LOCUS AF400075 18351 bp DNA linear PRI 18-JAN-2002 DEFINITION Homo sapiens coagulation factor II (thrombin) receptor-like 1 (F2RL1) gene, complete cds. ACCESSION AF400075 VERSION AF400075.1 GI:15021772 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 18351) AUTHORS Rieder,M.J., Carrington,D.P., Chung,M.-W., Lee,K.L., Poel,C.L., Yi,Q. and Nickerson,D.A. TITLE Direct Submission JOURNAL Submitted (17-JUL-2001) Molecular Biotechnology, University of Washington, 1705 NE Pacific, Seattle, WA 98195, USA COMMENT To cite this work please use: SeattleSNPs. NHLBI Program for Genomic Applications, UW-FHCRC, Seattle, WA (URL: http://pga.mbt.washington.edu) This sequence consists of 2 contigs. The gap between the contigs is represented as a run of N. 1 10774: contig of 10774 bp in length 10775 10874: gap of unknown length 10875 18351: contig of 7477 bp in length. FEATURES Location/Qualifiers source 1..18351 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" repeat_region 343..492 /rpt_family="MIR" /rpt_type=dispersed variation 467 /frequency="0.09" /replace="a" variation 531 /frequency="0.01" /replace="g" variation 678 /frequency="0.01" /replace="c" repeat_region 728..780 /rpt_family="L2" /rpt_type=dispersed variation 829 /frequency="0.03" /replace="a" repeat_region 913..1028 /rpt_family="FLAM_C" /rpt_type=dispersed variation 925 /frequency="0.01" /replace="t" repeat_region 1059..1214 /rpt_family="L3" /rpt_type=dispersed repeat_region 1292..1578 /rpt_family="AluSg" /rpt_type=dispersed variation 1538 /frequency="0.01" /replace="g" variation 1622 /frequency="0.02" /replace="t" variation 1623 /frequency="0.01" /replace="g" repeat_region 1795..1926 /rpt_family="MIR" /rpt_type=dispersed variation 2122 /frequency="0.01" /replace="g" variation 2254 /frequency="0.01" /replace="c" variation 2457 /frequency="0.10" /replace="g" gene 2462..17176 /gene="F2RL1" mRNA join(2462..2687,15958..17176) /gene="F2RL1" /product="coagulation factor II (thrombin) receptor-like 1" variation 2561 /gene="F2RL1" /frequency="0.28" /replace="c" CDS join(2606..2687,15958..17069) /gene="F2RL1" /codon_start=1 /product="coagulation factor II (thrombin) receptor-like 1" /protein_id="AAK77914.1" /db_xref="GI:15021773" /translation="MRSPSAAWLLGAAILLAASLSCSGTIQGTNRSSKGRSLIGKVDG TSHVTGKGVTVETVFSVDEFSASVLTGKLTTVFLPIVYTIVFVVGLPSNGMALWVFLF RTKKKHPAVIYMANLALADLLSVIWFPLKIAYHIHGNNWIYGEALCNVLIGFFYGNMY CSILFMTCLSVQRYWVIVNPMGHSRKKANIAIGISLAIWLLILLVTIPLYVVKQTIFI PALNITTCHDVLPEQLLVGDMFNYFLSLAIGVFLFPAFLTASAYVLMIRMLRSSAMDE NSEKKRKRAIKLIVTVLAMYLICFTPSNLLLVVHYFLIKSQGQSHVYALYIVALCLST LNSCIDPFVYYFVSHDFRDHAKNALLCRSVRTVKQMQVSLTSKKHSRKSSSYSSSSTT VKTSY" variation 2667 /gene="F2RL1" /frequency="0.02" /replace="t" variation 2770 /gene="F2RL1" /frequency="0.09" /replace="a" variation 3069 /gene="F2RL1" /frequency="0.03" /replace="a" variation 3119 /gene="F2RL1" /frequency="0.32" /replace="t" variation 3151 /gene="F2RL1" /frequency="0.01" /replace="g" variation 3263 /gene="F2RL1" /frequency="0.33" /replace="g" variation 3306 /gene="F2RL1" /frequency="0.02" /replace="t" variation 3330 /gene="F2RL1" /frequency="0.01" /replace="c" variation 3331 /gene="F2RL1" /frequency="0.07" /replace="t" variation 3353 /gene="F2RL1" /frequency="0.01" /replace="a" variation 3417 /gene="F2RL1" /frequency="0.01" /replace="c" variation 4160 /gene="F2RL1" /frequency="0.01" /replace="c" variation 4456 /gene="F2RL1" /frequency="0.01" /replace="" variation 4500 /gene="F2RL1" /frequency="0.02" /replace="t" variation 4663 /gene="F2RL1" /frequency="0.46" /replace="t" repeat_region 4710..4817 /rpt_family="L2" /rpt_type=dispersed variation 4715 /gene="F2RL1" /frequency="0.15" /replace="g" variation 4972 /gene="F2RL1" /frequency="0.02" /replace="c" repeat_region 4993..5299 /rpt_family="AluSx" /rpt_type=dispersed variation 5065 /gene="F2RL1" /frequency="0.01" /replace="g" variation 5159 /gene="F2RL1" /frequency="0.01" /replace="" variation 5295 /gene="F2RL1" /frequency="0.01" /replace="t" variation 5296 /gene="F2RL1" /frequency="0.01" /replace="a" variation 5366 /gene="F2RL1" /frequency="0.17" /replace="t" repeat_region 5643..5940 /rpt_family="AluSx" /rpt_type=dispersed