variation 5404 /gene="SERPINE1" /frequency="0.20" /replace="G" repeat_region 5532..5827 /rpt_family="AluSx" /rpt_type=dispersed variation 5596..5601 /gene="SERPINE1" /frequency="0.01" /replace="-" variation 5645 /gene="SERPINE1" /frequency="0.27" /replace="T" variation 5686 /gene="SERPINE1" /frequency="0.17" /replace="A" variation 5708 /gene="SERPINE1" /frequency="0.01" /replace="A" variation 5725 /gene="SERPINE1" /frequency="0.01" /replace="G" variation 5834 /gene="SERPINE1" /frequency="0.03" /replace="A" variation 5878 /gene="SERPINE1" /frequency="0.24" /replace="G" repeat_region 5936..6245 /rpt_family="AluSg" /rpt_type=dispersed variation 5984 /gene="SERPINE1" /frequency="0.15" /replace="A" variation 6411 /gene="SERPINE1" /frequency="0.01" /replace="A" variation 6433 /gene="SERPINE1" /frequency="0.01" /replace="T" variation 6753 /gene="SERPINE1" /frequency="0.01" /replace="-" variation 6821 /gene="SERPINE1" /frequency="0.07" /replace="T" repeat_region 6854..7162 /rpt_family="AluSq" /rpt_type=dispersed variation 7121 /gene="SERPINE1" /frequency="0.41" /replace="G" repeat_region 7238..7427 /rpt_family="AluJo" /rpt_type=dispersed variation 7343 /gene="SERPINE1" /frequency="0.29" /replace="G" variation 7356 /gene="SERPINE1" /frequency="0.08" /replace="-" variation 7365 /gene="SERPINE1" /frequency="0.12" /replace="T" variation 7389 /gene="SERPINE1" /frequency="0.06" /replace="T" repeat_region 7428..7736 /rpt_family="AluSx" /rpt_type=dispersed variation 7429 /gene="SERPINE1" /frequency="0.03" /replace="C" variation 7437 /gene="SERPINE1" /frequency="0.40" /replace="T" variation 7722 /gene="SERPINE1" /frequency="0.01" /replace="G" variation 7729..7732 /gene="SERPINE1" /frequency="0.86" /replace="-" repeat_region 7737..7842 /rpt_family="AluJo" /rpt_type=dispersed variation 7770 /gene="SERPINE1" /frequency="0.07" /replace="T" variation 7771 /gene="SERPINE1" /frequency="0.13" /replace="A" variation 8070 /gene="SERPINE1" /frequency="0.40" /replace="A" variation 8092 /gene="SERPINE1" /frequency="0.01" /replace="A" variation 8178 /gene="SERPINE1" /frequency="0.01" /replace="A" variation 8406 /gene="SERPINE1" /frequency="0.40" /replace="C" variation 8511 /gene="SERPINE1" /frequency="0.01" /replace="A" repeat_region 9324..9624 /rpt_family="AluSx" /rpt_type=dispersed variation 9463 /gene="SERPINE1" /frequency="0.40" /replace="G" variation 9466 /gene="SERPINE1" /frequency="0.40" /replace="T" variation 9532 /gene="SERPINE1" /frequency="0.01" /replace="C" variation 9538 /gene="SERPINE1" /frequency="0.01" /replace="C" variation 9759 /gene="SERPINE1" /frequency="0.08" /replace="G" variation 10327 /gene="SERPINE1" /frequency="0.08" /replace="T" variation 10381 /gene="SERPINE1" /frequency="0.17" /replace="T" variation 10461 /gene="SERPINE1" /frequency="0.08" /replace="G" repeat_region 10512..10787 /rpt_family="AluSx" /rpt_type=dispersed misc_feature 10750..11170 /gene="SERPINE1" /note="Region not scanned for variation" repeat_region 11058..11349 /rpt_family="AluJo" /rpt_type=dispersed variation 11312 /gene="SERPINE1" /frequency="0.16" /replace="A" variation 11981 /gene="SERPINE1" /frequency="0.01" /replace="C" variation 12025 /gene="SERPINE1" /frequency="0.01" /replace="T" variation 12163 /gene="SERPINE1" /frequency="0.01" /replace="A" variation 12219 /gene="SERPINE1" /frequency="0.39" /replace="C" variation 12580 /gene="SERPINE1" /frequency="0.39" /replace="G" variation 12603 /gene="SERPINE1" /frequency="0.02" /replace="A" variation 12750 /gene="SERPINE1" /frequency="0.13" /replace="A" variation 12847..12854 /gene="SERPINE1" /frequency="0.11" /replace="-" variation 13053 /gene="SERPINE1" /frequency="0.02" /replace="T" variation 13140 /gene="SERPINE1" /frequency="0.99" /replace="-" variation 13226 /gene="SERPINE1" /frequency="0.02" /replace="C" repeat_region 13230..13333 /rpt_family="FLAM_C" /rpt_type=dispersed variation 13317 /gene="SERPINE1" /frequency="0.03" /replace="T" variation 13605 /frequency="0.23" /replace="A" variation 13651 /frequency="0.01" /replace="-" repeat_region 13745..14057 /rpt_family="AluSx" /rpt_type=dispersed variation 13856 /frequency="0.02" /replace="A" variation 13889 /frequency="0.39" /replace="C" variation 13985 /frequency="0.08" /replace="T" variation 14137 /frequency="0.13" /replace="A" repeat_region 14440..14544 /rpt_family="AluJo" /rpt_type=dispersed variation 14440 /frequency="0.26" /replace="A" ORIGIN 1 cgtactggtc catagcctgt taggaaccag gctgcataac aggaggtgag tggcaggtga 61 gtgaaatttc atctgtagtt acagccactc ctcatcactc gcattaccac cagagctcca 121 ctccctgtca gatcagcggc ggcattagat tctcatagga gctcgaaccc tattctaaac 181 tgttcatgtg agggatctag gttgcaagct ccctatgaga atctaatgcc tgatgatctg 241 tcacggtctc ccatcacccc tagatgggac catctagttg caggaaaaca agctcagggc 301 tcccactgat tctacacgat ggtgaattgt ggaattattt cattatatat attacaatgt 361 aataataata gaaataaagc acacaataaa tgtaatgtgc ttgaatcatc ccgaaaccat 421 cccaccctgg tctgtgaaaa aattgtcttc catgaaacca gtccctggtg ccaaaaacgt 481 tgaggaccac tgctccacag aatctatcgg tcactcttcc tcccctcacc cccttgccct 541 aaaagcacac cctgcaaacc tgccatgaat tgacactctg tttctatccc ttttcccctt 601 gtgtctgtgt ctggaggaag aggataaagg acaagctgcc ccaagtccta gcgggcagct 661 cgaggaagtg aaacttacac gttggtctcc tgtttcctta ccaagctttt accatggtaa 721 cccctggtcc cgttcagcca ccaccacccc acccagcaca cctccaacct cagccagaca 781 aggttgttga cacaagagag ccctcagggg cacagagaga gtctggacac gtgggggagt 841 cagccgtgta tcatcggagg cggccgggca catggcaggg