LOCUS AY137079 17447 bp DNA linear PRI 05-AUG-2002 DEFINITION Homo sapiens interleukin 1, beta (IL1B) gene, complete cds. ACCESSION AY137079 VERSION AY137079.1 GI:22122009 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 17447) AUTHORS Rieder,M.J., Armel,T.Z., Carrington,D.P., Ozuna,M., Kuldanek,S.A., Rajkumar,N.R., Toth,E.J., Yi,Q. and Nickerson,D.A. TITLE Direct Submission JOURNAL Submitted (29-JUL-2002) Genome Sciences, University of Washington, 1705 NE Pacific, Seattle, WA 98195, USA COMMENT To cite this work please use: SeattleSNPs. NHLBI HL66682 Program for Genomic Applications, UW-FHCRC, Seattle, WA (URL: http://pga.gs.washington.edu). FEATURES Location/Qualifiers source 1..17447 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" repeat_region 37..332 /rpt_family="Alu" /rpt_type=dispersed variation 302 /frequency="0.13" /replace="g" variation 500..503 /frequency="0.96" /replace="" variation 794 /frequency="0.40" /replace="t" variation 855 /frequency="0.01" /replace="g" variation 1274 /frequency="0.40" /replace="c" gene 1306..8330 /gene="IL1B" mRNA join(1306..1376,1840..1901,2467..2518,4515..4716, 5264..5428,6668..6798,7517..8330) /gene="IL1B" /product="interleukin 1, beta" variation 1455..1456 /gene="IL1B" /frequency="0.99" /replace="" CDS join(1855..1901,2467..2518,4515..4716,5264..5428, 6668..6798,7517..7729) /gene="IL1B" /codon_start=1 /product="interleukin 1, beta" /protein_id="AAM88883.1" /db_xref="GI:22122010" /translation="MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPL DGGIQLRISDHHYSKGFRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEP IFFDTWDNEAYVHDAPVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSM SFVQGEESNDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFN KIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQFVSS" variation 1913 /gene="IL1B" /frequency="0.04" /replace="t" variation 1942 /gene="IL1B" /frequency="0.01" /replace="g" variation 1964 /gene="IL1B" /frequency="0.01" /replace="c" variation 2070 /gene="IL1B" /frequency="0.01" /replace="g" variation 2143 /gene="IL1B" /frequency="0.32" /replace="c" variation 2701 /gene="IL1B" /frequency="0.02" /replace="t" variation 2712 /gene="IL1B" /frequency="0.04" /replace="t" variation 2714 /gene="IL1B" /frequency="0.01" /replace="a" variation 2766 /gene="IL1B" /frequency="0.14" /replace="" variation 2824 /gene="IL1B" /frequency="0.01" /replace="c" repeat_region 3007..3101 /rpt_family="MIR" /rpt_type=dispersed variation 3298 /gene="IL1B" /frequency="0.44" /replace="a" variation 3535 /gene="IL1B" /frequency="0.01" /replace="a" repeat_region 3924..4027 /rpt_family="MIR" /rpt_type=dispersed variation 4006 /gene="IL1B" /frequency="0.15" /replace="a" repeat_region 4067..4378 /rpt_family="Alu" /rpt_type=dispersed variation 4068 /gene="IL1B" /frequency="0.02" /replace="c" variation 4070..4074 /gene="IL1B" /frequency="0.99" /replace="" variation 4246 /gene="IL1B" /frequency="0.99" /replace="" variation 4325 /gene="IL1B" /frequency="0.12" /replace="t" variation 4392 /gene="IL1B" /frequency="0.21" /replace="c" variation 4505 /gene="IL1B" /frequency="0.01" /replace="t" repeat_region 5043..5106 /rpt_family="MIR" /rpt_type=dispersed variation 5200 /gene="IL1B" /frequency="0.34" /replace="a" variation 5277 /gene="IL1B" /frequency="0.18" /replace="t" variation 5916 /gene="IL1B" /frequency="0.03" /replace="t" variation 6293 /gene="IL1B" /frequency="0.01" /replace="c" variation 6334 /gene="IL1B" /frequency="0.21" /replace="a" variation 6873 /gene="IL1B" /frequency="0.01" /replace="t" variation 6874 /gene="IL1B" /frequency="0.21" /replace="a" variation 6909..6910 /gene="IL1B" /frequency="0.23" /replace="" variation 7114 /gene="IL1B" /frequency="0.15" /replace="t" variation 7135 /gene="IL1B" /frequency="0.03" /replace="t" variation 7154 /gene="IL1B" /frequency="0.01" /replace="g" variation 7275 /gene="IL1B" /frequency="0.01" /replace="g" variation 7277 /gene="IL1B" /frequency="0.01" /replace="c" variation 8234 /gene="IL1B" /frequency="0.21" /replace="c" variation 8449 /frequency="0.03" /replace="c" variation 8546 /frequency="0.22" /replace="t" repeat_region 8611..8699 /rpt_family="L2" /rpt_type=dispersed repeat_region 8847..9176 /rpt_family="Alu" /rpt_type=dispersed variation 9077 /frequency="0.02" /replace="c" variation 9198 /frequency="0.12" /replace="t" repeat_region 9288..9899 /rpt_family="L1" /rpt_type=dispersed repeat_region 9900..10093 /rpt_family="MaLR" /rpt_type=dispersed repeat_region 10119..10321 /rpt_family="MaLR" /rpt_type=dispersed repeat_region 10322..10437 /rpt_family="L1" /rpt_type=dispersed repeat_region 10597..10743 /rpt_family="Alu" /rpt_type=dispersed repeat_region 10744..11127 /rpt_family="MaLR" /rpt_type=dispersed repeat_region 11128..11283 /rpt_family="Alu" /rpt_type=dispersed repeat_region 11787..12003 /rpt_family="L1" /rpt_type=dispersed variation 11787 /frequency="0.24" /replace="t" variation 12764 /frequency="0.03" /replace="t" variation 12885 /frequency="0.31" /replace="a" variation 13501 /frequency="0.01" /replace="g" repeat_region 13647..13743 /rpt_family="MIR" /rpt_type=dispersed repeat_region 13752..14175 /rpt_family="L2" /rpt_type=dispersed variation 14140 /frequency="0.01" /replace="a" repeat_region 14176..14483 /rpt_family="Alu" /rpt_type=dispersed variation 14179 /frequency="0.01" /replace="t" variation 14226 /frequency="0.01" /replace="a" variation 14365 /frequency="0.03" /replace="a" variation 14374 /frequency="0.01" /replace="a" repeat_region 14484..14916 /rpt_family="L2" /rpt_type=dispersed variation 14674 /frequency="0.03" /replace="a" repeat_region 14917..15017 /rpt_family="Alu" /rpt_type=dispersed variation 15036 /frequency="0.21" /replace="a" repeat_region 15038..15218 /rpt_family="Alu" /rpt_type=dispersed variation 15041 /frequency="0.01" /replace="t" variation 15079 /frequency="0.12" /replace="g" repeat_region 15219..15871 /rpt_family="L2" /rpt_type=dispersed variation 15235 /frequency="0.26" /replace="g" variation 15409 /frequency="0.02" /replace="c" variation 15573 /frequency="0.01" /replace="t" variation 15801 /frequency="0.01" /replace="g" repeat_region 15928..16021 /rpt_family="L2" /rpt_type=dispersed variation 16837 /frequency="0.06" /replace="t" variation 16996..17004 /frequency="0.01" /replace="" repeat_region 17337..17443 /rpt_family="ERV1" /rpt_type=dispersed ORIGIN 1 gcaaggtttc aactcagtgc tataagaagt gttacaggct ggacacggtg gctcacgcct 61 gtaatcccaa cactttggga ggccgaggcg ggcagatcac aaggtcagga gatcgagacc 121 atcctggcta acatggtgaa accctgtctc tactaaaaat acaaaaaatt agccgggcgt 181 ggcggcaggt gcctgtagtc ccagctgctg gggaggctga ggcaggagaa tggtgtgaac 241 ccgggaggcg gaacttgcag ggggccgaga tcgtgccact gcactccagc ctgggcgaca 301 gagtgagact ctgtctcaaa aaaaaaaaaa aagtgttatg atgcagacct gtcaaagagg 361 caaaggaggg tgttcctaca