variation 5684 /gene="F2RL1" /frequency="0.02" /replace="g" variation 5786 /gene="F2RL1" /frequency="0.02" /replace="t" variation 5791 /gene="F2RL1" /frequency="0.02" /replace="t" variation 5931 /gene="F2RL1" /frequency="0.49" /replace="g" variation 6175 /gene="F2RL1" /frequency="0.01" /replace="c" variation 6257 /gene="F2RL1" /frequency="0.01" /replace="a" variation 6275 /gene="F2RL1" /frequency="0.01" /replace="g" variation 6361..6365 /gene="F2RL1" /frequency="0.02" /replace="" repeat_region 6373..6664 /rpt_family="AluY" /rpt_type=dispersed variation 6476 /gene="F2RL1" /frequency="0.09" /replace="c" variation 6586 /gene="F2RL1" /frequency="0.01" /replace="a" variation 6647 /gene="F2RL1" /frequency="0.45" /replace="a" variation 6673 /gene="F2RL1" /frequency="0.01" /replace="t" variation 6701 /gene="F2RL1" /frequency="0.48" /replace="a" repeat_region 6792..7099 /rpt_family="AluSx" /rpt_type=dispersed variation 6843 /gene="F2RL1" /frequency="0.01" /replace="" variation 6861 /gene="F2RL1" /frequency="0.01" /replace="a" variation 6946 /gene="F2RL1" /frequency="0.01" /replace="t" variation 6961 /gene="F2RL1" /frequency="0.46" /replace="a" variation 7007 /gene="F2RL1" /frequency="0.01" /replace="t" variation 7008 /gene="F2RL1" /frequency="0.01" /replace="g" variation 7193 /gene="F2RL1" /frequency="0.99" /replace="" repeat_region 7236..7528 /rpt_family="AluY" /rpt_type=dispersed repeat_region 7594..7735 /rpt_family="AluYa5" /rpt_type=dispersed variation 7687 /gene="F2RL1" /frequency="0.01" /replace="a" repeat_region 7774..8047 /rpt_family="AluSg" /rpt_type=dispersed variation 7979 /gene="F2RL1" /frequency="0.46" /replace="c" repeat_region 8053..8275 /rpt_family="L1MC" /rpt_type=dispersed variation 8060 /gene="F2RL1" /frequency="0.01" /replace="" repeat_region 8428..8727 /rpt_family="AluSc" /rpt_type=dispersed variation 8462 /gene="F2RL1" /frequency="0.31" /replace="a" variation 8573 /gene="F2RL1" /frequency="0.02" /replace="a" variation 8630 /gene="F2RL1" /frequency="0.02" /replace="t" variation 8990 /gene="F2RL1" /frequency="0.01" /replace="c" repeat_region 9405..9554 /rpt_family="L1MC5" /rpt_type=dispersed repeat_region 9634..9940 /rpt_family="L1MB7" /rpt_type=dispersed variation 9783 /gene="F2RL1" /frequency="0.01" /replace="c" repeat_region 9941..10190 /rpt_family="AluSx" /rpt_type=dispersed variation 9986 /gene="F2RL1" /frequency="0.06" /replace="a" variation 10063 /gene="F2RL1" /frequency="0.01" /replace="c" variation 10117 /gene="F2RL1" /frequency="0.01" /replace="g" repeat_region 10191..10289 /rpt_family="L1MB7" /rpt_type=dispersed repeat_region 10290..10573 /rpt_family="AluJo" /rpt_type=dispersed variation 10318 /gene="F2RL1" /frequency="0.02" /replace="t" variation 10535 /gene="F2RL1" /frequency="0.01" /replace="c" repeat_region 10574..10587 /rpt_family="L1MB7" /rpt_type=dispersed repeat_region 10623..10755 /rpt_family="AluY" /rpt_type=dispersed variation 10671 /gene="F2RL1" /frequency="0.13" /replace="t" variation 10681 /gene="F2RL1" /frequency="0.06" /replace="a" variation 10722 /gene="F2RL1" /frequency="0.14" /replace="g" variation 10727 /gene="F2RL1" /frequency="0.01" /replace="c" variation 10732 /gene="F2RL1" /frequency="0.01" /replace="g" repeat_region 10875..11166 /rpt_family="AluSg" /rpt_type=dispersed variation 11016 /gene="F2RL1" /frequency="0.17" /replace="a" repeat_region 11167..11226 /rpt_family="L1MB7" /rpt_type=dispersed variation 11216 /gene="F2RL1" /frequency="0.02" /replace="g" repeat_region 11259..11538 /rpt_family="AluSx" /rpt_type=dispersed repeat_region 11539..11587 /rpt_family="L1MB7" /rpt_type=dispersed repeat_region 11592..11747 /rpt_family="L1MC5" /rpt_type=dispersed variation 11653 /gene="F2RL1" /frequency="0.01" /replace="g" repeat_region 11748..12063 /rpt_family="AluJo" /rpt_type=dispersed variation 11998 /gene="F2RL1" /frequency="0.01" /replace="a" variation 12000 /gene="F2RL1" /frequency="0.01" /replace="a" repeat_region 12064..12103 /rpt_family="L1MC5" /rpt_type=dispersed repeat_region 12104..12399 /rpt_family="AluSx" /rpt_type=dispersed variation 12199 /gene="F2RL1" /frequency="0.01" /replace="g" variation 12239 /gene="F2RL1" /frequency="0.01" /replace="c" variation 12273 /gene="F2RL1" /frequency="0.04" /replace="g" variation 12321 /gene="F2RL1" /frequency="0.01" /replace="c" variation 12364 /gene="F2RL1" /frequency="0.01" /replace="t" repeat_region 12400..12511 /rpt_family="L1MC5" /rpt_type=dispersed repeat_region 12531..12665 /rpt_family="FLAM_C" /rpt_type=dispersed repeat_region 12667..12815 /rpt_family="L1MC5" /rpt_type=dispersed variation 12722 /gene="F2RL1" /frequency="0.01" /replace="a" variation 12756 /gene="F2RL1" /frequency="0.01" /replace="c" repeat_region 12938..13147 /rpt_family="MER112" /rpt_type=dispersed variation 13020 /gene="F2RL1" /frequency="0.01" /replace="g" variation 13245 /gene="F2RL1" /frequency="0.45" /replace="a" repeat_region 13249..13541 /rpt_family="MLT1D" /rpt_type=dispersed variation 13531 /gene="F2RL1" /frequency="0.01" /replace="a" repeat_region 13542..13843 /rpt_family="AluSg" /rpt_type=dispersed variation 13605 /gene="F2RL1" /frequency="0.09" /replace="a" repeat_region 13844..14031 /rpt_family="MLT1D" /rpt_type=dispersed variation 13949 /gene="F2RL1" /frequency="0.32" /replace="a" variation 14016 /gene="F2RL1" /frequency="0.01" /replace="g" variation 14128 /gene="F2RL1" /frequency="0.01" /replace="a" variation 14220 /gene="F2RL1" /frequency="0.03" /replace="c" variation 14578 /gene="F2RL1" /frequency="0.50" /replace="g" repeat_region 14804..15095 /rpt_family="AluSx" /rpt_type=dispersed variation 14829 /gene="F2RL1" /frequency="0.13" /replace="t" repeat_region 15161..15290 /rpt_family="FLAM_C" /rpt_type=dispersed repeat_region 15432..15590 /rpt_family="L1ME4A" /rpt_type=dispersed variation 15447 /gene="F2RL1" /frequency="0.14" /replace="" repeat_region 15591..15865 /rpt_family="AluJo" /rpt_type=dispersed variation 15777 /gene="F2RL1" /frequency="0.48" /replace="c" variation 15810 /gene="F2RL1" /frequency="0.13" /replace="a" repeat_region 15866..15897 /rpt_family="L1ME4A" /rpt_type=dispersed variation 15954 /gene="F2RL1" /frequency="0.01" /replace="g" variation 16496 /gene="F2RL1" /frequency="0.01" /replace="t" variation 16684 /gene="F2RL1" /frequency="0.02" /replace="a" variation 16746 /gene="F2RL1" /frequency="0.01" /replace="g" variation 17090 /gene="F2RL1" /frequency="0.01" /replace="a" variation 17098 /gene="F2RL1" /frequency="0.02" /replace="g" variation 17147 /gene="F2RL1" /frequency="0.01" /replace="c" variation 17256..17261 /frequency="0.96" /replace="" repeat_region 17444..17576 /rpt_family="MIR3" /rpt_type=dispersed variation 17492 /frequency="0.01" /replace="a" variation 17512 /frequency="0.02" /replace="c" variation 17566 /frequency="0.14" /replace="a" repeat_region 17640..17912 /rpt_family="AluSx" /rpt_type=dispersed variation 17649 /frequency="0.01" /replace="t" variation 17683 /frequency="0.99" /replace="" variation 17791 /frequency="0.02" /replace="t" repeat_region 17931..18056 /rpt_family="MER5A" /rpt_type=dispersed variation 18088 /frequency="0.01" /replace="t" variation 18092 /frequency="0.01" /replace="g" ORIGIN 1 gtactgttcc acacagccat acaatactcc aatcccttca gggcgaagga gtcatcaaca 61 cctgaaaaac aaatactata ctcccaaaat tacagaaaaa cacctgcaaa ctgactcaag 121 tgagtttagt tcatttagtc aggctggggg aagaaaccac atttttgaga taattaactc 181 atagcattgt tcaataaagt cttttattgg aaattgtgat gattcaaggc atattcccat 241 aaaatacagt gaaaatttaa atcgaaagca gctggaccct gatgtattgt tctctgaaag 301 aggaagattc caccttaaag gcagtcattc tatagcagtt cccatttctt aggtgcttac 361 tatataccag aaacggtact aagaagtgct ttatggacat ttagcaaagt gaatcctcac 421 aaccacccta cgagagaggt actagtatca ttcccagatg atagatgtaa tattaataag 481 ctacagatga ggaaatggat gcttgaaaag tttgaaggga catcttagga atcagttatc 541 tcccctgggg agggaccttc aggaatggcc tgatccctat caggagagct gtccgctgtt 601 caggatgtca aaggttcctg ttctgcttct agaagtcagc ttttcctggg aggaaaagtg 661 ggcatgggct gaggtgagag ctggggtgca ggtggagtat gaagactcct cagagaaagg 721 aaataaacaa aaaatattta ttgagcttct accatgtatc aaacccagtc actagtcact 781 attttatcct cagacagaca cctataaacc tttaaaccac gtgtgtgtgt atatatatat 841 atattataag aaagcttaga gaggataagt aaacttggga tcacacagat gtcaacaagg 901 ggagaagcct gtccgggtgt ggtggctcat tcctgtaatc ccagcacttt gggaggctga 961 gtggggagga