atgagggaaa gaccaagagt 901 cctctgttgg gcccaagtcc tagacagaca aaacctagac aatcacgtgg ctggctgcat 961 gccctgtggc tgttgggctg ggcccaggag gagggagggg cgctctttcc tggaggtggt 1021 ccagagcacc gggtggacag ccctggggga aaacttccac gttttgatgg aggttatctt 1081 tgataactcc acagtgacct ggttcgccaa aggaaaagca ggcaacgtga gctgtttttt 1141 ttttctccaa gctgaacact aggggtccta ggctttttgg gtcacccggc atggcagaca 1201 gtcaacctgg caggacatcc gggagagaca gacacaggca gagggcagaa aggtcaaggg 1261 aggttctcag gccaaggcta ttggggtttg ctcaattgtt cctgaatgct cttacacacg 1321 tacacacaca gagcagcaca cacacacaca cacacacatg cctcagcaag tcccagagag 1381 ggaggtgtcg agggggaccc gctggctgtt cagacggact cccagagcca gtgagtgggt 1441 ggggctggaa catgagttca tctatttcct gcccacatct ggtataaaag gaggcagtgg 1501 cccacagagg agcacagctg tgtttggctg cagggccaag agcgctgtca agaagaccca 1561 cacgcccccc tccagcagct gaattcctgc agctcagcag ccgccgccag agcaggacga 1621 accgccaatc gcaaggcacc tctgagaact tcaggtagga gaaaagcaaa ctccctccaa 1681 cctcttactt cgggcttaag gcagagaact cgcctcccca gaatctcctc cctccatgat 1741 cccccgctat tcctctattt tcttttcctc ggacctgcag ccttgggtcg accctgccct 1801 aggggtgact gcaggagagc agggaggatg gtcaggcgtc accaacaacc ccatcaccca 1861 gtaacaagaa ccttgactct ctcagtccct ctgcatcaag acacttaccc atttcccacc 1921 tcatgcctgc taacttgaat gaaacaatcg ctgggaaagc attaagagaa ttaaggctgg 1981 gcactgtggc tcatgcctgt aatcccagca ctttgtgagg ctgaggcagg cagataactt 2041 gagcccagga gtttgagacc agcctgggca acatggcaaa accctgctct cccaaaaaaa 2101 tacaaaaatt agctgggcgt gctggtgtgc ctgtattccc agctacttgg gaggctgagg 2161 tgggaggatt gcttcagctg gggaggcgga ggctgcaggg agccaagact gagccattgc 2221 acccagcctg ggtgacagag caagaccctg tctctaaaaa tgaatgaaag gaaggaagaa 2281 agagagagaa agagagagag gaaagaagga aggaagtaaa gaagaaagaa agaaagaaag 2341 aggaaagagg aagaaagaaa gaaaagaaag aaaagaaaag aaagcaaatt taaagcttat 2401 gcaaatcaaa gatgttgtga taattgataa ttgagtctgg gctaaattcc ccctgggctg 2461 caaaggcaga gagtggtaat gacttctcac ctgcttttct tctaaggctt ttttacggga 2521 cacagaggga agggagatgg actggattcc aagattccca cagggcaaga tgggcgaaga 2581 ctccctgcca ctgcccgggg ataagtcagt ctgagtgaga cggagtggga tgggcttaga 2641 acctgaacat gtcatggtct cttcctgcac cttgccctag tgttcactta ccacctgctt 2701 gcaggaaaca agaagagcag ggcccacagc tggccagctc ccctcccctc ccgcctgtct 2761 tccagaacga ttccttcacc agccctcttt ccattgctct aggatgcaga tgtctccagc 2821 cctcacctgc ctagtcctgg gcctggccct tgtctttggt gaagggtctg ctgtgcacca 2881 tcccccatcc tacgtggccc acctggcctc agacttcggg gtgagggtgt ttcagcaggt 2941 ggcgcaggcc tccaaggacc gcaacgtggt tttctcaccc tatggggtgg cctcggtgtt 3001 ggccatgctc cagctgacaa caggaggaga aacccagcag cagattcaag cagctatggg 3061 attcaagatt gatggtgagc cacgggacac caggggaggt gggtggcatg cagaacagac 3121 ctaccagaag ccaaggaaag gctggctctg gcttagccga gccaagcccc