ctccaggcac tgttcataac ctggactctc attcattcta 421 caaatggagg gctcccctgg gcagtaccct ggagcaggca ctttgctggt gtctcggtta 481 aagagaaact gataactctt ggttggtatt accaagagat agagtctcag atggatattc 541 ttacagaaac aatattccac ttttcagagt tcaccaaaaa atcattttag gcagagctca 601 tctggcattg atctggttca tccatgagat tggctagggt aacagcacct ggtcttgcag 661 ggttgtgtga gcttatctcc agggttgccc caactccgtc aggagcctga accctgcata 721 ccgtatgttc tctgccccag ccaagaaagg tcaattttct cctcagaggc tcctgcaatt 781 gacagagagc tcccgaggca gagaacagca cccaaggtag agacccacac cctcaataca 841 gacagggagg gctattggcc cttcattgta cccatttatc catctgtaag tgggaagatt 901 cctaaactta agtacaaaga agtgaatgaa gaaaagtatg tgcatgtata aatctgtgtg 961 tcttccactt tgtcccacat atactaaatt taaacattct tctaacgtgg gaaaatccag 1021 tattttaatg tggacatcaa ctgcacaacg attgtcagga aaacaatgca tatttgcatg 1081 gtgatacatt tgcaaaatgt gtcatagttt gctactcctt gcccttccat gaaccagaga 1141 attatctcag tttattagtc ccctccccta agaagcttcc accaatactc ttttcccctt 1201 tcctttaact tgattgtgaa atcaggtatt caacagagaa atttctcagc ctcctacttc 1261 tgcttttgaa agctataaaa acagcgaggg agaaactggc agataccaaa cctcttcgag 1321 gcacaaggca caacaggctg ctctgggatt ctcttcagcc aatcttcatt gctcaagtat 1381 gactttaatc ttccttacaa ctaggtgcta agggagtctc tctgtctctc tgcctctttg 1441 tgtgtatgca tattctctct ctctctctct ttctttctct gtctctccct ctccttccct 1501 ctctgcctcc ctctctcagc tttttgcaaa aatgccaggt gtaatataat gcttatgact 1561 cgggaaatat tctgggaatg gatactgctt atctaacagc tgacacccta aaggttagtg 1621 tcaaagcctc tgctccagct ctcctagcca atacattgct agttggggtt tggtttagca 1681 aatgcttttc tctagaccca aaggacttct ctttcacaca ttcattcatt tactcagaga 1741 tcatttcttt gcatgactgc catgcactgg atgctgagag aaatcacaca tgaacgtagc 1801 cgtcatgggg aagtcactca ttttctcctt tttacacagg tgtctgaagc agccatggca 1861 gaagtacctg agctcgccag tgaaatgatg gcttattaca ggtcagtgga gacgctgaga 1921 ccagtaacat gagcaggtct cctctttcaa gagtagagtg ttatctgtgc ttggagacca 1981 gatttttccc ctaaattgcc tctttcagtg gcaaacaggg tgccaagtaa atctgattta 2041 aagactactt tcccattaca agtccctcca gccttgggac ctggaggcta tccagatgtg 2101 ttgttgcaag ggcttcctgc agaggcaaat ggggagaaaa gattccaagc ccacaataca 2161 aggaatccct ttgcaaagtg tggcttggag ggagagggag agctcagatt ttagctgact 2221 ctgctgggct agaggttagg cctcaagatc caacagggag cacccagggt gcccacctgc 2281 caggcctaga atctgccttc tggactgttc tgcgcatatc actgtgaaac ttgccaggtg 2341 tttcaggcag ctttgagagg caggctgttt gcagtttctt atgaacagtc aagtcttgta 2401 cacagggaag gaaaaataaa cctgtttaga agacataatt gagacatgtc cctgttttta 2461 ttacagtggc aatgaggatg acttgttctt tgaagctgat ggccctaaac agatgaaggt 2521 aagactatgg gtttaactcc caacccaagg aagggctcta acacagggaa agctcaaaga 2581 agggagttct gggccacttt gatgccatgg tattttgttt tagaaagact ttaacctctt 2641 ccagtgagac acaggctgca ccacttgctg acctggccac ttggtcatca tatcaccaca 2701 gtcactcact aacgttggtg gtggtggcca cacttggtgg tgacagggga ggagtagtga 2761 taatgtttcc catttcatag taggaagaca accaagtctt caacataaat ttgattatcc 2821 ttttaagaga tggattcagc ctatgccaat cacttgagtt aaactctgaa accaagagat 2881 gatcttgaga actaacatat gtctacccct tttgagtaga atagtttttt gctacctggg 2941 gtgaagctta taacaacaag acatagatga tataaacaaa aagatgaatt gagacttgaa 3001 agaaaaccat tcacttgctg tttgaccttg acaagtcatt ttacccgctt tggacctcat 3061 ctgaaaaata aagggctgag ctggatgatc tctgagattc cagcatcctg caacctccag 3121 ttctgaaata ttttcagttg tagctaaggg catttgggca gcaaatggtc atttttcaga 3181 ctcatcctta caaagagcca tgttatattc ctgctgtccc ttctgtttta tatgatgctc 3241 agtagccttc