LOCUS AF536338 18446 bp DNA linear PRI 21-AUG-2002 DEFINITION Homo sapiens interleukin 1, alpha (IL1A) gene, complete cds. ACCESSION AF536338 VERSION AF536338.1 GI:22385323 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 18446) AUTHORS Rieder,M.J., Armel,T.Z., Carrington,D.P., Ozuna,M., Kuldanek,S.A., Rajkumar,N.R., Toth,E.J., Yi,Q. and Nickerson,D.A. TITLE Direct Submission JOURNAL Submitted (08-AUG-2002) Genome Sciences, University of Washington, 1705 NE Pacific, Seattle, WA 98195, USA COMMENT To cite this work please use: SeattleSNPs. NHLBI HL66682 Program for Genomic Applications, UW-FHCRC, Seattle, WA (URL: http://pga.gs.washington.edu). FEATURES Location/Qualifiers source 1..18446 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" repeat_region 2..293 /rpt_family="MaLR" /rpt_type=dispersed variation 198 /frequency="0.01" /replace="c" variation 288 /frequency="0.20" /replace="a" repeat_region 306..615 /rpt_family="Alu" /rpt_type=dispersed variation 518 /frequency="0.05" /replace="g" variation 559 /frequency="0.99" /replace="" repeat_region 616..1022 /rpt_family="MaLR" /rpt_type=dispersed variation 628 /frequency="0.18" /replace="t" variation 673 /frequency="0.27" /replace="c" repeat_region 1395..1574 /rpt_family="L2" /rpt_type=dispersed variation 1723 /frequency="0.03" /replace="a" variation 1807 /frequency="0.03" /replace="c" repeat_region 1861..2154 /rpt_family="Alu" /rpt_type=dispersed variation 2103 /frequency="0.12" /replace="t" variation 2143 /frequency="0.05" /replace="t" repeat_region 2228..2412 /rpt_family="MIR" /rpt_type=dispersed variation 2264 /frequency="0.42" /replace="c" variation 2420 /frequency="0.43" /replace="a" repeat_region 2536..2703 /rpt_family="MIR" /rpt_type=dispersed variation 2913 /frequency="0.26" /replace="c" variation 3272 /frequency="0.36" /replace="t" repeat_region 3319..3507 /rpt_family="MIR" /rpt_type=dispersed variation 3543 /frequency="0.01" /replace="a" variation 3631 /frequency="0.37" /replace="g" variation 3664 /frequency="0.38" /replace="c" variation 3755 /frequency="0.03" /replace="" variation 3759 /frequency="0.22" /replace="a" variation 4091 /frequency="0.01" /replace="t" variation 4521 /frequency="0.18" /replace="t" variation 4825 /frequency="0.17" /replace="t" repeat_region 4854..4982 /rpt_family="Alu" /rpt_type=dispersed variation 4876 /frequency="0.01" /replace="a" variation 5138 /frequency="0.34" /replace="t" gene 6029..16610 /gene="IL1A" mRNA join(6029..6078,6743..6797,7757..7805,8695..8917, 10856..11026,12412..12536,15257..16610) /gene="IL1A" /product="interleukin 1, alpha" variation 6173 /gene="IL1A" /frequency="0.27" /replace="t" variation 6279 /gene="IL1A" /frequency="0.18" /replace="a" variation 6291 /gene="IL1A" /frequency="0.17" /replace="a" variation 6716 /gene="IL1A" /frequency="0.04" /replace="a" CDS join(6751..6797,7757..7805,8695..8917,10856..11026, 12412..12536,15257..15457) /gene="IL1A" /codon_start=1 /product="interleukin 1, alpha" /protein_id="AAM96189.1" /db_xref="GI:22385324" /translation="MAKVPDMFEDLKNCYSENEEDSSSIDHLSLNQKSFYHVSYGPLH EGCMDQSVSLSISETSKTSKLTFKESMVVVATNGKVLKKRRLSLSQSITDDDLEAIAN DSEEEIIKPRSAPFSFLSNVKYNFMRIIKYEFILNDALNQSIIRANDQYLTAAALHNL DEAVKFDMGAYKSSKDDAKITVILRISKTQLYVTAQDEDQPVLLKEMPEIPKTITGSE TNLLFFWETHGTKNYFTSVAHPNLFIATKQDYWVCLAGGPPSITDFQILENQA" variation 7685 /gene="IL1A" /frequency="0.01" /replace="c" variation 7893 /gene="IL1A" /frequency="0.19" /replace="c" variation 7921 /gene="IL1A" /frequency="0.36" /replace="a" variation 7954 /gene="IL1A" /frequency="0.03" /replace="t" variation 8014 /gene="IL1A" /frequency="0.19" /replace="c" variation 8126 /gene="IL1A" /frequency="0.43" /replace="t" variation 8225 /gene="IL1A" /frequency="0.03" /replace="a" repeat_region 8313..8366 /rpt_family="Mariner" /rpt_type=dispersed variation 8389 /gene="IL1A" /frequency="0.01" /replace="a" variation 8852 /gene="IL1A" /frequency="0.01" /replace="a" repeat_region 9219..9324 /rpt_family="MIR" /rpt_type=dispersed variation 9289 /gene="IL1A" /frequency="0.01" /replace="a" variation 9316 /gene="IL1A" /frequency="0.18" /replace="c" variation 9319 /gene="IL1A" /frequency="0.19" /replace="c" repeat_region 9366..9460 /rpt_family="MIR" /rpt_type=dispersed variation 9432 /gene="IL1A" /frequency="0.01" /replace="a" repeat_region 9462..9765 /rpt_family="Alu" /rpt_type=dispersed variation 9545 /gene="IL1A" /frequency="0.24" /replace="a" variation 9548 /gene="IL1A" /frequency="0.01" /replace="g" variation 9593 /gene="IL1A" /frequency="0.01" /replace="a" variation 9608 /gene="IL1A" /frequency="0.20" /replace="t" variation 9769..9771 /gene="IL1A" /frequency="0.80" /replace="" repeat_region 9862..9976 /rpt_family="MIR" /rpt_type=dispersed variation 9903 /gene="IL1A" /frequency="0.02" /replace="c" repeat_region 10073..10460 /rpt_family="L1" /rpt_type=dispersed variation 10519 /gene="IL1A" /frequency="0.01" /replace="t" variation 10520 /gene="IL1A" /frequency="0.16" /replace="a" variation 10747 /gene="IL1A" /frequency="0.33" /replace="c" variation 10760 /gene="IL1A" /frequency="0.20" /replace="c" variation 10876 /gene="IL1A" /frequency="0.26" /replace="t" variation 10948 /gene="IL1A" /frequency="0.01" /replace="a" variation 11271 /gene="IL1A" /frequency="0.01" /replace="" repeat_region 11318..11380 /rpt_family="MIR" /rpt_type=dispersed variation 11323 /gene="IL1A" /frequency="0.01" /replace="g" variation 11448 /gene="IL1A" /frequency="0.20" /replace="t" variation 11579 /gene="IL1A" /frequency="0.99" /replace="" repeat_region 11857..12037 /rpt_family="L1" /rpt_type=dispersed variation 12091 /gene="IL1A" /frequency="0.01" /replace="a" variation 12662 /gene="IL1A" /frequency="0.25" /replace="a" variation 12687 /gene="IL1A" /frequency="0.01" /replace="c" variation 12705 /gene="IL1A" /frequency="0.18" /replace="c" repeat_region 12889..13003 /rpt_family="MIR" /rpt_type=dispersed repeat_region 13228..13563 /rpt_family="L2" /rpt_type=dispersed variation 13270 /gene="IL1A" /frequency="0.10" /replace="c" misc_feature 13317..13507 /gene="IL1A" /note="Region not scanned for variation" misc_feature 13854..14259 /gene="IL1A" /note="Region not scanned for variation" repeat_region 14240..14468 /rpt_family="L2" /rpt_type=dispersed variation 14416 /gene="IL1A" /frequency="0.03" /replace="a" variation 14761 /gene="IL1A" /frequency="0.47" /replace="c" variation 14767 /gene="IL1A" /frequency="0.06" /replace="c" variation 14837 /gene="IL1A" /frequency="0.17" /replace="" variation 15216 /gene="IL1A" /frequency="0.19" /replace="c" variation 15454 /gene="IL1A" /frequency="0.01" /replace="a" repeat_region 15746..15834 /rpt_family="MIR" /rpt_type=dispersed repeat_region 15820..15986 /rpt_family="MIR" /rpt_type=dispersed variation 15865 /gene="IL1A" /frequency="0.36" /replace="g" variation 16018 /gene="IL1A" /frequency="0.25" /replace="c" variation 16146 /gene="IL1A" /frequency="0.01" /replace="a" variation 16376 /gene="IL1A" /frequency="0.14" /replace="a" variation 16386..16389 /gene="IL1A" /frequency="0.23" /replace="" variation 16591 /gene="IL1A" /frequency="0.03" /replace="a" variation 16616..16619 /frequency="0.01" /replace="" variation 16814 /frequency="0.35" /replace="t" repeat_region 16892..17194 /rpt_family="Alu" /rpt_type=dispersed variation 17012 /frequency="0.34" /replace="g" variation 17081 /frequency="0.36" /replace="a" repeat_region 17260..17619 /rpt_family="L2" /rpt_type=dispersed variation 17393 /frequency="0.18" /replace="a" repeat_region 17630..18146 /rpt_family="MaLR" /rpt_type=dispersed variation 18006 /frequency="0.23" /replace="a" variation 18268 /frequency="0.32" /replace="c" variation 18311 /frequency="0.01" /replace="g" ORIGIN 1 cccaatttct ttgctgagtc atagcaaggg tgacctttgc ccagttccca acaaattccc 61 catttccatc tgagactttg tcaccctgga cttcattgtc cgtatcacta tcagcatttt 121 ggtcacaacc atttagccag tctctaagaa gttccaaact ttccctcatc ttcttgtttt 181 cttctgagcc ctttaaattc ttccaatctt tgcccattac ccagttccaa agttgactcc 241 acatttttag atatctttat agctatatgc cccattcttc agtaccagtt ttctgtatta 301 agccattctt ttttttttct ttttttcttt tttttgagac ggagtctcac tctgtcgccc 361 aggctggagt gcagtggtgc aatctcggct cactgcaagc tccgcttccc gggttcatgc 421 cattctcctg cctcagcctc cagagtagct gggactacag gcgcccacca ccacgcccga 481 ctaatttttt gtatttttag tagagatgga gtttcaccgt gttagccggt ggtctcaatc 541 tcctgacctc atgttccacc ccccctcagc ctcccacagt gctgggatta caggcgtgag 601 ccaccatgcc cagcctgtat taagccactc ttatgttgct ataaagaaat atctgaggct 661 gggtaattta tatggaaatg aagtttattt tggctcacag ttctgcaggc tgtacaagca 721 tggcacccac atctgctcag cttttggcga agccttagga aactttcaat catggcagag 781 agcgaagggg agcagggatg tcacatgtcg aaagcagtaa caagagagca atgggggagt 841 gccacacact tttaaacaac catatctcag gagaactcat tcactattga gaggacagta 901 ccaagctatt catgagggat ctgcccccat gatccaaaca cctcccacca ggccctacct 961 ccaacactgg ggattacatt tcaacatgag atttggaggg aacaaatacc cagactacat 1021 caatcaccca tctccagaga aaaggaaaag ggaatttaga aacaaaaaaa aaaagcacat 1081 ccatcagaga acagatgagc taaggtgaag aggtaattgt agctaaatag aaatttgctg 1141 actgaacgtg aagctgtccc ttcctgctat ggacttcaga ttttagccca cttgaattgc 1201 tccatatcct ccaagccatg gccatccctt gactctctgg gctcccaagc acttgctgcc 1261 ttcatcacac agtttgagtt aaggcagaaa gactggtttc catgtacact ttgtggaagc 1321 tttctcattt ctttatataa tctctgtcct ttgtctactg ctttaaaatc tagaaattgt 1381 ttacaaacac aaaggtgatc ctttaaaagc tcaaagctga ttgtgtcacc aatatatacc 1441 actcttaatg gcttcccatt aaactttgag taaagacttt atggagccta cataaggcca 1501 tgactacctg gctcttattt tcctcctcat cctcatctca ccaactcact ctccactcct 1561 atacccctca ctccttcccc ctcctctctc tgagctccag actcccaatt acctacttcc 1621 accctttttg acccccaggg acttatctca gcctggaatt ttccctcttt gctctccact 1681 gaactgtcca ctcccagtct aagacatgtg cttatgtcac acgcccttac cgtgcttatc 1741 tcagtttgta attatctact catttagaaa agtgttgatg aaggtcttca ctgtcagctt 1801 tcaggatagc aggaatcata gctgatttta cttacttaac ggggtttcat tctttgtaac 1861 tttttttttt tttgagatgg agactcactc ttgcccaggc tggagtgcaa tggcatgatc 1921 tcggctcact gcaacctcca cctcctgggt tcaagtgatt ctcctgcttc agcctcccga 1981 gtagctggga ttacagatgc ctgtcaccac gcccagctaa ttttttgtat tttttgtaaa 2041 gacggggttt catcatgttg gccaggctgg tctcgatctc ctgacctcag gcgatccacc 2101 cacctcagcc tcccaaagtg ctgtgattac aggcatgagc cacggcaccc agccactcct 2161 tttttactta tgggtgagaa gccattagag attatttctt cttttctttc tctcttcact 2221 aaggcaccag ggtcactaag tagtaggata ctttgaacta gaattcaaga aattgagttt 2281 taattttacc tcacactctc atatgaattc tccatgtgac ctcgggccat acttcccctg 2341 taccctgttt cctcttttat aaaagtaaga gtttaaacta gatggtctcc gacatgcatc 2401 cttctctaac atattctggg accttcaata aactaagata aagcagaata attaaaactt 2461 aatttaaaag aacacaggaa aggaagcagc tacattaagc aaaagagaca tcctcatggt 2521 tgaagaagtg tatgccctgg tgtctggatc ccatttagga aacttggtaa ccttgcaatc 2581 ttgggcagat tgcttaattt ctctagacca tgacttcctc ttctgtaaga tgtgataaga 2641 acatctacct cacaggtttc atgagaggat taaatgagat aatgtattat aatcccttga 2701 acatggtagg ctgttatgtt aagtcctttc ctccttctct gtagctatca tggaatttaa 2761 aaacacatta taactagagc atgagttgcg actaaaggct caattgtctc tgcatgtgtt 2821 ggctcatgca tgctttattc ctctgaagag cttttatacc aagtgaaagg aaataattgc 2881 atttccctga aaattcacag gaaaaagtta tgtttttctc ttcattcaag tgattctgtt 2941 