atacagctgt 3181 gctgcagggg ccaccccatc ttcttcccac tacactccaa gtcactggac ccttgaatct 3241 ccaagggtgt ctgaccagta gatttaccgc ttattcacca ccgtgtgatc ttaacctcgt 3301 taagtttgcc catctacaaa atgaggatta tttgctgtcc taaagaattc atgagccggg 3361 cgcggtggct caaacgcctg taatcccagc actttgggag gccaaggcgg gcggatcatg 3421 aggtcaggag atcaagacca tcctggctaa cacagtgaaa ctccatctct actaaaaata 3481 caaaaaaaat tagccaggcg tggtggcagg cgcctgtagt cccagctact cgggaggctg 3541 aggcaggaga atggcatgaa cccaggaggc agagcttgca gtgagctgag atcgtgccac 3601 tgcactccag cctgggcgac agagagagac tccgtctcaa aaaaaaaaat taaaagaatt 3661 catggaatta cacttgtgaa atacttagca tagccatcac tataggaaaa aaatctaagg 3721 ccaggcacag tgcctcatgc ctgtaatctc agcactttcg gagtttgagg caggaggatc 3781 acccaaggct aggagttcaa ggccagcctg ggcaatacgg tgaaaccccg tctctaataa 3841 aaatataaaa attagtctga tgaggtggtg cacctgtaat cccagctact caggaagctg 3901 agacacaaga atcactttaa cccgggaggt ggaggtggca gtgagctgag atcacaccat 3961 tgcactccag cctgggtgac agagtgagac ctgtcaaaaa aaagaaaaga aagagagaga 4021 gagagagaag agagagaaag aaagaagaag aaagaaagaa agagagagag agaaagaaag 4081 aaagaaacaa agaaacaaag aaagaaagga aaagaaaaaa aaaactaagg ccaggcaagg 4141 tggcttatga ctgtaatttc agcactttgg aagattgagg caggaggatc acttgaggcc 4201 agaagttcga gacaagactg agcaacaggg agacccctgc ctctacaaaa aaatttacaa 4261 attagccaga tgtggtgaca catacctgta gtcccaacta ctcaggaggc tgaggtggga 4321 ggatggcttg agcccaggag ctggaggctg cagtgagcta tgattgtacc actgcacttc 4381 agcctgggca acaaagggaa gccctgtctg aaaaaaaaaa aaaaagaaaa agaagaagaa 4441 agaaaatatt tagggttcat ccaggaggca gaggttgcag taagctgaca tcgcgccatt 4501 gcactccagc ctgggagaca agagcaaaac tccaactcaa aaaaaaaaaa aaaaaaaaaa 4561 caggaagaaa atatttaggg ttcataactt aagaacagag aaaaatattc tagcccaaag 4621 aaagggttgg gatctgagac ttttgaagaa aggaaggaga tacagaaaag agatttcatc 4681 ctggaatgaa atctccctcc agagagccct gggaaagcac ggtagccccc atccatcaga 4741 gtggagcccc ttgtggggga agtgggctcg gctgggaacc ctcaattcag cataagcctc 4801 acatgtcctc tcctctctgt cccggtgcag acaagggcat ggcccccgcc ctccggcatc 4861 tgtacaagga gctcatgggg ccatggaaca aggatgagat cagcaccaca gacgcgatct 4921 tcgtccagcg ggatctgaag ctggtccagg gcttcatgcc ccacttcttc aggctgttcc 4981 ggagcacggt caagcaagtg gacttttcag aggtggagag agccagattc atcatcaatg 5041 actgggtgaa gacacacaca aaaggtgagc aggcagggaa aggaaaccca tttcctgggc 5101 ctcaagagaa agggaatttg gaaataaatc cacatatccc agttgggtgc agtagttcac 5161 acctgtaatc ccagcccaac actttgggag gtctaggcga gaggaaggct tgaggcctgg 5221 agtttgagac cagcctggcc aacataacaa gacctcatct cttcaaaaaa tttaaaaacc 5281 agccgggcat ggtggtgcac acctgtagtc ccagctactt gggaggctga ggtgggagga 5341 tcacttgagt ccagcagttc aaggctgcag tgagctatgt ttgcaccacc acactccagc 5401 ctgagtcaca gaacaagacc tcatctctaa aaaacaaaca aaaaccaaat ccacatatcc 