ctaggtggcc cagccatcag cctagctagg tcagttgtgc aggttgggag 3301 gcagccactt ttctctggct ttattttatt ccagtttgtg atagcctccc ctagcctcat 3361 aatccagtcc tcaatcttgt taaaaacata tttctttaga agttttaaga ctggcataac 3421 ttgttggctg cagctgtggg aggagcccat tggcttgtct gcctggcctt tgcccccatt 3481 gcctcttcca gcagcttggc tctgctccag gcaggaaatt ctctcctgct caactttctt 3541 ttgtgcactt acaggtctct ttaactgtct ttcaagcctt tgaaccatta tcatgcctta 3601 aggcaacctc agtgaagcct taatacggag cttctctgaa taagaggaaa gtggtaacat 3661 ttcacaaaaa gtactctcac aggatttgca gaatgcctat gagacagtgt tatgaaaaag 3721 gaaaaaaaag aacagtgtag aaaaattgaa tacttgctga gtgagcatag gtgaatggaa 3781 aatgttatgg tcatctgcat gaaaaagcaa atcatagtgt gacagcatta gggatacaaa 3841 aagatataga gaaggtatac atgtatggtg taggtggggc atgtacaaaa aagatgaaca 3901 aagtagaaat gggatttatt ctaaaagaat agcctgtaag gtgtcagaaa gcccacattc 3961 tagtcttgag tctgcctcta acctgctgtg tgcccttgag tacaccctta acctccttga 4021 gcttcagaga gggataatct ttttatttta ttttatttta ttttgttttg ttttgttttg 4081 ttttgttttg ttttatgaga cagagtctca ctctgttgcc caggctggag tgcagtggta 4141 caatcttggc ttactgcatc ctccacctcc tgagttcaag cgattctcct tcctcagtct 4201 cctgaatagc taggattaca ggtgcacccc accacaccca gctaattttt tgtattttta 4261 gtagagaagg ggtttcgcca tgttggccag gctggttttg aagtcctgac ctaaatgatt 4321 catccacctc ggcttcccaa agtgctggga ttacaggcat gagccaccac gcctggccca 4381 gagagggatg atctttagaa gctcgggatt ctttcaagcc ctttcctcct ctctgagctt 4441 tctactctct gatgtcaaag catggttcct ggcaggacca cctcaccagg ctccctccct 4501 cgctctctcc gcagtgctcc ttccaggacc tggacctctg ccctctggat ggcggcatcc 4561 agctacgaat ctccgaccac cactacagca agggcttcag gcaggccgcg tcagttgttg 4621 tggccatgga caagctgagg aagatgctgg ttccctgccc acagaccttc caggagaatg 4681 acctgagcac cttctttccc ttcatctttg aagaaggtag ttagccaaga gcaggcagta 4741 gatctccact tgtgtcctct tggaagtcat caagccccag ccaactcaat tcccccagag 4801 ccaaagccct ttaaaggtag aaggcccagc ggggagacaa aacaaagaag gctggaaacc 4861 aaagcaatca tctctttagt ggaaactatt cttaaagaag atcttgatgg ctactgacat 4921 ttgcaactcc ctcactcttt ctcaggggcc tttcacttac attgtcacca gaggttcgta 4981 acctccctgt gggctagtgt tatgaccatc accattttac ctaagtagct ctgttgctcg 5041 gccacagtga gcagtaatag acctgaagct ggaacccatg tctaatagtg tcaggtccag 5101 tgttcttagc caccccactc ccagcttcat ccctactggt gttgtcatca gactttgacc 5161 gtatatgctc aggtgtcctc caagaaatca aattttgccg cctcgcctca cgaggcctgc 5221 ccttctgatt ttatacctaa acaacatgtg ctccacattt cagaacctat cttcttcgac 5281 acatgggata acgaggctta tgtgcacgat gcacctgtac gatcactgaa ctgcacgctc 5341 cgggactcac agcaaaaaag cttggtgatg tctggtccat atgaactgaa agctctccac 5401 ctccagggac aggatatgga gcaacaaggt aaatggaaac atcctggttt ccctgcctgg 5461 cctcctggca gcttgctaat tctccatgtt ttaaacaaag tagaaagtta atttaaggca 5521 aatgatcaac acaagtgaaa aaaaatatta aaaaggaata tacaaacttt ggtcctagaa 5581 atggcacatt tgattgcact ggccagtgca tttgttaaca ggagtgtgac cctgagaaat 5641 tagacggctc aagcactccc aggaccatgt ccacccaagt ctcttgggca tagtgcaatg 5701 tcaattcttc cacaatatgg ggtcatttga tggacatggc ctaactgcct gtgggttctc 5761 tcttcctgtt gttgaggctg aaacaagagt gctggagcga taatgtgtcc atccccctcc 5821 ccagtcttcc ccccttgccc caacatccgt cccacccaat gccaggtggt tccttgtagg 5881 gaaattttac cgcccagcag gaacttatat ctctccgctg taacgggcaa aagtttcaag 5941 tgcggtgaac ccatcattag ctgtggtgat ctgcctggca tcgtgccaca gtagccaaag 6001 cctctgcaca ggagtgtggg caactaaggc tgctgacttt gaaggacagc ctcactcagg 6061 gggaagctat ttgctctcag ccaggccaag aaaatcctgt ttctttggaa