agacccaacc acatgcaaca attttaaagt tgcttccaaa tatatttaca aatatttcct 3001 gtcttcaagg aacaatggca agaccatgac tcaggttcac atccggattc caccactaac 3061 catgtaccca attacttcag tcaccttcat tcaggtctta catatcacag aataaaatca 3121 gatttcatca gaggaggtga agacagggag aggagatatt tcaatccctt ctccgcaacc 3181 cccgtttttt tttttttttt aacaaggatc ctagagttac tgaatgatag cacgtttgag 3241 ggggaaagac cctaaggatg atctttataa gccatcactt ggtgttggtg gtgataagag 3301 actcgagtat ctttatgcag tggaaagaga agattggact cggaatcaga agcttgagtt 3361 caagcactgg tttcatcagt cttgtgatct tgggttggtc acttaacctc ttcaagggtc 3421 ctcagctgtg aaagaggata gtatcagcta attcttgtag gtgcagtgag gaggcagtga 3481 gatagtgcag gtaaactata aaacaattgt cacatgaaac gcatcacagt gattctttgg 3541 acccacaagc tccaatctta taaaacatat ccagtcaccc accaacatag atcatctcac 3601 cttgcatatc tgattttgtg gatcatgggg aaaaactgct gattcctagc aaaacccatg 3661 gcataggata agtgcacaat aatttttttt tcctaaatga tttagatgac agtgactcat 3721 taagggtttc ctgaggcctc ctcagagtcg agaggtgggt gcctgaagcc acccaaagtc 3781 cctgtcacag gatggctccc aacgcacaca ccacaggcct gcccagtatg ttccactatc 3841 tacccagtag agccctgccc agtacgttcc actgtccctt ccctagaaga ggtgactgtt 3901 gttcacagtc ccagaaaagc gggctcccca aaacaatgca aggacccacc tctctctgaa 3961 cctcacccac cctagttttc ctttaaaaat caatttacaa gaagatcatg tgaaggaaaa 4021 ggttgggtga tattctaacc caagttagct gtttctcaac caagttctct ttgaaaaatt 4081 caacaaccac ctttggggaa ttatttacaa cagaggagtg aggatgggac caggataggt 4141 attgcctatg ttggtggaac cagggttttt ttcctggatt accaaagaga tggtatgcat 4201 tgctcccaga agctaaatat cttcaggctt tcaatggtgg ccttcacctg aaaatgttat 4261 ccctgttgaa gctttcaagc cagtattttc ataagaacta tattttcttt ggtgaactga 4321 ggcattataa tgatgactat acaggttctt gagtgactga agccatcatt agcattgtca 4381 ttatttttgt ttagttgcat ctccatagca gctcacattc acaatgtgct ttgcaattgt 4441 tccttagcaa tagccctcac aagattctca ggaggagagg gttaatcagg attaacattt 4501 ctgtgttgcc taaagaggaa ccaaggtaag cagaaatgta gccagttggc tggcatcact 4561 gttgcttcag gattcatcct tagacaccca agcttctacc ctagtctggt gctacactta 4621 cattgcttac atccaagtgt ggttatttct gtggctcctg ttataactat tatagcacca 4681 ggtctatgac caggagaatt agactggcat taaatcagaa taagagattt tgcacctgca 4741 atagacctta tgacacctaa ccaaccccat tatttacaat taaacaggaa cagagggaat 4801 actttatcca actcacacaa gctgctttcc tcccagatcc atgctttttt gcgtttatta 4861 ttttttagag atgggggctt cactatgttg cccacactgg actaaaactc tgggcctcaa 4921 gtgattgtcc tgcctcagcc tcctgaatag ctgggactac aggggcatgc catcacacct 4981 agttcatttc ctctatttaa aatatacatg gcttaaactc caactgggaa cccaaaacat 5041 tcatttgcta agagtctggt gttctaccac ctgaactagg ctggccacag gaattataaa 5101 agctgagaaa ttctttaata atagtaacca ggcaacacca ttgaaggctc atatgtaaaa 5161 atccatgcct tcctttctcc caatctccat tcccaaactt agccactggc ttctggctga 5221 ggccttacgc atacctcccg gggcttgcac acaccttctt ctacagaaga cacaccttgg 5281 gcatatccta cagaagacca ggcttctctc tggtccttgg tagagggcta ctttactgta 5341 acagggccag ggtggagagt tctctcctga agctccatcc cctctatagg aaatgtgttg 5401 acaatattca gaagagtaag aggatcaaga cttctttgtg ctcaaatacc actgttctct 5461 tctctaccct gccctaacca ggagcttgtc accccaaact ctgaggtgat ttatgcctta 5521 atcaagcaaa cttccctctt cagaaaagat ggctcatttt ccctcaaaag ttgccaggag 5581 ctgccaagta ttctgccaat tcaccctgga gcacaatcaa caaattcagc cagaacacaa 5641 ctacagctac tattagaact attattatta ataaattcct ctccaaatct agccccttga 5701 cttcggattt cacgatttct cccttcctcc tagaaacttg ataagtttcc cgcgcttccc 5761 tttttctaag actacatgtt tgtcatctta taaagcaaag gggtgaataa atgaaccaaa 5821 tcaataactt ctggaatatc tgcaaacaac aataatatca gctatgccat ctttcactat 5881 tttagccagt atcgagttga atgaacatag aaaaatacaa aactgaattc ttccctgtaa 5941 attccccgtt ttgacgacgc acttgtagcc acgtagccac gcctacttaa gacaattaca 6001 aaaggcgaag aagactgact caggcttaag ctgccagcca gagagggagt catttcattg 6061 gcgtttgagt