5461 taaaaaatgc tccttttcag cattctcttc tctatggaca aagggctgga tgctttaaga 5521 accaaatctt aggctgggca cggtggctca cgcctctaat cctagcactt tgagaggcca 5581 aggcgggcag attgcctgag cacaggagtt cgagaccagc ctggccaaca tggtgaaacc 5641 ctgtctctgt caaaaataca aaaaattagc caggtgtgtt ggcgcgtgcc tataatccca 5701 gctgctcggg aggatgaggt tcaaagaatc acttgaaccc gggaggcaga ggctgcagtg 5761 agctgagatc atgccactgc actccagcct gggtgacaga gcaagacttt gtctccaaaa 5821 aaaggaacta gacgggttca tttaaacccc tgactgcagc cctttgacat acatccaatt 5881 gaggactggg gactccggga aacatctaaa aggcttaaaa actttgtcta acttcagccg 5941 ggcatggtgg ctcacacctg taatcccagc actttgggag gctgaggcag gtggatcaca 6001 aggtcaggag tttgagacga gcctgaccaa catggtgaaa ccccgtctct actaaaaata 6061 caaaaattag ccaggcatgg tggcaggcgc ctgtaatccc agctattcgg gaggctgagg 6121 caggagaatt gcttgaaccc cggagacaga ggttgcagcg agccgagatc gcgccactgc 6181 actccagcct ggcaatagag tgagactcca tctcaaaaca acaacaacaa caacaacaac 6241 aacaaaatcg tctaacttcc tgatcttcct gatcattgat tttcccatag gtatgatcag 6301 caacttgctt gggaaaggag ccgtggacca gctgacacgg ctggtgctgg tgaatgccct 6361 ctacttcaac ggccagtgga agactccctt ccccgactcc agcacccacc gccgcctctt 6421 ccacaaatca gacggcagca ctgtctctgt gcccatgatg gctcagacca acaagttcaa 6481 ctatagtaag tccaagagcc ccttccccac agcccacagc aactgcatct cattcctggg 6541 gtctcccaag gaatacccaa aatgtcaccc tctgagggag gaagaccaca gggaatgctc 6601 ccctttaagg gaggagagac cctagaatat actccagctt tgacaaagat ttcccaagca 6661 ggagacatca ggataatggg aacagaagac aggaggttta tcccatgaag gatgaagaag 6721 ctgaaatcca gagattccct cagggccaca tttgtccacc tgactccagg gtctcatctt 6781 cgtgtgttgc tagtgtgatt acctggggat gagaaatcct gctgggggag ttgaggttaa 6841 gaggatgagg actccaggtg ctgtggctca cgcctgtaat cccagcactt tgggaggcca 6901 aggcaggtgg atcaggagtt tgaggtcagg agtttgagac cagcctggcc aacatggtga 6961 aaccctgtct ctactaaaaa tgcaaaaatt agccaggtgt ggtggcaggc gcctgtaatc 7021 ccagctactc gggaggctga ggcaggagaa tcacttgagc ccgggaggtg gaggttgcag 7081 tgagccgaac gaaattgagc cacttcaccc cagcctgggc aaaagagtga aattccattc 7141 aaaaaaaaaa aaaaaaaaaa aaggatgagg actgggatga actggtggct gggtgtgggg 7201 aaaatggaag tgaaggaagg ccaaaagaga cagagaaggc ctggcgcggc gactcacgcc 7261 tataatccca gcactttggg aggctgagaa gggggattgc ttgaggccag aagttgaata 7321 ccagtctggg cagcatagca agaccctgcc tctacaaaaa aaaaattttt tttaattagc 7381 caggcttggt gacatgcatc tgtagtctac tcaagaagct gaggtgaggc caggcacggt 7441 ggctcacgcc tgtattccca gcactttggg aggtcaaggc gggtggatga cctgaggtca 7501 ggagttcaag accagcctgg ccaacatggt gaaaccccat ctgtataaaa atacaaaaat 7561 tagctgggca tgatagcagg tgcctgtaat tccagctact caggaggctg aggtgggaga 7621 atctattgaa cccgggaggg ggaggttgca gtgagccgag atcatgccat tgcactccag 7681 cctgggcgac agagtgagac tccttctcaa aacaaacaaa caaacaaaca aacaaaatac 7741 