tcgggtagta 6121 agagtgatcc cagggcctcc aattgacact gctgtgactg aggaagatca aaatgagtgt 6181 ctctctttgg agccactttc ccagctcagc ctctcctctc ccagtttctt cccatgggct 6241 actctctgtt cctgaaacag ttctggtgcc tgatttctgg cagaagtaca gcttcacctc 6301 tttcctttcc ttccacattg atcaagttgt tccgctcctg tggatgggca cattgccagc 6361 cagtgacaca atggcttcct tccttccttc cttcagcatt taaaatgtag accctctttc 6421 attctccgtt cctactgcta tgaggctctg agaaaccctc aggcctttga ggggaaaccc 6481 taaatcaaca aaatgaccct gctattgtct gtgagaagtc aagttatcct gtgtcttagg 6541 ccaaggaacc tcactgtggg ttcccacaga ggctaccaaa ttacatgtat cctactcatg 6601 gggcctaggg gttggggtga ccctgcactg ctgtgtccct aaccacaaga cccccttctt 6661 tcttcagtgg tgttctccat gtcctttgta caaggagaag aaagtaatga caaaatacct 6721 gtggccttgg gcctcaagga aaagaatctg tacctgtcct gcgtgttgaa agatgataag 6781 cccactctac agctggaggt aagtgaatgc tatggaatga agcccttctc agcctcctgc 6841 taccacttat tcccagacaa ccaccttctc cccgccccca tccctaggaa aagctgggaa 6901 caggtctatt tgacaatttt gcattaatgt aaataaattt aacataattt ttaactgcgt 6961 gcaaccttca atcctgctgc agaaaattaa atcattttgc cgatgttatt atgtcctacc 7021 atagttacaa ccccaacaga ttatatattg ttagggctgc tctcatttga tagacacctt 7081 gggaaataga tgacttaaag ggtcccatta tcacgtccac tccactccca aaatcaccac 7141 cactatcacc tccagctttc tcagcaaaag cttcatttcc aagttgatgt cattctagga 7201 ccataaggaa aaatacaata aaaagcccct ggaaactagg tacttcaaga agctctagct 7261 taattttcac ccccccaaaa aaaaaaaatt ctcacctaca ttatgctcct cagcatttgg 7321 cactaagttt tagaaaagaa gaagggctct tttaataatc acacggaaag ttgggggccc 7381 agttacaact caggagtctg gctcctgatc atgtgacctg ctcgtcagtt tcctttctgg 7441 ccaacccaaa gaacatcttt cccatagcat ctttgtccct tgccccacaa aaattcttct 7501 ttctctttcg ctgcagagtg tagatcccaa aaattaccca aagaagaaga tggaaaagcg 7561 atttgtcttc aacaagatag aaatcaataa caagctggaa tttgagtctg cccagttccc 7621 caactggtac atcagcacct ctcaagcaga aaacatgccc gtcttcctgg gagggaccaa 7681 aggcggccag gatataactg acttcaccat gcaatttgtg tcttcctaaa gagagctgta 7741 cccagagagt cctgtgctga atgtggactc aatccctagg gctggcagaa agggaacaga 7801 aaggtttttg agtacggcta tagcctggac tttcctgttg tctacaccaa tgcccaactg 7861 cctgccttag ggtagtgcta agaggatctc ctgtccatca gccaggacag tcagctctct 7921 cctttcaggg ccaatcccca gcccttttgt tgagccaggc ctctctcacc tctcctactc 7981 acttaaagcc cgcctgacag aaaccacggc cacatttggt tctaagaaac cctctgtcat 8041 tcgctcccac attctgatga gcaaccgctt ccctatttat ttatttattt gtttgtttgt 8101 tttattcatt ggtctaattt attcaaaggg ggcaagaagt agcagtgtct gtaaaagagc 8161 ctagttttta atagctatgg aatcaattca atttggactg gtgtgctctc tttaaatcaa 8221 gtcctttaat taagactgaa aatatataag ctcagattat ttaaatggga atatttataa 8281 atgagcaaat atcatactgt tcaatggttc tgaaataaac ttcactgaag aaaaaaaaag 8341 ggtctttcct gatcattgac ttgtcttgga tttgacactg aacagtaaag acaaacaggg 8401 ctgtgagagt tcttggggga ctaaagccca ctcctcattg ctgagtgctg caaagtacct 8461 agaaatatcc ttggccaccg aagactatcc tcctcaccca tcccctttat ttctgttgtt 8521 caacagaagg atattcagtg cacatctgga acaggatcag ctgaagcact gcagggagtc 8581 aggactggta gtaacagcta ccagtgattt atctatcaat gcaccaaaca tctgttgagc 8641 aagcgctatg tactaggagc tgggagtaca gagatgagaa cagtcacaag tccctcctca 8701 gataggagag gcagctagtt ataagcagaa acaaggtaac atgacaagta gagtaagata 8761 aagaacaaga ggagtagcca ggaaggaggg aggagaacga cataagaatc aagcctaaag 8821 ggataaacag aagatttcca cacatgggct gggcatggtg gcttacgcct gtaatcccag 8881 cactttgggt ggcaggggca gaaagatcgc ttgagcccag gagttcaaga ccagcctggg 8941 caacatagtg agactcccat ctctacaaaa