cagcaaaggt attgtcctca catctctggc tattaaagta ttttctgttg 6121 ttgtttttct ctttggctgt tttctctcac attgccttct ctaaagctac agcctctcct 6181 ttcttttctt gtccctccct ggtttggtat gtgacctaga attacagtca gatttcagaa 6241 aatgattctc tcattttgct gataaggact gattcgtttt actgagggac ggcagaacta 6301 gtttcctatg agggcatggg tgaatacaac tgaggcttct catgggaggg aatctctact 6361 atccaaaatt attaggagaa aattgaaaat ttccaactct gtctctctct tacctctgtg 6421 taaggcaaat accttattct tgtggtgttt ttgtaacctc ttcaaacttt cattgattga 6481 atgcctgttc tggcaataca ttaggttggg cacataagga ataccaacat aaataaaaca 6541 ttctaaaaga agtttacgat ctaataaagg agacaggtac atagcaaact aattcaaagg 6601 agctagaaga tggagaaaat gctgaatgtg gactaagtca ttcaacaaag ttttcaggaa 6661 gcacaaagag gaggggctcc cctcacagat atctggatta gaggctggct gagctgatgg 6721 tggctggtgt tctctgttgc agaagtcaag atggccaaag ttccagacat gtttgaagac 6781 ctgaagaact gttacaggta aggaataaga tttatctctt gtgatttaat gagggtttca 6841 aggctcacca gaatccagct aggcataaca gtggccagca tgggggcagg ccggcagagg 6901 ttgtagagat gtgtactagt cctgaagtca gagcaggttc agagaagacc cagaaaaact 6961 aagcattcag catgttaaac tgagattaca ttggcaggga gaccgccatt ttagaaaaat 7021 tatttttgag gtctgctgag ccctacatga atatcagcat caacttagac acagcctctg 7081 ttgagatcac atgccctgat ataagaatgg gttttactgg tccattctca ggaaaacttg 7141 atctcattca ggaacaggaa atggctccac agcaagctgg gcatgtgaac tcacatatgc 7201 aggcaaatct cactcagatg tagaagaaag gtaaatgaac acaaagataa aattacggaa 7261 catattaaac taacatgatg tttccattat ctgtagtaaa tactaacaca aactaggctg 7321 tcaaaatttt gcctggatat tttactaagt ataaattatg aaatctgttt tagtgaatac 7381 atgaaagtaa tgtgtaacat ataatctatt tggttaaaat aaaaaggaag tgcttcaaaa 7441 cctttctttt ctctaaagga gcttaacatt cttccctgaa cttcaattaa agctcttcaa 7501 tttgttagcc aagtccaatt tttacagata aagcacaggt aaagctcaaa gcctgtcttg 7561 atgactacta attccagatt agtaagatat gaattactct acctatgtgt atgtgtagaa 7621 gtccttaaat ttcaaagatg acagtaatgg ccatgtgtat gtgtgtgacc cacaactatc 7681 atggtcatta aagtacattg gccagagacc acactgaaat aacaacaatt acattctcat 7741 catcttattt tgacagtgaa aatgaagaag acagttcctc cattgatcat ctgtctctga 7801 atcaggtaag caaatgactg taattctcat gggactgcta ttcttacaca gtggtttctt 7861 catccaaaga gaacagcaat gacttgaatc ttaaatactt ttgttttacc ctcactagag 7921 gtccagagac ctgtctttca ttataagtga gaccagctgc ctctctaaac taatagttga 7981 tgtgcattgg cttctcccag aacagagcag aactatccca aatccctgag aactggagtc 8041 tcctggggca ggcttcatca ggatgttagt tatgccatcc tgagaaaggc cccgcaggcc 8101 gcttcaccag gtgtctgtct cctaacgtga tgtgttgtgg ttgtcttctc tgacaccagc 8161 atcagaggtt agagaaagtc tccaaacatg aagctgagag agaggaagca agccagttga 8221 aagtgagaag tctacagcca ctcatcaatc tgtgttattg tgtttggaga ccacaaatag 8281 acactataag tactgcctag tatgtcttca gtactggctt taaaagctgt ccccaaagga 8341 gtatttctaa aatattttga gcattgttaa gcagattttt aacctcctga gagggaacta 8401 attggaaagc taccactcac tacaatcatt gttaacctat ttagttacaa catctcattt 8461 ttgagcatgc aaataaatga aaaagtcttc ctaaaaaaat catcttttta tcctggaagg 8521 aggaaggaag gtgagacaaa agggagagag ggagggaagc ctaatgaaac accagttacc 8581 taagaccaga atggagatcc tcctcactac ctctgttgaa tacagcacct actgaaagaa 8641 ctttcattcc ctgaccatga acagcctctc agcttctgtt ttccttcctc acagaaatcc 8701 ttctatcatg taagctatgg cccactccat gaaggctgca tggatcaatc tgtgtctctg 8761 agtatctctg aaacctctaa aacatccaag cttaccttca aggagagcat ggtggtagta 8821 gcaaccaacg ggaaggttct gaagaagaga cggttgagtt taagccaatc catcactgat 8881 gatgacctgg aggccatcgc caatgactca gaggaaggta aggggtcaag cacaataata 8941 tctttctttt acagttttaa gcaagtaggg acagtagaat ttaggggaaa attaaacgtg 9001 gagtcagaat aacaagaaga caaccaagca ttagtctggt aactatacag aggaaaatta 9061 atttttatcc ttctccagga gggagaaatg agcagtggcc tgaatcgaga atacttgctc 9121 acagccatta tttcttagcc atattgtaaa ggtcgtgtga cttttagcct ttcaggagaa 9181 agcagtaata