tcacatgaag ccaggagttc cagaccagac tggacaagat agggagaccc 1021 cacttctatt ttctaataga aattaaaata aaaaataaag aaaatttctt tatacattga 1081 gctgaaatta aaccccactg tggcttccac caatttttgc tctctggagc aactcaaaac 1141 acatctaaat cctcttctac aagcgaatcc tttaaatatt tgaaaatacc tatgtctctc 1201 ttctgtgctc ttctggtacc aatagtttaa atgggtaaca gtagactttg ttttattcaa 1261 tcttttaaaa agcaaataaa aagtaagaca tgctgggtgc ggtggctcac gcctgtaatc 1321 gcagcacttt gggaggcgga ggtgggctga tcacgaggtc aggagttcga gactagccag 1381 accaacatgg tgaaaccccg cctctactaa aaatacaaaa attagccaga tgtggtgcac 1441 gcctgtaact ccagctactc gggaggctgc ggccagagaa ttgcttgaac ccaggagaca 1501 aagtttgcag tgagccgaga tcacgccact gcactccagc ctgggagaca gagcgagact 1561 ccgtctcaaa aacaaaaagt aagacattac caatatgatg ccaaccctca tgcactcatc 1621 cccaacccca cacttctctt ctcccacccc ttctatctgc ttttgtattt atttagccta 1681 tgggatccca atgcagagga gccctggtgg acgcatttat agtgcagcga tgaatagaag 1741 acagtgatag tcttatactg gagttgaaat gtgataaaca tttatacact gtgtttataa 1801 gtcgtgtaac tctggccaat ttatctggtc tttctaagct cactttcctc gtctgtaaaa 1861 tgggaagaat aatcatactt attgcgctgg ttgttatggg gattaagcaa gataattctc 1921 taaagctttg gcacttggcg ctgaaagtag ccattccatg tcttctttcc cgccccgcct 1981 cttgtgctcc ccaccgcttt cgtgatgtcc gcagttgccc acctgcctct acaataaaaa 2041 acgcatccct cctcctgcag ggtccaccgc accgggaagc cctgtctgta tcagttacca 2101 accacaattg cagtgagtac gaatcgtggc tttcccacag tcaggaaagg caagggagac 2161 cgacgacccg cttctctagg agtaagtaaa gattaaaggt agttcgcggt atagcctagg 2221 cagggattaa cccgtggtcc cagcgctcct gctatttgca ttccaaagca gacacctcat 2281 gcgctcaacc ccgcccgcag gcggctcccg cagtctaagg gacctggcgc gagtccggga 2341 agcggagggc gcacgtgcgc agggaagggg gccgggggcg ggaccagggc gcgcgttccg 2401 gtcccggggc gtggcctccc gcaggtgagt acgctgctcc ttcggtttcc ctgaaaccta 2461 acccgccctg gggaggcgcg cagcagaggc tccgattcgg ggcaggtgag aggctgactt 2521 tctctcggtg cgtccagtgg agctctgagt ttcgaatcgg tggcggcgga ttccccgcgc 2581 gcccggcgtc ggggcttcca ggaggatgcg gagccccagc gcggcgtggc tgctgggggc 2641 cgccatcctg ctagcagcct ctctctcctg cagtggcacc atccaaggtg agaaacctgg 2701 ccaaggaggg ctcttatctc tgaggagctg gggtcctggg cacgctgggc agacggtggg 2761 atccgggcag gtgtgcgaag gctgttctgc tgccggcacc catctctacg aatcccttag 2821 cctccccttg gtggctttga tgtgaggtct ctgcgccaag gaggcaccca ggtgggacat 2881 gcgggagcag ctgaagtcag cggagccggg cagaggcaga gatttcccca aagaccccac 2941 ttcccgtaga ggctgtcatg ctgggcacct ccaggcccca gcgtgggttc ggggaaaggg 3001 agggaaggaa ggagtagctg tgtctaaagg gtacgcagag gacctagtcc cctccccggg 3061 cttggttgct ttgtaaacac taagtcatta agagcttttt gccaactccg gagacttcct 3121 ccgctggccc cgcggggccg gtggggttag cgagctgatt gcgcagggca gggcggagtg 3181 ggtgggaacc cgcggcccgg gagccttcta ggttgttttt tgcgtccctc tccaactgct 3241 ggaagccttt cttcgggttc tgccccctgc gttcgagacc cacccgggtc ccgctgctcc 3301 tggcacccac agtggaaggc ccggggtatg aaagtcaggg ccggtccctg atgggttctg 3361 gtggtaatga gcgctcaggc ccgttgggcg ccacgaggat ttacgagcgg aactttttgg 3421 accctgcctt atatttgacc agttgaccct ctgggcctgg ggttccggga ctttcctagt 3481 gtgccacccg gagcggccac tggctgccac ccaggtctgc aggccagagg ctggctggcc 3541 tgggaacaga gcagcacttg cgcccggccg tcgcgttcct tggatgtgct gctccgggtg 3601 tgctcgaact tgtattgctg ggagtgtgtt cttccgggcc cagcaggcct cgctgtggcc 3661 gtgggggatg tttgacctgc gatcgcgcca ctgtgatcct aaccgaggcc cctctgtttg 3721 gggcagcctg ggtagcaaag ggagctttta atttccctca gaaatgcgca tttctcactt 3781 ttatcctcct cttcataaag acgaagtaaa agagcaagtc acagtgggtt ggaattagat 3841 ggaagaatgt gattcttttc cctctgcagt tagggaaaag ggtgttaatg gtgtaagctt 3901 gaaaactgtg caccgctggt atattttttt ttcttaatca gcatcagaat aaaggcattt 3961 agttccagga agtattgaaa actgtaatgg acacctctcc tctatgtcct ttaaagttgg 4021 aaacttaaaa ttcaggagca aaggttagta tgtgcaaact ttaaaaaaat acatgttggt 4081 atagctgatt caacatcttt atgattcaga gatccctgta ggaagcatgc cccgattatt 4141 tgtcttgttc ttgtttacta ctcttggggg attgggagat ccctggatta taaggcgaac 4201 ttgatttaac aataaggaaa aatcaggtta cttgttaact atagccactt aatattgcac 4261 cttgttcctc atcctccccc caccatactt ttattccctt gcaaagtaac tttcccaaag 4321 ggttagtgaa gtaacactga caattgattt aggcagatgg agctttcctc ccaccttaaa 4381 actaaattga ttttaataag aaatacagtg ttagcaaagc ttttctgccc tcagggtggg 4441 tctttgctca ctcgcttttt agccggtcct