aataaataaa taaataaaac aatcagccag 9001 gcatgctggc atgcacctgt agtcctagct acttgggaag ctgacactgg aggattgctt 9061 gagcccagaa gttcaagact gcagtgagct gtgatcgcac cattgcactc cagcctgggt 9121 gacagagtga gaccctgtct ctaaaaaatg ttcccagata gaaaagaaaa gaaaaagccc 9181 tcaggtagag gaaccagcgt gaacaagagc atgggtgtat aagaatgaat gatgcaaaaa 9241 gtacactttc agaattgcgg gaatcaccag aagcaaagtc aaagcgcaaa acaagccaga 9301 ggaaaagtag ttgtaactca caccccagat aaagagataa cttgtttcac atgtaaagaa 9361 ctgcctcaaa acatttgaaa aaaaagaaca aaaatccagc aaaacaagag gcaagggatc 9421 ttaacagtct gttcacagaa aagaaaatac tatttgatct tgggcagagt aaaatgatgc 9481 ttaacattgt aataagaaag tcaaattaaa agcactttga gatactagta ttttcccatc 9541 agattgacaa aaatcaaaag tttaacaaca gaccttgttg gtcaaactgt cgggaaatcc 9601 ccactgttaa atattacgcg tgggactata aattgatatg acccttatag aacaaaattt 9661 gctaactatg aaaatcacaa gtgcacttcc cctttgatcc agcaatttca ctcctggaga 9721 tttatcccac agatggacat aacccatgtg aaatggaaaa tgatcaaaat tattcattgc 9781 acatcatttg taataggaaa aattggaagt aacccaagtg tctatcaaca agagactgcc 9841 taaatgaagt aaaggacata gaatactagg cagctataga aaagaatgag aaagcactct 9901 ggtattgttt ggttctgtgt cccagcccaa atctcatgtc aaattgtaat ccccgatgtt 9961 ggaggtgggg cctggtgtgg ggtgattgga tcatgggggt ggagttctta tgaatggttt 10021 agcactatcc ctttggtgct gttctcgtga cagagttccc acaagatctg gttgtttaaa 10081 agtatgtggc atcctttctc tctctctctc tctctctcag tcctgctcct gccatataag 10141 acatccactc ccgctttgtc ttctgcatga gtaaaagctt cctaaggcct ccccagaagc 10201 agatgctgcc atgcttcctg tggaacagcc tgcgaagctg tgagccaatt aaacctcttt 10261 tctttataaa ttatgcagtc tcaggtattt ccttatagca atgcaaggac tgactaatac 10321 atgctgtctg cacgaatatg aaatcctctc caaaacatgc tgatagctga aaaagaagaa 10381 aatgcagacc gtatttatga tatgctaact ctgatgtaac aaaagggagg ggaagaaggg 10441 caatacattc cactgtgctt gtatttgatt tttttttttg attctggaag atacataaga 10501 aatgaataaa gtagttgtca gaggctgagg aataagatat atagggacag gtgtgggagc 10561 aagacacttt tatgaacaca ttttacacag tttgggtttt ttttttttgg agacaaggtc 10621 tcgctgtcac ccaggctgga gagcagtggt acagtcatgg ctcactgcag ccttaaactc 10681 ccaggctcaa gcaatcctct tacctcagcc tcctgggtag ctgggaatac aaacatatgg 10741 cactatattc atccactctc acactgctat aaagaatgac ctgagactgg gtaatttatg 10801 aagaaaagag gtctaactga ttcacagttc tacaggctgt acaggaagca tagctgggag 10861 gcttcaggaa acttacaatc atggcggaag gcaaagggga aacacacacg tcttactatg 10921 gcggagcagg agagtgagag agtgaagggg gaggtgctac acactttcaa ataaccaggt 10981 cttgtgagaa ctcactcact atcatgagaa cagcaaggga gaacccaccc ccatgatcca 11041 atcacctccc accaggaccc tccctcaaca ttgaggatta aaattcaaca tgaggtttga 11101 gttgggtcac agagccaaac catatcagcc accatgccca actaattttt gtttttaaat 11161 ttttgtagat acagggtctc actatgttac ccaggctggt cttgaactcc tgggctgaag 11221 tgatcctccc gcctcggcct cctaaattgc taggattaca ggcataagca gccatgcctg 11281 gcctacagtt tgatttttga atcatgtaaa tatattattc agaaataaaa taataatttt 11341 taaatatttt atcccaaaaa aatgtatctg acttcttgtg gaaggacaac tgttgagttg 11401 agggagctgc cagtcttcgg cagctcactc tcaataccct ccttctttga agttctccaa 11461 gctagggcag aggctggcaa agcccctctc ctagctctgt ctgcttcata actgcagtgc 11521 aaaggatgac atggctgtcg gagcagacac ccaagtggca accattctat aagatggaac 11581 agagctggtg gcaggaaagc aggtggtctg ggaagaaagc agaggtgcct gtgagcttga 11641 gctgtcattt gaccctctat ccttgattta gtgacacaat tctgccagct ctctcagata 11701 caaaagggaa gacatgccag gaagaatgaa actgtgaagg catctcacct tgtgaggaag 11761 ccagattcca aatcatctct gtatgggtaa gtgggtatgg ccattttgga