agaccactta cgagctatgt tcctctcata ctaactatgc ctccttggtc 9241 atgttacata atcttttcgt gattcagttt cctctactgt aaaatggaga taatcagaat 9301 cccccactca ttggattgtt gtaaagatta agagtctcag gctttacaga ctgagctagc 9361 tgggccctcc tgactgttat aaagattaaa tgagtcaaca tcccctaact tctggactag 9421 aataatgtct ggtacaaagt aagcacccaa taaatgttag ctattactat cattattatt 9481 attattttat tttatttttt tgagatggag tctggctctg tcacccaggc tggagtgcag 9541 tggcgcaatc tcggctcact gcaagctctg cctcctgggt tcatgccatt ctcctgcctc 9601 agcctcccga gtagctggga atacaggcac ccgccactgt tcccggctaa ttttttgtat 9661 ttttagtaga gacggagttt caccgtggtc tccatctcct cgtgatccac ccaccttggc 9721 ctcccaaagt gccgggatta caggcgtgag ccaccgcgcc cggcctatga ttattattat 9781 tattactact actactacct atatgaatac taccagcaat actaatttat taatgactgg 9841 attatgtcta aacctcacaa gaatcctacc ttctcatttt acataaaagg aaactaagct 9901 cattgagata ggtaaactgc ccaatggcat acatctgtaa gtgggagagc ctcaaatcta 9961 attcagttct acctgagtaa aaaaatcatg gtttctcctc catcccttta ctgtacaagc 10021 ctccacatga actataaacc caatattcct gtttttaaga taatacctaa gcaataacgc 10081 atgttcacct agaaggtttt aaaatgtaac aaaatataag aaaataaaaa tcactcatat 10141 cgtcagtgag agtttactac tgccagcact atggtatgtt tccttaaaat ctttgctata 10201 cacataccta catgtgaaca aatatgtcta acatcaagac cacactattt acaactttat 10261 atccagcttt tcttacttag caatgtattg aggacatttt agagtgcccg tttttcacca 10321 ttataagcaa tgcaacaatg aacatctgta taaataaata ttcatttctc tcacccttta 10381 tttccttaga atatattcct agaagtagaa tttcccagag ccatgaggat ttgtgacgct 10441 attgatatgt gccactttgc actctctgtg acatatataa ttatttttaa tgcattcatt 10501 tttttctcag agtgcattcg tttgaaaaca tagacgggaa atactggtag tcttccttgt 10561 cagttagaaa cacccaaaca atgaaaaatg aaaaagttgc acaaatagtc tctaaaaaca 10621 atgaaactat tgcctgagga attgaagttt aaaaagaagc acataagcaa caacaaggat 10681 aatcctagaa aaccagttct gctgactggg tgatttcact tctctttgct tcctcatctg 10741 gattggaata ttcctaatat cccctccaga actattttcc ctgtttgtac tagactgtgt 10801 atatcatctg tgtttgtaca tagacattaa tctgcacttg tgatcatggt tttagaaatc 10861 atcaagccta ggtcagcacc ttttagcttc ctgagcaatg tgaaatacaa ctttatgagg 10921 atcatcaaat acgaattcat cctgaatgac gccctcaatc aaagtataat tcgagccaat 10981 gatcagtacc tcacggctgc tgcattacat aatctggatg aagcaggtac attaaaatgg 11041 caccagacat ttctgtcatc ctcccctcct ttcatttact tatttattta tttcaatctt 11101 tctgcttgca aaaaacatac ctcttcagag ttctgggttg cacaattctt ccagaatagc 11161 ttgaagcaca gcacccccat aaaaatccca agccagggca gaaggttcaa ctaaatctgg 11221 aagttccaca agagagaagt ttcctatctt tgagagtaaa gggttgtgca caaagctagc 11281 tgatgtacta cctctttggt tctttcagac attcttaccc tcaattttaa aactgaggaa 11341 actgtcagac atattaaatg atttactcag atttacccag aagccaatga agaacaatca 11401 ctctccttta aaaagtctgt tgatcaaact cacaagtaac accaaaccag gaagatcttt 11461 attatctctg ataacatatt tgtgaggcaa aacctccaat aagctacaaa tatggcttaa 11521 aggatgaagt ttagtgtcca aaaactttta tcacacacat ccaattttca tggcggacca 11581 tgttttagtt tcaacagtat acatattttc aaaggtccag agaggcaatt ttgcaataaa 11641 caagcaagac tttttctgat tggatgcact tcagctaaca tgctttcaac tctacattta 11701 caaattattt tgtgttctat ttttctactt aatattattt ctgcaatttt cccaatattg 11761 acatcgtgta tgtatttgcc atttttaata tcactagaca attcaatcag gttgctacgt 11821 tggtcccttg ggtttactct aaatagcttg attgcaaata tctttgtata tattattgtt 11881 ttttctccta tcttgtaatt tctttgagca catcccaaag aggaatgcct agatcaatgg 11941 gcacaaataa tttgacagct cttattaaac attattctgt aagtaaaaac tgaactactt 12001 ttcagtatca ctagcaacat atgagtgtat cagcttccta aacccctcca tgttaggtca 12061 ttatgaactt atgatctaac aaattacagg gtcttatccc actaatgaaa ttataagaga 12121 ttcaacactt attcagcccc gaaggattca ttcaacgtag aaaattctaa gaacattaac 12181 caagtattta cctgcctagt gagtgtggaa gacattgtga aggacacaaa gatgtataga 12241 attccattcc tgacttccag gtatttacac cataggtggg gacctaacta