tctgcgtgcc cctcaggtgg ctgcagggcc 4501 gatttggggt ttgattttct tcccaaagcc tcactccaaa agactgcctc atagaaacga 4561 actcagccga gatcacaacc ttctcagggt acaggtgaag gacactgaat tgaggaggca 4621 aggcaaggaa aacacttgga aatcagggct tctctttccc ttcacaatag taattgataa 4681 ttatttgggt aaacatgctt aatatgtgtc ctcactgcat cgttaactcc tggaggcagg 4741 gggccctacc atcctttcca tcacgtctag catagtctca tcacctacgg gacctcagta 4801 aatagcaaat gaatgaagtg aggagtcttg cccagagtac cctggctggt ccatgtggtg 4861 ttcatttcag tcagcttctc tctgccactt acttattttt ttccaccatg ttacaggcct 4921 aggtcattcc atttatcttt tggagactgg aacttctgtt ttctttataa ttggtttggt 4981 ggtttttttt tgtttttttg gttttttggg tttttttttt ttttgactct cattcggttg 5041 cccaggcttg agtgcagtgg tgcaattttg gctcattgca acctccacct ctcccgggct 5101 caaggaagtc tcctgctgca gcctcccgag tagctgggac gacaggcacg caccaccacc 5161 cccagctaat ttttgtattt ttagtagaga cagggtttca ccatattggt caggctgatc 5221 tcaaactcct gacctcaggt gatccaccca ccttcagcct cccaaagtgc tgggattaca 5281 ggcatgagct actgcgccct acctataatt gttttttaaa ttataaaaac aatatgtgat 5341 cactcgaggg aaaaatgagc caaaacaaaa aaaggaaaca tttaattaaa tcaccctgaa 5401 cttcagtacc aaagtagcca ccgctaatat ttcggcttat atattttccc actctttatt 5461 acatccatgc acaaaatatg tattcacaaa tacagaaaat atgtttgtgc aagtatggga 5521 ttatataagc acatcagtat catgtcaata catataaaac atttttaatg actccaaaat 5581 gttacagaag gatgcatcaa ttttaaaatt agtcctttgt tgatagacat gtggtatttc 5641 catttttttt ttccccctga gatagaatct cactctgttg cccaggctgt agtgcagtgg 5701 cacgatctcg gctcactgca acctctgcct cccaggttta agtgattctc atgcctcagc 5761 ctctggagta gctgggacta caggcgcaca ccaccacatc caactaattt ttgtgttttt 5821 ggtataaacg gggtttcgcc acgttggcca ggctgatctt gaactcctga cctcaagtga 5881 tccacctgcc tcagcctccc aaagtgctgg gattataggc atgagccacc atgcctggcc 5941 aaagttttgt aatatgacag aacactgcaa tgaactggaa gataggactt taaatttgat 6001 ccttttgctt gctttgtagt tactaaataa ccttgataga tgatgtttta gtaaatctgt 6061 atttgacttt cttatggttt tattagcttg gcaagtgttg aagaaaacag ttcattctga 6121 aagaacactt ctgaaaatgt actaaaagtt tagctaggga ggggcacccc acaattgaaa 6181 cctttatttt tcagtctgtg ctcccaaaga ttgggagcaa aaaaggacat ttggggtgag 6241 gggatcatag agaagagagg gtgaaaggaa gagaactaat gcaagtaaag tgcttgtttt 6301 acacttggtt tgatggggag gttgggccac aagaggagta tacttaaaat aaaaattaaa 6361 ttaaaagttt taggccaagc gtggtggctc acgcctgtaa tcccagcact ttggaagtca 6421 aggcgggtgg atcacaaggt caggagatca agaccatcct ggctaacatg gtgaaaccct 6481 gtctctacta aaaatacaaa aaattagccg ggcatggtgg cgggcgcctg tagtcccagc 6541 tgcttgggag gctgaggcag gagaatggcg tgaacccggg aggtcgagct tgcagtgagc 6601 cgagatcgtg cctctgcact ccagccgggg caacagagtg agactccgtc tcaaaaaaaa 6661 aaaagtttta cacgcagatt ttcccaaaat tgtgtaaatc ggaagggtct aaaaaaaagt 6721 gaaaatctct cattctttct ggtctccaat ctcagcacaa cttctcgggt tttgtttgtt 6781 tggttggttg gttttttttt tttttttttg agatggagtc tcgctgtgtc gcccaggctg 6841 gagggctgga gtgcagtgat gtgatctcag ctcactgcaa cctgcgcttt ccaggttgaa 6901 gtgattctcc tgcctcagcc tctcaagtag atgggattac agatgcgcgc caacacctcc 6961 ggctaatttt tgcattttta gtaaagccag aattttgcca tgttggccag gctggtcttg 7021 aattcctgac ctcaagtgat ccgcccgcct tggcctccca aagtgctggg attataggtg 7081 tgagtcacta ttcctggcca tcagctcaac ttctctatgc acaaatgatt tataggaata 7141 gaaggagcat accgtactgt acatactgtg ctatgattta tttatctttt tttacctaat 7201 cgattcatag tcagtttata gaaatctgta caaacttttt tttttttttt ttgagacgga 7261 gtcttgccgt gtcgcccagg ctggagtgaa ggggcgctat ctcagctcgc tgtaagctct 7321 gcctcccggg ttcatgccat tctcctgcca cagcctccca agcagctggg actacagacg 7381 cccgccacca tgcccggcta attttttgta tttttagtag agacagggtt taaccgtgtt 7441 agccaggatg gtctcggtct cctgacctcg tgacccacct gcctcggcct cccaaagtgc 7501 tgggattaca ggcgtgagcc actgcgccga acctggtaca aacttttata ggggggtaat 7561 tgaactagtc ctccccacca cacccccccc cccttttttt tttaaagaga ctgggtctgg 7621 ctgtcaccca agctggagtg cagtggcagg atcatagctc acccccagct aatttttttt 7681 ttagacggag ctcccaagta gctggggcta tggctaggtt gccactatgc ctggcctgaa 7741 ctactcccct cttcccgccc atccccgaac cccagatgaa gtcttgctct gtcacccagg 7801 ctggagtgca gtggtgtgat ctcagctcac tgcaacctcc gcctcccagg ttcaagcctc 7861 ccaggttcag cctcccaagt agctgggatt acaggtgccc gccaccacac ccagctaatt 7921 tttgtatttt tagtagagac ggggtttcac catgttggcc acgctgatct