gagaaaattg 11821 gtagcgtcta gtttttttgg gttttttaaa catgttcttt ggctcagcaa ttccactact 11881 tgccatcttc cgtaaagaaa tttatggaca tctactgatg cgttgtttat aaatacttaa 11941 tgaaatcaac tagaaacaac ctacatatct gttgatagag gcaaggttaa ataaacaatg 12001 gtaagttaaa aagaaaggag atgctactga aatagaaaga tagccaagca aatcattgag 12061 agaaaaaggc aaattatgga acaagaacag agtgataaca tttacgtaaa acaaaacact 12121 gcacatcctc aatgcaaaac catgtgcttc taatggtata tagaggtaga gaggtctgga 12181 agggtattgg caagactgat aatagtggtt acttggagtg gaatagggca gaggagcgag 12241 tcatcaagag gaactttagc tttatttatg acatttgaat ttttaccaaa aaaaaaaatt 12301 tggtaaatgt gtttaacaaa ttttgtttta ttagattttt gttcttattt tttctagtgt 12361 tttgagggat ctctttagat gttaagcaaa tatattcgtg aatgactcgt atcatttttt 12421 taatcccctg cattaaaatg ttcaaaagcc ttggttccaa ttcctggatc tgagccaaag 12481 atcaaaattg accctccaga ccagaactga cctttctatt acaggtttag agccaagttc 12541 tctccctggg taacaactcc ctatttctct gtactatgtg cccttggcct ggacgaggga 12601 aatggtctac cactaaatgg aaagggtctg ataatttgag tggagaaagc tgagaatcct 12661 ccccacaccc aagcaagtac acaaatacaa ctggaagaag gcagtctttc tgaagggctg 12721 tgaagtcaac ttctctgcac ctgcagcagg taacacacca cacctccaca gctgctacca 12781 gctttccagg agagcctgtg tacctggaga ggagaaggca agtgcttccg aacttgactt 12841 gatgtcttag attctgcaat gcgtagtctg tagggacagg ctgtggctta tcctataggc 12901 ttgggctgga gtcagcaagc atctgggctg gcagaagata aaagatgcaa aggtggagga 12961 aagcatacgt ggtctggaag acagacttgg tgggtgggtg gctgctacaa caccctagtt 13021 agaggtagag gggtaagtca gtgtgtcttc tgcacaggcc tcttccccac ctcattcttc 13081 atttcccata cagccttgct gagttattca caaacatctg attcaactgg aagctgggtt 13141 gaggatgacc taaaggacta gtgtgatgcc tgcccagggg tgtgggccca tagtcagagt 13201 ccagagcctc ctctcagctt ttagcacatc tcacccacat cctgggtcct taattagcaa 13261 tatgaaagca agccaagtga caagattttg tccctgggaa gtccagaagc actccttttc 13321 tcatttgtat aagcataatg atttgcttac ataaataatc atgaaaattc aaatccctct 13381 cagaaatcag gtcataaaac catgaaatgc agcatgtggg caagaatcac agggaaaggt 13441 aggtcttgga gaggaaagga tggcagggag gaagaaagca gggtgccagg ggccctgggc 13501 tgctgtccaa gtcaggtggc tcaccgtctc tgagaacatt tcactttctg gtaaatgggg 13561 cagttggaga tagaagggtt gggtgaatgc caagagtgag cacagctgag gtcagtgctg 13621 tgcctgcagt ccaggcggga gtagaaatcc tgggcccatc ttacctccga cctcatttcc 13681 tcctctgtaa taatgtgggg gtgggggaaa gttctggtca tcagccctag cattccatgg 13741 ttcatttcct catcagtgat ggaaaatcac caagcaagag aacaggatgg agaataaccg 13801 gatgggtgca atcggaggtg ctatttcagg tgaggtggcc agggaaggcc ctctgaaagg 13861 gtggcttgag caggtggctg aatgtacaga agctgccaat catgaaagat ctggggtaca 13921 gcatgccaag cagaggaaat gcgagtgcaa aggccccgag attggatgtg ggcttagcac 13981 aaatgtggca tggcaagaag gccagtgtgg ctgaagcagc atgaacaatg ggtggagggg 14041 ctgagaggac agaggagcag gaaagagcca ggcttgggta ggagaggtgt caacttgata 14101 tatgatgcaa agcccttgga ggttcccaaa cacaaaagcg atgatctaat atatggtttt 14161 aaaaatgcca ctcttggccg ggcgcggtgg ctcacgcctg taatcccagc actttgggag 14221 gccgaggcgg gtggatcatg aggtcaggag atcgagacca tcctggctaa caaggtgaaa 14281 ccccgtctct actaaaaata caaaaaatta gccgggcgcg gtggcgggcg cctgtagtcc 14341 cagctactcg ggaggctgag gcaggagaat ggcgtgaacc cgggaggcgg agcttgcagt 14401 gagccgagat tgcgccactg cagtccgcag tccggcctgg gcgacagagc gagactccgt 14461 ctcaaaaaaa aaaaaaaaaa aaatgccact cttgctgtga aaaattgacc ctgggggaag 14521 gaggagtaga aatgtcaaaa gtggaagcag accactcagg aggtcagggc aatggactgt 14581 gcaggagaga ctgacatctt agactcgggc aataggagag aaggtggtga