agaagctgag gcgggaggaa catttgaacc ggattcggag gctgcagtga gctatgattg 7801 caccactgcg ctccagtctg tgtgacagtg agaccctgtc tcttacacac acacacacac 7861 acacacacac acatgcacac acacagagag agagaaatta gaagatactg aattggcaga 7921 agagaaggga aatagaaatt aaaatactga ataggggagc agtgaacagg ggatacccaa 7981 aagccaagag cgagagagag cctggcttcc agaaatagtg gagaagccag gagaactagg 8041 tgaaaaccca gtgctgggtt gccatcagcg agagctggag ccatttccaa cgaaccatct 8101 tgtcgtcttc acagctgagt tcaccacgcc cgatggccat tactacgaca tcctggaact 8161 gccctaccac ggggacaccc tcagcatgtt cattgctgcc ccttatgaaa aagaggtgcc 8221 tctctctgcc ctcaccaaca ttctgagtgc ccagctcatc agccactgga aaggcaacat 8281 gaccaggctg ccccgcctcc tggttctgcc caagtaagcc accccgctat ctccccgacc 8341 taccaacccc tctctcctgg ctccctaaag tcaccgcccc caggttgaat ttcccagatc 8401 tgtgatgctt gcaggacatg catgtgtggg aggctgatgg gaaactgtgg cctgggtttg 8461 attatgagtc ttgcaatcat ccctccccct gtttctgctg gagggcaggg gacagctctt 8521 cctgaccaca cccccacatt gactatcccc agaataccca gcaaaagccc ccaaaaggag 8581 agtcagagaa atgagggagg tgggggccca atcagtccac atctacttag ggtcgcccca 8641 tcagcacttc catccccaac cctttcaagt caacatccaa acaaaagaaa tcacttccaa 8701 ggacggagca gctcaaagcg cagcttctag ctggggttcc aagaaagcag atttttcgaa 8761 atccttctgc agaaggaagc aaagagattt tttgaaatct ttctgcagaa ggagaaggct 8821 ggagctgggg aactccagaa ttatagggaa gcctcccacc acgctcatcc caaatttccg 8881 gatgctataa tgccaggctt ggggaaagag gagaatttag ttggttagct ggtgcgtgct 8941 ctcacttgca tcctctctct tcctcttttt tttttttctc ctctctctct ggctcataaa 9001 aatggaggta attagttgtg ccctggtgag aagcagagag tgcacaaagg ccccctgctt 9061 gagtcctctt cagggttagc tctcagaaac acaatctgca gaacagattt ttgttccaac 9121 atccttgcag gagaatttgc ccttagcttc ccccacccca gccaggctga ataaaattat 9181 gctgaaacta ctgtcttatt tgaggaaagt aattagtcat aggtgggagg gggtggggag 9241 attgcagaag aatgttcatg aatattagga ttttcagctc taagggggga ctttgtaaac 9301 agctttagaa gaagaaccag gccggctggg tgtggtggct catgcctgta atctcagcat 9361 ttggggaggc caaggcgggc ggatcacttg aggtcaggag tttgagacca gcctggccaa 9421 catggtgaaa ccctgtctct attaaaaata caaaaattag ccagccgtgg tagcgagcgc 9481 ctatgatccc agctactccg gaggctgagg ccagagaatc acatgaacct gggaggtgga 9541 ggctgcagtg agccgagatc acgccactgc actccagcct gggggacaga gcaagaatct 9601 gtttcaaaaa aaaaaaaaga aaaataggaa ggaaggaagg aaaggaaagg aaagaagaga 9661 gagagaaaga aagagagaga gagagagaga aagaaagaaa gaaagaaaga aagaaagaaa 9721 gaaagaaaga aagaaagaaa gaaaaagaaa ggaaagaaag aacgaacgaa ccaggcctcc 9781 ctctccaacc ttcacctccg tccctattct ggccacttga ttcgggggac acctggtagg 9841 ggatggggaa aggtgggagc tgccagccag aggggacccc ggcttgagca gcctcttgct 9901 gctatctgca ggttctccct ggagactgaa gtcgacctca ggaagcccct agagaacctg 9961 ggaatgaccg acatgttcag acagtttcag gctgacttca cgagtctttc aggtaagaag 10021 actttccttt