caaactcctg 7981 atctcatgat ccgcccgcct tagcctccca aagtgctggg tttacaggcg tgagccaccc 8041 tgccagggcc tgaactactc ccctttttga tagatgttga aattaacatt gttttaccat 8101 gctaaacaat gttccagtga atattctagt acataaaata gctttgtgca ctttagctgg 8161 taggtgcagg gcaaattcct agaagtaaat tgctaggtca tatggcaaat acatttaaaa 8221 ttttgatatg ttttgccaaa ttacccacca aaaatattat atcaatttat attcctttga 8281 gatacaaaat tcaaataata tagagaggtg taaaataaaa agaaaagttc tcttgtcccc 8341 agctattcta ctccacagag ccagccactt tttattgttt ggtggatatc cttctagact 8401 tcagattttg caaattgtac attataattt tttttttttt ttttttttga gacagagtct 8461 cgctctgttg ccaggctgaa gtgcagtggc atgatctcgg ctcactgcaa cctctgcctt 8521 ctgggttcaa gcgattctcc tgcctcagcc tctggagtag ctgggactac aggcgcgtgc 8581 actacactta gctaattttt gtatttttta gtagagattg ggtttcacca tgttggtcag 8641 gatggtctcg atctcttgat ctcaggatcc acccgcctcg gcctcccaaa gtgctgggat 8701 tacaggtgtg agccaccatg cctggccagt ttcttttttc aattgactgt atattgtggc 8761 tgtctttcca tttcaatatt attggctact atattgtcta cccttagtag tagggactac 8821 gtcagggaca tgctaagtta ggaatagaaa taaggagctg tttgtctgta actgagtggg 8881 gggatgctgc cttgagcatc tgtgagtgtg tattttcaca cacttgggca ataattgttt 8941 attacagccc tagaaatggg aatgtaattg tagccaggca ctttatttgt gtttaaactt 9001 catttgtgca tttagtctct cctcaactct gtgaaataga aatgatttta cctggttgac 9061 aattgggagc tgggatagca tcggttctct agacaagctc tgtgagtttt ggtgagtggt 9121 aaggaccctg tacagagtca gagcaaatgc actgggcaag ggcttcaggg accttcgagt 9181 agcatcttga catttaccag tgttatagaa cagttaatat caacaatagt tttgatggag 9241 accattaaag gttatgtgtt gaaatattct aagaaaaagt tcctttttaa aaaaaaattg 9301 ttatattgcc attccttgct ccttttttgg tctttatttt agcattctta tttaaaacag 9361 attttgagca ctctttatgt gagctttcct gacttggtac atgcttattt ttatggagaa 9421 ttttaatctt atagaaatat actattatag tgaattaagt gtatccacca ctcaacttca 9481 ataattatta actgttggct aatcttgttt catctattcc caaactcacc tcccactcct 9541 cttccctgtt atttcttttc tgtttttttc cctttcctat gatgccaagc ctgtgttttt 9601 tttttaacag ctttaccaag aattccatat cagataattt gcacaccata caattcaccc 9661 ctttaaactg tacaatttag tggcttttag gatgttcata gaattattca accattacca 9721 caattttaga acatttttat taccctggaa gaaacagttt agctgtcatt caccaatctt 9781 ctggtcttag cccttggcaa acactaatct actttctatt tatggatttg cctattgtag 9841 acatttgata gaaatgggat aatgtgttgt cctctgtgac tggcttcttt cacttagcat 9901 aatcttttgg agattcatcc atgtatctat gtatcagtac tttttttttt ttttgagaca 9961 gagtcttgct ctgtcaccca ggctggagtg cagtggtgca atctctgcaa cctttgcctc 10021 tagtttcaag tgattctcct gcctcagcct cctgagtagt tgggactgtg ggcccacacc 10081 accacctctg gctaattttt gtatttttag tagagactgg gtttcaccat gttggccagg 10141 ctggtcttga gctcctgacc tcaggtgatc tgcctgcctc agcctcccaa gtacttgatt 10201 tttgaaaaca gccaaataat attccattgt atggatatac tgctttttat ttcttttcaa 10261 ttgttgatgg acatttggat tgtttccact tttttttcct ttttttgaga cagggtcctg 10321 ctctgttgcc caggctggag tgcagtggtg taatctctga cctcctaggt tcaagctgtc 10381 ctcctgcctc agccttccta gtagtgggac tacaagtgtg caccactatg cctggctaat 10441 tttgtaaaat gtttgtagag atggggttct gctctgttgc ccaggcttgt ctcaaattcc 10501 tggcctcaag cacttctccc atctcatcct cccaaagtga taggattaca ggtgagcacc 10561 actgtgccca gcccacttgt tgactgtggg ctgggcacag tgctatatta taatgctgct 10621 atggctgggc gtggtggctc acgccctgta atcccagcac tttgggaggc cgaggtgggc 10681 ggatcacaag gtcaggagat cgagaccatc ctggctaaca ctgtgaaacc ccatctctac 10741 taaaaataca aaaaaaaaaa aaaaaaaaaa aaatnnnnnn nnnnnnnnnn nnnnnnnnnn 10801 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 10861 nnnnnnnnnn nnnntttttt tttttttttt tttgagacgg agtcatgctc tgttgcccag 10921 agtgcaatgg cacagtctag gctcactgca acctccgcct cccaagttca aatgattctc 10981 ctgtctcagc ttcccgagta gctgggacta taggcgtgtg ccaccacacc cagctaattt 11041 ttgtattttt aatagagatg gggtttcacc atgttagcca ggtgggctca aaaccccgac 11101 ctcgtgatct gcctgcctca gcctcccaaa ttgctgggat tacaggcgtg agccatgcgt 11161 ccagccatat aggaactctt taaccatttg aggaactgcc agataatttc ccacaataac 11221 tgtacctttt attttatttt attttattta ttttaaatag acatggtttc actctgtcgc 11281 ccaggctgga gtgcaatggc gtgatcttgg ctcattgcaa cctgtgcctc ccggttcaaa 11341 tgattctcct gtctcaccct cccaagttgc tgggattata ggtgtatgcc accacacctg 11401 actaattttt gtatttttag tagagatggg gtttcaccat gttggccagg ctggtctcga 