ggattatatt 14641 ctgggcataa aggcaacaga actagctgat ggcgtcaacg taggagatga gggaaagaaa 14701 gaaatcaaag ggcattcata ggtttgaggg ttgagtaact ggggatattt aacagaaatg 14761 gagaagtctg gggaaggggc aagtattgtg ggggcagggg tcaaaagttc tgtattttgg 14821 ccaagttaat taatatttga gatacctctt aggtgtccaa gtgaagatgt caaacagtca 14881 attgaataca aaatctgaat cttagcccag gatggtctca cacctgtaat cccagcactt 14941 tgggaggctg aggtgagagg atcacttgag gccaggagtt tgtgatcagc ctgggcaata 15001 gagcaagacc ctgtctccac acacacacac acacacaaaa agtcatccag gcatggtggc 15061 acatgcctgt agtcccagct actcaggaag ctgaggcagg aggatcactt gagcccatgg 15121 ttcaaggctg cagtgagcta taatcacatc actcaatact acactccagc ctggatgaca 15181 gagagagacc tcatttatta aaataaaatt taaaaaaatt aattaaaaat aaatccaaat 15241 ctttcctgag attcatattc aggagtaact gtcatgtaga aggcatataa tgccatgggt 15301 cacatgatac catctaatga atgccactgg aaaagagaga atagctaaaa actgagcact 15361 gggcacacca gcacagtgag gttggaagga agaaatggag ctaacaaagg agacaaaaga 15421 ggagtagcca gtgagaagag agaaacatct ggagagaaga gagagcagca aaaggtgggt 15481 gaaggagaat gtggtccacc aggcccaaca atgctgagca gttgagtaag tgaggacctg 15541 gccactgaat ttggcaagaa agaggatgtc agcggcccta gaacaaaagt gaagaagagc 15601 ttgaggacgg aagcctgaca ggagtgaact gaggagagaa tgaaaggtgg agacatggag 15661 ccaaggagca ctgagactcc cttgagtagt tttgctgtaa aataaaagtg agtgcagaga 15721 cggggcaggg ggacagagaa atgcaggggt agctggaggg agccacagaa tcaaaagagg 15781 gtttttgtgt ttaagatggt agttgtcaca tagcacatta gtaagttcat gtgaatcaca 15841 acgtaggtga gacagatcac taatgcagga gtcaaatcct tgcagagccc ccagaggagg 15901 tgatgaaggg aagtgatgga catcattcag atgcaagtag gttagcaatt cctggggtac 15961 aaataggagg tgactccttt ctgattgctc ctgttttctg aatgagatag cacataaagt 16021 ccactcagcc atgttagctg ttgaagtcct tgtggctgtc atgcctgtac agactgggct 16081 ctcctctcca gcatttcctc tcagactaag ctgagctgca ctagccgctg ccacatcctc 16141 ttggggccat cctctgccac actccacata ttgctgtggt ttgcttgcaa cccctggaag 16201 gtcctactgg ctgctcctag aagagtctgg gcggcatctc tcccttactc gttatcacat 16261 ggtgctgtaa gcagtggcca cacactttag ctggtgggat gggccatcac aggcagtaaa 16321 tgcgaaagac tgctcagatt ttaaagcacc catgaatcag tagaatgagt ttagaattgt 16381 agtcatcaac acacattaaa aaaaaaaaaa acaggcacta aaaaaattag ttgagtagga 16441 taaagcaata aaagatatta actacaaacc agataggagg tgcaaaattg tacctacata 16501 aatcagatgg aaaaagttga aagcagataa gataaaatag gtaagcatga catttaaaag 16561 gtattcatgg gacgtggtta caaaaccaac tcacaactaa aaagtcttag gacctctcgc 16621 tgacttagga gcctgatccc aactctgaga atgactcagt gtgttaccct gtggctagtg 16681 tagaccaatg atcctgtctc agagtcacta gccaacagcc catatcaagt acttgaaact 16741 ttgactcaga aacctcagtg tcagaacctt tgacctagga accacctgta gtggttaact 16801 gcaatttgca ccccttagtt cagggcttta caacaccggg ggcggggagg gggaaggcat 16861 agagctgatg acctaaagga aacccattgc agcaacgctt ttgtgttaag tttacaaata 16921 agtgttgttt tagaatcctc caggtaatgc ctttgttatt taatgtgtct gagacaattc 16981 tgcacattaa agaatataaa atattacctt gtaattccaa tttgaaatgt gtaattgaca 17041 ttagacttct attttaattt gaaatgtcta aaacaatgtg gttaagtttg taaaaggtgt 17101 gtgaattttg agtctgattt actacatttt tttttaattt tctttttttt tggagtttta 17161 gggattgctt agatggctag aaagatttta ttcatcagat ttttaagtct gccttggcag 17221 gcacttgcag tgtttgaaag aatcagatat atcaaatttg tagtttaaaa tatttaaggg 17281 aactcaatta actatgctag aaaagagagt taagtattta ggaggattta atatggtgtt 17341 aaagttgtga aaatcaaaat ggagacacta atgttaagaa aaccctgata aatggagcca 17401 gggaaggcca tgaagaaaga gttctcacac ttgtatccct gatcatg //