gcattttctc accccagtgg actgcggggg cccctaagag gaaaaaggaa 10081 cctctccttg agagcggcag ctgatctaat cctgtatcca catctgtttc agaccaagag 10141 cctctccacg tcgcgcaggc gctgcagaaa gtgaagatcg aggtgaacga gagtggcacg 10201 gtggcctcct catccacagg tgagtctggc tcaggtgagg ctccacgggt gtcgcctcca 10261 tcgcccttca ggataactgg tccccagacc cggaaaggac cccgcagccc tctcggcaca 10321 gagcagctct gtctgtgctc agccatcacc cactccccac ctgtttctca gcctggaaaa 10381 cgggcttggg accatggaac cctgtttcct cgcctgatgg ctcctaagtt ccctgactgt 10441 gaaaaggcct cctaaagaaa aacccaagtt gttcccacag tgggaagtaa acttaagaaa 10501 catgcttatc aggctgggca tggtggctcc cacctgtaat cccagcgctt tgggggacca 10561 aggcaggtgg atcacttgag gtcaggaatt cgagaccagc ctgggcaaca tggcaaaacc 10621 ctatctctac taaaaataca aaaattaggc aggcgtggtg gcatgtgcct gtagtcccag 10681 ctacttggga ggctgaggca ggagaatcac ttgaatccag gaggcagagg ttgcagtgag 10741 ccgagatcac gctgctgcac tccagcctgg gcaatagagc atgactctga agaaaagaaa 10801 gaaagaaaga gagagagaga gaaaagaaag aaagaaagaa agaaagaaag aaagaaagaa 10861 agaaagaaag aaagaaagaa agagaaagaa agagaagaaa agaaaagaaa gagcttatca 10921 ataagccctt aaaggattta gataaatgtg tgtaagggaa gagctgatcc attgctacca 10981 agctcctgga ggaaaccagg tctcagagga tgtccctaaa cttttaaggt tcatattcag 11041 gaaaacaaac aacttccagc tgggcttagt ggctcacacc tgtaatccca gcactttggg 11101 aggccgaggc aggaggatcg cttgagccca ggaatttgag accagcctgg gcaatataat 11161 gagactgtgc tctacaaaaa ttagaaaaaa attagccagg catggtggca tgcacctgta 11221 gccccagtta cttgggagac tgaggtggga ggatcacttg agcccatgag ttcaaggctg 11281 cagtgagcca tgaaggtgcc actgcactcc cgcctgggcg acagagggag accctgtctc 11341 taagaaaaac ggcgggggtg ggggtggtgc cagtgccagc atccctctgt tctaagacat 11401 tgtcccttct cttgcagctg tcatagtctc agcccgcatg gcccccgagg agatcatcat 11461 ggacagaccc ttcctctttg tggtccggca caaccccaca ggtgagcctg gaacccatca 11521 cgttccacat cctcccaccc attctttctc tcaggaacta gtcccgacag atgcagacat 11581 ccctctatcc ctgagagggc tctgggcagg gaaccataac cctaccctgc ttcctgtccc 11641 aagaggaggc taccttctat cacccacaga cagtgccggg tccccgctct gtgactcagg 11701 cagctgcgac tccagacagc tcactcatct gcctagatct cagtccttcc acccacatcc 11761 agcctgatga gctgtcccac tccttctgct tctcaacccc catggttctt ccaccctcag 11821 gaacagtcct tttcatgggc caagtgatgg aaccctgacc ctggggaaag acgccttcat 11881 ctgggacaaa actggagatg catcgggaaa gaagaaactc cgaagaaaag aattttagtg 11941 ttaatgactc tttctgaagg aagagaagac atttgccttt tgttaaaaga tggtaaacca 12001 gatctgtctc caagaccttg gcctctcctt ggaggacctt taggtcaaac tccctagtct 12061 ccacctgaga ccctgggaga gaagtttgaa gcacaactcc cttaaggtct ccaaaccaga 12121 cggtgacgcc tgcgggacca tctggggcac ctgcttccac ccgtctctct gcccactcgg 12181 gtctgcagac ctggttccca ctgaggccct ttgcaggatg gaactacggg gcttacagga 12241 gcttttgtgt gcctggtaga aactatttct gttccagtca cattgccatc