11461 actcctgacc tcaggtgatc cacccacctc ggcctccaat agtgctggga ttagaggtgt 11521 gagctactct gcccagccgt gcaccagttc gtattcctac cagcagtgtc tgagagtttc 11581 aattcctgtg gttgtgaaat aaatctcaga tataatttca tcctaaagta ttttagaatg 11641 tattaataaa gtatgaggga tttctttttc aaatataaac ataatgccat tatagtatct 11701 actaacatta atttttaata taatcaaata ttcagtcagt attcaaattt ctttcttttt 11761 tttttttttt taatatagag acaggggcct cactctgtca cccagagtgg agtgcagtgg 11821 cacaatctca ctgaatcatt gaactcctgg tctcaagtga tcttcctgtt tcaactttcc 11881 aagtatccag gactacaggt gtgcgccacc atgcctggct aatttttttt ttttttaatt 11941 ttttgtagag acacggtctt gctatgttgg ccaggctggt ctcaaactct tggcctcgag 12001 caatccttcc acgtcagcct cgcaaagcac tgggattata ggcatgaaca accgtgcctg 12061 gctttgtgtt caaatttcta attgtcttat aaatgttatt ttaggccggg tgcagtggct 12121 catgcctgta attccagcac tttgggaggc tcaggtgggc agatcacttg agatcaggag 12181 ttcgagacca gcttgaccaa catggtgaaa ccccatctct actaaaaata caaaaattag 12241 ctggatgtag tggtgtgcac ctgtaatccc agctccttgg gaagctgagg caggagaatt 12301 gcttgaacct gggagacgga ggttgcagtg aaccaagatc gcaccactgc actccagcct 12361 gggcgacaga gtaagactcc atctcaaaaa aaaaaacaag ttatttttat ggtttgtttg 12421 aatcaggatt gaaacaaggt acacacatta tatgactgat atgtctttta aatcttctac 12481 tctataaatt tcacctccac accttttttt tacctttgtt cttcttcttc ttcttttttt 12541 tttttgaaga gatggcattg tgctatgttg ccctggctgg tcttgaactc ctggtctcaa 12601 tcaatcctcc tgctttggcc tctcaaagtg ctgggtattg aaggcatgag gcactgtgcc 12661 tggccctctt tcttattttt tgccttataa tttatatttt gtaaaaaaca ggtcctttat 12721 cctgtagcag ttcccagagt ctcaatttta ctgactacat ttgtggtgtt gtttaacact 12781 ttgccccctt catttccatt aatttggtgt tggataattt ccacaataac tgcaccagtt 12841 gctcagtcta taacactaat caagcactga atccaacacc aaattaattt ccagtatgtt 12901 actttctaat tgttacatac attgtcattc taagttaagt ggcctgtgaa atcagtgtta 12961 aagaataata actggctttt tataataatg gaatagaata caatagaaag tatcagtgca 13021 ccctatgtaa taagaataat tattattttg tgaaacgttt ttccaccatg gatatgtgta 13081 ttgggaactg ggttagtatg tggaatatgg ttcttagggg ttatggtcaa atatttgaag 13141 aacactgtaa tatgtaggaa ttttttttaa atttaaaaac aacatatgtt ctttttgaag 13201 aattatataa aaaaaataga accactagaa ataggactat cctaggcata ttagtttctt 13261 gtggctacca tagcaaattg ccataaactg atgatgtaaa acaacacatt tattctgtca 13321 gttctggaga ccagaagtct gaaatcaagg aattggggcc acaagccctc caaaagctct 13381 aagggagagt ccattccttg ccttttccag cttgcagtgg ctgctggcat ttcttggcat 13441 tcttggcctg ttccttgatg tgactccaat ctctgcctcc attctcatgt cactcactcc 13501 tctggcttct ccttttctgc gtgttgcaga tctctttctg cttttctctc tgttttgttg 13561 tttgatacag actttaactc tgtcgcccag gctggagtgc agtggcgcaa tcttggctca 13621 ctgcaacctc cgcctcccag gttcaagcaa ttctcctgcc tcagcctccc aagtagctag 13681 aactacaggc gcctgccacc acgcccggct aatttttgta tttttagtag agacagggtt 13741 tcactatgtt ggccaggctt gtcttgaact tctgacctcg tgatccaccc acctcagcct 13801 cccaaagtgc tgggattaca ggcgtgagac accacgccag gcctctgcct ttatcttaga 13861 aacgacactt gtcattggat ttagggcccg cctagataac ccagggagat cttcttatct 13921 taggatcctt aattctatct gcaaagacgt ttttgctaaa taatgttcac agagtctggc 13981 gattaggaca tagacttctc ttttgggggc accacctttc aacccactac actaagtgaa 14041 aagtgaaata ttgatctcta catcccccaa cactccaccc aggctagcat cccaaatagg 14101 gaagcattaa gatgtgaaaa attctgcgga acattagtgt aaagcttcta gtggaaaaat 14161 gatgaccaag cataacatta tgagataaga gcatgagtag gtttaatatc cccctggtat 14221 acggcagtgc aagtattgcc ctgtcttctc tgcttggtga ggcctacttt tccccagaat 14281 tagagtaaaa ttattcagta tccttatatt gtccttactt actcctgcag gttcatgaat 14341 acttaggggc agaatgtagg gaggacatgc cattcatttc tttgtggttt ttaggtcaac 14401 ttcataatat aagagaggga taataagtta gcttgtcatg ctacatgctt gaaagtctgt 14461 catcagtaca gccacctatc caggccagac ggtttccctg ccagttggcc tccatgggac 14521 attctccagg aaaccagcac atgagcaggg aaaatccctg ccattgttga ggctatcatt 14581 gtgggtgaaa agggaatgtc ccttgtggtc ctggaatctc cctgtggcaa gctctgaata 14641 gggtatgatg aattgaatag gccaggaagg atcctggctc agggctagag tgggatagaa 14701 ggccattatg aagtgagaaa ttagaaaact ggtgtcagga tggggatcgc tattttacac 14761 acttgagaat ttagaaagga attactgcac attcctaaac tgattttttt tttttttttt 14821 tgactgaggc tcgctctgtc acccaggctg aagtgcagtg gcatgatctt ggatcactgc 14881 aacctccact tccggggttc