cacacacaca 12301 cacacacaca cacacacaca cacacacacc atgcacacac aatctacatc aacacttgat 12361 tttatacaaa tacaatgaat ttactttctt tttggttctt ctcttcacca gtgaaatttg 12421 acatgggtgc ttataagtca tcaaaggatg atgctaaaat taccgtgatt ctaagaatct 12481 caaaaactca attgtatgtg actgcccaag atgaagacca accagtgctg ctgaaggtca 12541 gttgtccttt gtctccaact taccttcatt tacatctcat atgtttgtaa ataagcccaa 12601 taggcagaca cctctaacaa ggtgacactg tcctctttcc ttcctaccac agcccccacc 12661 tgcccacccc actcccattg attccagagg cgtgcctagg caggatctat gagaaaatat 12721 aacagagagt aagaggaaaa ttaccttctt tctttttcct ttccctgcct gaccttattc 12781 acctcccatc ccagagcatc catttattcc attgatcttt actgacatct attatctgac 12841 ctacacaata ctagacatta ggacaatgtg gcctgcctcc aagaaactca aataagccaa 12901 ctgagatcag agaggattaa tcacctgcca atgggcacaa agcaacaagc tgggagccaa 12961 gtcccaaaat ggggcctgct gcttccagtt cccctctctc tgcattgatg tcagcattat 13021 ccttcgtccc agtcctgtct ccactaccac tttccccctc aaacacacac acacacaaca 13081 gccttagatg ttttctccac tgataagtag gtgactcaat ttgtaagtat ataatccaag 13141 accttctatt cccaagtaga atttatgtgc ctgcctgtgc ttttctacct ggatcaagtg 13201 atgtctacag agtagggcag tagcttcatt catgaactca ttcaacaagc attattcact 13261 gagagccttg tatttttcag gcatagtgcc aacagcagtg tggacagtgg tgcatcaaag 13321 cctctagtct catagaactt agtcttctgg aggatatgga aaacagacaa cccaaacaac 13381 caacaaaaga gcaagatgct gcaaaaaaaa aaaaaaatga atagggtgct aagatagaga 13441 aaagtgggag agtgctattt agacaaagtg gtaaaaacaa agccccttgt gagatgagag 13501 ctgccgacag gagggggcgg gtcatggttg tgggtttttg ggtaggacat tcagaggagg 13561 gggcgggtcg tggttgtggg tttttgggta ggacattcag aggagggggc gggtcgtggt 13621 tgtgggtttt tgggtaggac attcagagga gggggcgggt cgtggttgtg ggtttttggg 13681 taggacattc agaggagggg gcgggtcgtg gttgtgggtt tttgggtagg acattcagag 13741 gagggggcgg gtcgtggttg tgggtttttg ggtaggacat tcagaggagg gggcgggtcg 13801 tggttgtggg tttttgggta ggacattcag aggagggggc gggtcgtggt tgtgggtttt 13861 tgggtaggac attcagagga gggggcgggt cgtggttgtg ggtttttggg taggacattc 13921 agaggagggg gcgggtcgtg gttgtgggtt tttgggtagg acattcagag gagggggcgg 13981 gtcgtggttg tgggtttttg ggtaggacat tcagaggagg gggcgggtcg tggttgtggg 14041 tttttgggta ggacattcag aggagggggc gggtcatggt tgtgggtttt tgggacattc 14101 agaggagtct gaatgcaccc aggcctacaa cttcaagatg gtaaaggaca gctccaagga 14161 tcagaagaag cattcttgga actggggcat tttgagaagg aggaaaaata tgcagagact 14221 agtgcttgca gagcttgcat ttggatttca tttgaggtac aatgaaaacc cattaatggg 14281 tttcacacag tgcaatggcc tgacctcact tatatttcct aaaatagaaa acagatcaga 14341 aggaaggcaa tagagaagca gaaagtccaa tgaggaggtt tcacagcagt catgggggtg 14401 gggtaaggaa aagaagtgga aagaaacaga cagaattggg ttatattttg gagatagaac 14461 caacagaagg aagaggagaa acaacattta ctgagaaggg aaaaagtagg agaggaatag 14521 gtttgggaaa taaatcctgc tgacattgga aaccccaagg aagcctcaaa agtatattta 14581 cttgctttag atttaaaaga ataggaaaga agcatctcaa cttggaattt gaaatctatt 14641 tttccataaa agtattgtta aattctactc atactcacaa gaaaagtaca ttctaaagag 14701 tatattgaaa gagtttactg atatacttag gaattttgtg tgtatgtgtg tgtgtgtatg 14761 tgtgtgtgtg tgtttaacct tcaattgttg acttaaatac tgagataaat gtcatctaaa 14821 tgctaaattg atttcccaaa ggtatgattt gttcacttgg agatcaaaat gtttaggggg 14881 cttagaatca ctgtagtgct cagatttgat gcaaaatgtc ttaggcctat gttgaaggca 14941 ggacagaaac aatgtttccc tcctacctgc ctggatacag taagatacta gtgtcactga 15001 caatcttcat aactaattta gatctctctc caatcaacta aggaaatcaa ctcttattaa 15061 tagactgggc cacacatcta ctaggcatgt aataaatgct tgctgaatga acaaatgaat 15121 gaagagccta tagcatcatg ttacagccat agtcctaaag tgctgtttct catgaaggcc 15181 aaatgctaag ggattgagct tcagtccttt ttctaacatc ttgttctcta acagaattct 15241 cttcttttct tcataggaga tgcctgagat acccaaaacc atcacaggta gtgagaccaa 15301 cctcctcttc ttctgggaaa ctcacggcac taagaactat ttcacatcag ttgcccatcc 15361 