actcttgtac 12301 tgcctgccac cgcggaggag gctggtgaca ggccaaaggc cagtggaaga aacacccttt 12361 catctcagag tccactgtgg cactggccac ccctccccag tacaggggtg ctgcaggtgg 12421 cagagtgaat gtcccccatc atgtggccca actctcctgg cctggccatc tccctcccca 12481 gaaacagtgt gcatgggtta ttttggagtg taggtgactt gtttactcat tgaagcagat 12541 ttctgcttcc ttttattttt ataggaatag aggaagaaat gtcagatgcg tgcccagctc 12601 ttcacccccc aatctcttgg tggggagggg tgtacctaaa tatttatcat atccttgccc 12661 ttgagtgctt gttagagaga aagagaacta ctaaggaaaa taatattatt taaactcgct 12721 cctagtgttt ctttgtggtc tgtgtcaccg tatctcagga agtccagcca cttgactggc 12781 acacacccct ccggacatcc agcgtgacgg agcccacact gccaccttgt ggccgcctga 12841 gaccctcgcg ccccccgcgc cccccgcgcc cctctttttc cccttgatgg aaattgacca 12901 tacaatttca tcctccttca ggggatcaaa aggacggagt ggggggacag agactcagat 12961 gaggacagag tggtttccaa tgtgttcaat agatttagga gcagaaatgc aaggggctgc 13021 atgacctacc aggacagaac tttccccaat tacagggtga ctcacagccg cattggtgac 13081 tcacttcaat gtgtcatttc cggctgctgt gtgtgagcag tggacacgtg aggggggggg 13141 tgggtgagag agacaggcag ctcggattca actaccttag ataatatttc tgaaaaccta 13201 ccagccagag ggtagggcac aaagatggat gtaatgcact ttgggaggcc aaggcgggag 13261 gattgcttga gcccaggagt tcaagaccag cctgggcaac ataccaagac ccccgtctct 13321 ttaaaaatat atatatttta aatatactta aatatatatt tctaatatct ttaaatatat 13381 atatatattt taaagaccaa tttatgggag aattgcacac agatgtgaaa tgaatgtaat 13441 ctaatagaag cctaatcagc ccaccatgtt ctccactgaa aaatcctctt tctttggggt 13501 ttttctttct ttcttttttg attttgcact ggacggtgac gtcagccatg tacaggatcc 13561 acaggggtgg tgtcaaatgc tattgaaatt gtgttgaatt gtatgctttt tcacttttga 13621 taaataaaca tgtaaaaatg tttcaaaaaa ataataaaat aaataaatac gaagaatatg 13681 tcaggacagt cactgccttc accttctcca tttcacaccg gtggtacaag aaatcagaag 13741 cctaggccag gtgtggtggt tcatgcctgt aatcccagca ctttgggaag ccgaggtggg 13801 tggatcacct aaggtcagga gtttgagacc agcctggaca acatggtgaa accccgtctc 13861 tactaaaaat acaaaaatta gccgggcgtg gtggctggcg cctgtaatcc cagctactcg 13921 ggaggctgag gcaggagaat cacttgaagc caggaggcag aggttgcagt gagctgagat 13981 tgcaccactg aactccaggc tgggtggcag agcgagactc cctctcaaaa aacaacaact 14041 acaaagacaa caacaaaccc agaatcaaaa tcctgttggt ccatagacct catgggtgga 14101 agagaccttc ctacatccag gttggcccaa catgggggag tccatgaaat ggtcacctca 14161 gctctgccac aagccccaag gataagttga ttctgcccct gggaatcatc ctcaaaaagg 14221 aaaaaaatgt tcccctgcca taaactttcc acttatgcag atgggcctgc tcgtaagtca 14281 ctgtcactgt gggttcccaa ctctgttcat gacacttcct tccagcacca aatgcttccc 14341 acccctctac tcccactccc cattcttcaa acccagctca agttccagtt cctccaccta 14401 ggacttccca tggatccagc caatatcact ctcaggtccg gcgcagtggc ccacgcctgt 14461 aatctcagca ctttgggagg ccggggcagg aagattgctt gaggccagga gtttcagacc 14521 agcctggaca acatagtgag actc //