aagcgattct tctgcctcag cctcccaagt agctgggatt 14941 acaggcgcct gcgcctggct aatttttgta tttttaacag agtcagggtt tcgccatgtt 15001 agccaggctg gtctgaaact cctgacctca ggtgatccac ctgccttagc ctcccaaagt 15061 gctgagatta cacgcatgag ccaccatgcc cagccaaacc aaattttact aattgataaa 15121 tcaaaggact gttgttggtc atgtgataag aatagctaga gctgggcgtg atgtctcaca 15181 cctgtaattc cagcactttg ggaggccaag atgggaggat cacttgaagc caggagttcg 15241 agaccagctt agtcaacata gcaagacccc atctctaaaa aaaaaaaaaa taataagtaa 15301 aataaaaaga atagctgggg actaatgagt gtggacagtt tgtaaaaata aattgaaata 15361 ttgttagtct tctttatatt cctagaaatc gatgctccac atgcatccca caactcctta 15421 caactccccg atacaaaaat actcactgta agaaaaaaac ccataaaacc aaactaaacc 15481 agacaataga aatcccaata atctcattac acaaagaaaa gcccctataa gcattttgtg 15541 taatcctcta atagtacatt tctgttttca tctaaagtac tttcatttga ggctgggctc 15601 agtggctcac acttgtatct caccactttg ggaggctgag gcaggagaat cttaaggcca 15661 ggagtttgag aacagcctgg gcaacatagt gagatcctat ctctacaaaa agtaaaaaat 15721 tagctgggtg tgatggtgtg tgcctgtggc ctggctgttt aggaggattg cttgagtcca 15781 aaagtttgag gctgcggtgc attatgatcg ctccactacg ctccagcctg ggtgacagcg 15841 agaccctgtc tcataaatta aaaaatgaat aaatgaatgt actttcattt gaacaaacca 15901 gtgttactgc tgaaacattt atttctgtaa tgacccttgt cttcctttct tgtacaggaa 15961 ccaatagatc ctctaaagga agaagcctta ttggtaaggt tgatggcaca tcccacgtca 16021 ctggaaaagg agttacagtt gaaacagtct tttctgtgga tgagttttct gcatctgtcc 16081 tcactggaaa actgaccact gtcttccttc caattgtcta cacaattgtg tttgtggtgg 16141 gtttgccaag taacggcatg gccctgtggg tctttctttt ccgaactaag aagaagcacc 16201 ctgctgtgat ttacatggcc aatctggcct tggctgacct cctctctgtc atctggttcc 16261 ccttgaagat tgcctatcac atacatggca acaactggat ttatggggaa gctctttgta 16321 atgtgcttat tggctttttc tatggcaaca tgtactgttc cattctcttc atgacctgcc 16381 tcagtgtgca gaggtattgg gtcatcgtga accccatggg gcactccagg aagaaggcaa 16441 acattgccat tggcatctcc ctggcaatat ggctgctgat tctgctggtc accatccctt 16501 tgtatgtcgt gaagcagacc atcttcattc ctgccctgaa catcacgacc tgtcatgatg 16561 ttttgcctga gcagctcttg gtgggagaca tgttcaatta cttcctctct ctggccattg 16621 gggtctttct gttcccagcc ttcctcacag cctctgccta tgtgctgatg atcagaatgc 16681 tgcgatcttc tgccatggat gaaaactcag agaagaaaag gaagagggcc atcaaactca 16741 ttgtcactgt cctggccatg tacctgatct gcttcactcc tagtaacctt ctgcttgtgg 16801 tgcattattt tctgattaag agccagggcc agagccatgt ctatgccctg tacattgtag 16861 ccctctgcct ctctaccctt aacagctgca tcgacccctt tgtctattac tttgtttcac 16921 atgatttcag ggatcatgca aagaacgctc tcctttgccg aagtgtccgc actgtaaagc 16981 agatgcaagt atccctcacc tcaaagaaac actccaggaa atccagctct tactcttcaa 17041 gttcaaccac tgttaagacc tcctattgag ttttccaggt cctcagatgg gaattgcaca 17101 gtaggatgtg gaacctgttt aatgttatga ggacgtgtct gttatttcct aatcaaaaag 17161 gtctcaccac ataccatgtg gatgcagcac ctctcaggat tgctaggagc tcccctgttt 17221 gcatgagaaa agtagtcccc caaattaaca tcagtatcag tgtctgtttc agaatctctc 17281 tactcagatg accccagaaa ctgaaccaac agaagcagac ttttcagaag atggtgaaga 17341 cagaaaccca gtaacttgca aaaagtagac ttggtgtgaa gactcacttc tcagctgaaa 17401 ttatatatat acacatatat atatatattt tacatctggg atcatgatag acttgttagg 17461 gcttcaaggc cctcagagat gatcagtcca actgaacgac cttacaaatg aggaaaccaa 17521 gataaatgag ctgccagaat caggtttcca atcaacagca gtgagttggg attggacagt 17581 agaatttcaa tgtccagtga gtgaggttct tgtaccactt catcaaaatc atggatcttg 17641 gctgggtgcg gtgcctcatg cctgtaatcc tagcactttg gggaggctga ggcaggcaat 17701 cacttgaggt caggagttcg agaccagcct ggccatcatg gcgaaacctc atctctacta 17761 aaaatacaaa agttaaccag gtgtgtggtg cacgtttgta atcccagtta ctcaggaggc 17821 tgaggcacaa gaattgagta tcactttaac tcaggaggca gaggttgcag tgagccgaga 17881 ttgcaccact gcactccagc ttgggtgata aaataaaata aaatagtcgt gaatcttgtt 17941 caaaatgcag attcctcaga ttcaataatg agagctcaga ctgggaacag ggcccaggaa 18001 tctgtgtggt acaaacctgc atggtgttta tgcacacaga gatttgagaa ccattgttct 18061 gaatgctgct tccatttgac aaagtgccgt gataattttt gaaaagagaa gcaaacaatg 18121 gtgtctcttt tatgttcagc ttataatgaa atctgtttgt tgacttatta ggactttgaa 18181 ttatttcttt attaaccctc tgagtttttg tatgtattat tattaaagaa aaatgcaatc 18241 aggattttaa acatgtaaat acaaattttg tataactttt gatgacttca gtgaaatttt 18301 caggtagtct gagtaataga ttgttttgcc acttagaata gcatttgcca c //