aaacttgttt attgccacaa agcaagacta ctgggtgtgc ttggcagggg ggccaccctc 15421 tatcactgac tttcagatac tggaaaacca ggcgtaggtc tggagtctca cttgtctcac 15481 ttgtgcagtg ttgacagttc atatgtacca tgtacatgaa gaagctaaat cctttactgt 15541 tagtcatttg ctgagcatgt actgagcctt gtaattctaa atgaatgttt acactctttg 15601 taagagtgga accaacacta acatataatg ttgttattta aagaacaccc tatattttgc 15661 atagtaccaa tcattttaat tattattctt cataacaatt ttaggaggac cagagctact 15721 gactatggct accaaaaaga ctctacccat attacagatg ggcaaattaa ggcataagaa 15781 aactaagaaa tatgcacaat agcagttgaa acaagaagcc acagacctag gatttcatga 15841 tttcatttca actgtttgcc ttctactttt aagttgctga tgaactctta atcaaatagc 15901 ataagtttct gggacctcag ttttatcatt ttcaaaatgg agggaataat acctaagcct 15961 tcctgccgca acagtttttt atgctaatca gggaggtcat tttggtaaaa tacttcttga 16021 agccgagcct caagatgaag gcaaagcacg aaatgttatt ttttaattat tatttatata 16081 tgtatttata aatatattta agataattat aatatactat atttatggga accccttcat 16141 cctctgagtg tgaccaggca tcctccacaa tagcagacag tgttttctgg gataagtaag 16201 tttgatttca ttaatacagg gcattttggt ccaagttgtg cttatcccat agccaggaaa 16261 ctctgcattc tagtacttgg gagacctgta atcatataat aaatgtacat taattacctt 16321 gagccagtaa ttggtccgat ctttgactct tttgccatta aacttacctg ggcattcttg 16381 tttcattcaa ttccacctgc aatcaagtcc tacaagctaa aattagatga actcaacttt 16441 gacaaccatg agaccactgt tatcaaaact ttcttttctg gaatgtaatc aatgtttctt 16501 ctaggttcta aaaattgtga tcagaccata atgttacatt attatcaaca atagtgattg 16561 atagagtgtt atcagtcata actaaataaa gcttgcaaca aaattctctg acacatagtt 16621 attcattgcc ttaatcatta ttttactgca tggtaattag ggacaaatgg taaatgttta 16681 cataaataat tgtatttagt gttactttat aaaatcaaac caagatttta tatttttttc 16741 tcctctttgt tagctgccag tatgcataaa tggcattaag aatgataata tttccgggtt 16801 cacttaaagc tcacattaca catacacaaa acatgtgttc ccatctttat acaaactcac 16861 acatacagag ctacattaaa aacaactaat aggccaggca cggtggctca gacctgtaat 16921 cccagcactt tgggaggcca aggtgggaag atcacttgag gtcaggagtt caagaccagc 16981 ctaggcaaca tagtgagatc tcatctctac aaaaaaaaat gaaaaattaa aaaatgagct 17041 ggacatggta gtacacacct gtagtcccag ctactcggga ggcttgaggt gggaggatca 17101 cttgagcctg ggagatggag gctgcagtga gccataatca caccattgca ccccaacctg 17161 ggcaacagag tgagacccag tctcaaaaga taaattttta aaaatgttaa aaaatatata 17221 aaagagaatt ttaaaagaac aactaataga tcaaagcatg gatgcaagat atatttagtt 17281 ggaaaatcaa ggttaaaatc aagggatctt ggaattaggt gtggtagatt tgggtaagga 17341 gtagtctaag atgaccctgt ttcttggtac tggagactgg atgagtggca gcgtcttaac 17401 catatttttg gtagaaatat ggaggtcttc tccattccag gatgaatgat gagtaaaatt 17461 ttaggcatgt aatttgagct actagaagga cactcaattg cagatgtaca atggggagat 17521 gataacctat ctggaactca gaaaaataac tgtatataga tatgaaagac atcagtaggt 17581 atgtagtaga taaaatccta aaagtgatgt caaagggaga agagaagtat atggtgaaca 17641 ctgttgtttg tccatgcaat tgccatctct tcttcttcct tactgacaga accctgattt 17701 cactgagaag tcaacatgcc cttccccaat tgatgaatcc aattggttta agattatgtt 17761 cattctattc ttacatgact aagtcacgtt gacttaatcc tatcaaatga gatgtcgatc 17821 tggaaacaac ttctggaaaa gattttctac cttgataaaa taaagagcca tatagatggt 17881 cctttatctt ccttcttcct tgaatgagat atgttctatg aggaagtgaa gcttagaact 17941 gtggtcagca acttgcaacg actgggaagt cagagccaca caatgaagaa tgcagagtgg 18001 aaggagaaaa agagccagca tctctgacaa cattgttaca ccgagaacct acctccagat 18061 tttaagaaaa caagaaatgc tactgttatt aagccatttc actgggtttg ctatgacttg 18121 cagtcaaatc tagcttaact gatacagagc accacagaga actggtctct catttgtctc 18181 atcctgttct ttctagcagc cacgactttc ctagggtttc cttagcccaa gtctggctag 18241 agcaagacta agtaagactt gattccttaa tgtccttttg ttttaagaaa tattaaagaa 18301 ttatttttat attaatatat tttaagaaat aaggaaatac aaaacactga gcaagcaaca 18361 caaattcaag aaatcttaaa aagtataata gctgctcagt ctctgattaa cagtgaaata 18421 tggaatcatt gtagaaatgg ccttgg //